Patents by Inventor Arend Heise

Arend Heise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4675329
    Type: Grant
    Filed: June 27, 1985
    Date of Patent: June 23, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Andreas Knorr, Kurt Stoepel, Arend Heise
  • Patent number: 4360520
    Abstract: The invention includes new 1,4-dihydropyridazine compounds, compositions containing said 1,4-dihydropyridazine compounds and methods for the use of said compounds and compositions. Also included in the invention are methods for preparing the new 1,4-dihydropyridazine compounds.
    Type: Grant
    Filed: September 11, 1978
    Date of Patent: November 23, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Meyer, Gerhard Franckowiak, Friedrich Bossert, Arend Heise, Stanislav Kazda, Kurt Stoepel, Robertson Towart, Egbert Wehinger
  • Patent number: 4348395
    Abstract: The invention includes, as novel compounds, 1,4-dihydropyridazines and methods for their preparation. Also included are compositions containing said compounds and methods for the use of said compounds and compositions. The compounds of the invention are active as circulation-influencing and spasmolytically active agents.
    Type: Grant
    Filed: October 4, 1978
    Date of Patent: September 7, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Franckowiak, Horst Meyer, Friedrich Bossert, Arend Heise, Stanislav Kazda, Kurt Stoepel, Robertson Towart, Egbert Wehinger
  • Patent number: 4280998
    Abstract: The invention relates to 1,4-dihydro-pyridazine-3-carboxylic acid derivatives and compositions containing said derivatives. Also included in the invention are methods for the manufacture and use of said compounds and compositions. The derivatives of the invention influence the circulation and have a spasmolytic and anti-inflammatory action.
    Type: Grant
    Filed: July 18, 1979
    Date of Patent: July 28, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Franckowiak, Friedrich Bossert, Arend Heise, Robertson Towart
  • Patent number: 4256749
    Abstract: The invention relates to fluorine-containing 1,4-dihydropyridine compounds and method for their preparation. Also included are compositions containing said fluorine-containing 1,4-dihydropyridine compounds and the use of said compounds and compositions as agents for influencing circulation.
    Type: Grant
    Filed: September 10, 1979
    Date of Patent: March 17, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Harald Horstmann, Friedrich Bossert, Arend Heise, Stanislav Kazda
  • Patent number: 4248873
    Abstract: The invention includes novel nitro-substituted 1,4-dihydropyridines useful because of their influence on the circulation. Also included in the invention are methods for the preparation of said novel nitro-substituted 1,4-dihydropyridines, compositions containing them and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: November 6, 1978
    Date of Patent: February 3, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Friedrich Bossert, Gerhard Franckowiak, Arend Heise, Stanislav Kazda, Horst Meyer, Kurt Stoepel, Robertson Towart, Egbert Wehinger
  • Patent number: 4188395
    Abstract: The present invention provides 1,4-dihydropyridine derivatives of the formula in which ##STR1## R represents hydrogen, alkyl, alkenyl, alkoxyalkyl, aryl or aralkyl, the alkyl and aryl groups being optionally substituted,A represents a straight-chain or branched alkylene radical,R.sup.1 represents (a) an optionally substituted alkylthio group or (b) a group of the formula O--CO-alkyl, O--CO-aryl or O--CO-aralkyl, the alkyl and aryl groups being optionally substituted or (c) a phthalimido radical which is optionally substituted in the benzene ring, Y and Z are identical or different and each represents a group of the formula COOR.sup.2 or COR.sup.2,whereinR.sup.2 represents alkyl, alkenyl, alkinyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl or aralkyl, the alkyl and aryl radicals being optionally substituted, orY and Z are identical or different and each represents a cyano radical or a radical of the formula S(O).sub.n --R.sup.3,whereinR.sup.
