Abstract: In alternative embodiments, provided are solutions for peritoneal dialysis for use for maintaining or restoring the removal of small solutes and fluids in subjects with end-stage renal disease and/or congestive heart failure. In alternative embodiments, such solutions comprise carnitine, xylitol and at least one of glucose, glycerol and polydextrin.

Abstract: In alternative embodiments, provided are solutions for peritoneal dialysis for use for maintaining or restoring the removal of small solutes and fluids in subjects with end-stage renal disease and/or congestive heart failure. In alternative embodiments, such solutions comprise carnitine, xylitol and at least one of glucose, glycerol and polydextrin.

Abstract: In alternative embodiments, provided are solutions for peritoneal dialysis for use for maintaining or restoring the removal of small solutes and fluids in subjects with end-stage renal disease and/or congestive heart failure. In alternative embodiments, such solutions comprise carnitine, xylitol and at least one of glucose, glycerol and polydextrin.

Abstract: In alternative embodiments, provided are solutions for peritoneal dialysis for use for maintaining or restoring the removal of small solutes and fluids in subjects with end-stage renal disease and/or congestive heart failure. In alternative embodiments, such solutions comprise carnitine, xylitol and at least one of glucose, glycerol and polydextrin.

Abstract: A composition comprising citrate and carnitine which activates the production of the protein Klotho by renal tubule cells protecting them, thus reducing the oxidative stress conditions thereof, which can be used for the conservation, perfusion and reperfusion of organs for organ transplants is disclosed. Furthermore, the composition in the liquid and dietary/nutraceutical formulation can be used for reducing the nephrotoxicity induced by iodinated contrast means, antibiotics, NSAIDs 10 or agents that induce oxidative stress.

Abstract: In alternative embodiments, provided are solutions for peritoneal dialysis for use for maintaining or restoring the removal of small solutes and fluids in subjects with end-stage renal disease and/or congestive heart failure. In alternative embodiments, such solutions comprise carnitine, xylitol and at least one of glucose, glycerol and polydextrin.

Abstract: A connecting device (1) for connecting therebetween the respective ends of two ducts prevents that the inside portion of the ducts comes in contact with the atmosphere and with polluting agents before the complete connection thereof by keeping the connection procedure simple to be performed and it comprises two connecting members (2, 4) provided with tubular ends (12, 27) and respective concentric and coaxial tubular casings (17, 32), which penetrate by breaking in sequence respective breakable barriers (20, 40) arranged inside said connection members (2, 4), wherein at lest one of said first and second connecting member (2, 4) comprises a sliding guide comprising at least a groove formed on a surface of an outer cylindrical casing (6) of a connecting member (2), apt to cooperate with a corresponding rib or with one or more teeth (9) implemented at an inner surface of an outer cylindrical casing (8) of the other connecting member (4).

Abstract: A connection device, to connect two ends of respective ducts to another flexible duct in the field of the peritoneal dialysis including a closed container containing two nozzle-like terminal ends of a Y-shaped branch of a flexible duct; a removable connection member configured to be engaged/disengaged on the closed container, containing the ending portions of the respective ducts shaped to couple/uncouple with the nozzle-like terminal ends, a distal end of the container and the connecting member are shaped to couple according to a guiding scheme with prismatic joint; a closure with mobile walls on the closed container is actuated in opening and closing by the contact of a projecting septum of the connection member upon the connection/disconnection between the closed container and the connection member; and a closure with removable tear film arranged at the ending portions of the ducts to close the respective sections opened inside the connection member.

Abstract: A coupling device for connecting two ends of respective tubular members, allow the opening and the closing of a first tubular member and the simultaneous engagement of the two tubular members, as to prevent pollution, includes: a first case housing a first end of a respective first tubular member, comprising closing means of said first end; a second case, wherein a flexible terminal section of a respective second tubular member is received, comprising means for driving a second end of said second tubular member from a retracted position to a engagement position into said first end and vice versa; and means for reversibly connecting said first and second cases at a respective coupling port thereof, defining a single sealed environment; wherein the engagement and the disengagement of said second end and the automatic mechanical activation and deactivation of said closing means for opening and closing said first end.