    Type: Grant
    Filed: December 1, 1977
    Date of Patent: February 12, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Friedrich Bossert, Egbert Wehinger, Horst Meyer, Arend Heise, Stanislav Kazda, Kurt Stoepel, Robertson Towart, Wulf Vater, Klaus Schlossmann
  • Patent number: 4187306
    Abstract: The invention covers compounds of the formula ##STR1## in which R.sup.1 and R.sup.5 each represents 0, 1, 2, 3 or 4 of the following substituents: alkyl, hydroxyl, acyloxy, alkoxy, nitro, amino, alkylamino, dialkylamino, acylamino, acylalkylamino, alkoxycarbonylamino, halogen, trifluoromethyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, aminosulphonyl, alkylaminosulphonyl, dialkylaminoamino, R.sup.2 is hydrogen, optionally substituted alkyl, aralkyl or aryl or heterocyclo-alkyl, acyl or alkoxycarbonyl, and R.sup.3 and R.sup.4 are each hydrogen, or optionally substituted alkyl, aralkyl, aryl or hetero-aryl, are useful as medicaments which have an action on the central nervous system, in particular as, for example, tranquilizers and/or antiamnesics. Also included in the invention are methods for preparing said compounds, compositions containing them and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: July 6, 1978
    Date of Patent: February 5, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl H. Mayer, Helmut Heitzer, Friedrich Hoffmeister, Arend Heise, Stanislav Kazda
  • Patent number: 4179500
    Abstract: The invention concerns the provision of novel 1,4-dihydropyridine-sugar derivatives and processes for their preparation. The invention also concerns pharmaceutical compositions containing the compounds of the invention and methods for their use. The products of the invention, such as 2-[1,4-dihydro-5-(2-propyl)-oxycarbonyl-2,6-dimethyl-4-m-nitrophenyl-3- pyridylcarbonyloxy]-ethyl .beta.-D-glucopyranoside, are effective for the treatment of circulatory disorders and can be used as antihypertensive agents, vasodilators or coronary therapeutic agents.
    Type: Grant
    Filed: August 26, 1977
    Date of Patent: December 18, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bodo Junge, Friedrich Bossert, Horst Meyer, Egbert Wehinger, Wulf Vater, Arend Heise, Stanislav Kazda, Kurt Stoepel
  • Patent number: 4177278
    Abstract: The invention includes the provision of 2-alkyleneaminodihydropyridines and salts thereof and are useful, inter alia, as coronary dilators and antihypertensive agents. Also included in the invention are pharmaceutical compositions containing said 2-alkyleneaminodihydropyridines and methods of treatment involving the use of said compounds or compositions.
    Type: Grant
    Filed: March 15, 1978
    Date of Patent: December 4, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Friedrich Bossert, Egbert Wehinger, Arend Heise, Stanislav Kazda, Kurt Stoepel, Robertson Towart, Wulf Vater, Klaus Schlossmann
  • Patent number: 4166855
    Abstract: The invention provides a novel compound, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid isopropyl 2-propoxyethyl ester and processes for its preparation. In addition, the invention includes the provision of compositions containing the compound of the invention and methods for treating warm-blooded animals for peripheral perfusion disturbances.
    Type: Grant
    Filed: October 6, 1977
    Date of Patent: September 4, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Friedrich Bossert, Horst Meyer, Arend Heise, Stanislav Kazda, Kurt Stoepel, Wulf Vater
  • Patent number: 4162321
    Abstract: The invention relates to new dihydropyridines which are substituted by an amino group in at least one of the 2- and 6-positions, by a sulphur-containing substituent in the 3-position, by a cyclic substituent in the 4-position and by a carbonyl substituent in the 5-position. The new dihydropyridines are particularly useful as agents which influence the circulatory system. Also included in the invention are procedures for preparation of the new dehydropyridines, compositions containing them and methods for their use.
    Type: Grant
    Filed: August 26, 1977
    Date of Patent: July 24, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Friedrich Bossert, Horst Meyer, Gerhard Franckowiak, Wulf Vater, Arend Heise, Stanislav Kazda, Kurt Stoepel
  • Patent number: 4154839
    Abstract: The isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate demonstrates the unique ability of increasing myocardial perfusion upon oral or intravenous administration. Methods of preparing the compound, its use in coronary conditions and pharmaceutical compositions for effecting that use are disclosed.
    Type: Grant
    Filed: May 8, 1978
    Date of Patent: May 15, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Friedrich Bossert, Arend Heise, Stanislav Kazda, Kurt Stoepel, Wulf Vater
  • Patent number: 4146627
    Abstract: The circulation provides new aminoalkylidene-amino-1,4-dihydropyridines which influence the circulatory system and are useful, for instance, as antihypertensive agents. Also included in the invention are methods for the preparation of said dihydropyridines, compositions containing them and methods for their use.
    Type: Grant
    Filed: August 26, 1977
    Date of Patent: March 27, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Friedrich Bossert, Horst Meyer, Wulf Vater, Arend Heise, Stanislav Kaada, Kurt Stoepel
  • Patent number: 4110472
    Abstract: N-Diphenylmethyl and o-biphenylenemethyl derivatives of 1-(disubstituted phenoxy)-3-amino-2-hydroxypropane and their salts are useful for combatting cerebrovascular insufficiency and producing psychostimulation in humans and other animals. The compounds, of which 1-(2-methoxy-4-allylphenoxy)-2-hydroxy-3-diphenylmethylamino-propane is a typical embodiment, can be prepared by a number of synthetic routes.
    Type: Grant
    Filed: October 13, 1976
    Date of Patent: August 29, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Hiltmann, Arend Heise, Stanislav Kazda, Friedrich Hoffmeister