Abstract: A coupling device (1) for the connection of two ends (3, 9) of respective tubular members (2, 5), allowing the contact of the flowing fluid only with elements inside a closed container, circumstances and an inherently easy connection operation, thus it can be carried out, comprising: a closed container (10) housing said ends (3, 9) of respective tubular members (2, 5), one of said tubular members having a flexible terminal section (8) thereof inside said closed container; a mobile connection member (15), coupled at the end of said flexible terminal section (8), having a nozzle (16) apt to be inserted within a receiving end of the other tubular member,—and a cam device, located inside said closed container (10) and apt to be actuated from the outside of said closed container, apt to cooperate with said mobile connection member (15), the cam device causing the insertion and the ejection of said nozzle in and from said receiving end, and the corresponding connection and the disconnection of the two ends.

Abstract: The use of L-carnitine and its alkanoyl derivatives, optionally in the form of a pharmaceutically acceptable salt, as osmotic agents in the preparation of solutions for medical use, particularly for peritoneal dialysis, is described.

Abstract: Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the materials so treated exhibit extended circulation half life upon transfusion to a patient. Improvements in membrane maintenance achieved by this method permit irradiation of sealed containers of blood products so as to substantially sterilize and destroy leukocytes in the same.

Abstract: A coupling device (1) for the connection of two ends (3, 9) of respective tubular members (2, 5), allowing the contact of the flowing fluid only with elements inside a closed container, circumstances and an inherently easy connection operation, thus it can be carried out, comprising: a closed container (10) housing said ends (3, 9) of respective tubular members (2, 5), one of said tubular members having a flexible terminal section (8) thereof inside said closed container; a mobile connection member (15), coupled at the end of said flexible terminal section (8), having a nozzle (16) apt to be inserted within a receiving end of the other tubular member,—and a cam device, located inside said closed container (10) and apt to be actuated from the outside of said closed container, apt to cooperate with said mobile connection member (15), the cam device causing the insertion and the ejection of said nozzle in and from said receiving end, and the corresponding connection and the disconnection of the two ends.

Abstract: A coupling device for connecting two ends of respective tubular members, allow the opening and the closing of a first tubular member and the simultaneous engagement of the two tubular members, as to prevent pollution, includes: a first case housing a first end of a respective first tubular member, comprising closing means of said first end; a second case, wherein a flexible terminal section of a respective second tubular member is received, comprising means for driving a second end of said second tubular member from a retracted position to a engagement position into said first end and vice versa; and means for reversibly connecting said first and second cases at a respective coupling port thereof, defining a single sealed environment; wherein the engagement and the disengagement of said second end and the automatic mechanical activation and deactivation of said closing means for opening and closing said first end.

Abstract: Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the materials so treated exhibit extended circulation half life upon transfusion to a patient. Improvements in membrane maintenance achieved by this method permit irradiation of sealed containers of blood products so as to substantially sterilize and destroy leukocytes in the same.

Abstract: The use of fibrates, particularly clofibrate, is described for the preparation of a medicament useful in the treatment of congestive heart failure.

Abstract: The protective effect on peritoneum of L-carnitine and its lower alkanoyl derivatives, both in the form of inner or pharmaceutically acceptable salts is disclosed. Concentrations of carnitine from about 0.02 to 0.5% w/v are suitable for preparing a solution for peritoneal dialysis having higher biocompatibility and protecting peritoneum from toxic effects of continuous use of solutions for peritoneal dialysis, in particular ones containing glucose as osmotic agent. A particularly preferred embodiment is a solution for peritoneal dialysis containing carnitine, glucose and xylitol.

Abstract: Formula (I) compounds are described in which the substituents have the meanings described in the text, and which are useful for the treatment of diseases responding to PPAR?activation, such as heart failure, the hyperlipaemias and atherosclerosis.

Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine palmitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.

Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine polymitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.