Abstract: The present invention relates to a heteroaryl derivative compound and a use thereof. Since the heteroaryl derivative of the present invention exhibits excellent inhibitory activity against EGFR, the heteroaryl derivative can be usefully used as a therapeutic agent for EGFR-associated diseases.

Abstract: A storage device is provided. The storage device includes a controller which receives a command from a host for instructing performance of a first computation, a non-volatile memory which stores a plurality of datasets, a buffer memory to which a first dataset among the plurality of datasets stored in the non-volatile memory is provided in response to the command, and an accelerator which performs the first computation corresponding to the command, using the first dataset provided to the buffer memory. The accelerator includes a memory access module which receives a first input query for instructing the first computation and the first dataset from the buffer memory, and a first computing module which is connected to the memory access module and determines first final candidate data corresponding to the first input query, using the first dataset.

Abstract: Disclosed is a method for producing soluble CRM197 protein at high yield by overexpressing the protein in the cytoplasm of E. coli. The method includes a step of culturing recombinant E. coli harboring an expression plasmid carrying a gene sequence coding for a recombinant CRM197 protein under a condition suitable for expression of the recombinant CRM197 protein which has a histidine-tag attached to the C-terminus of CRM197 and a maltose-binding protein (MBP) attached to the N-terminus of CRM197. The method further includes a step of purifying after the culturing, wherein the step of purifying comprises a step of treating with tobacco etch virus (TEV) protease to remove the maltose-binding protein and a step of removing the histidine-tag via histidine-tag affinity chromatography.

Abstract: Disclosed is a method for expressing and purifying insoluble proteins of CRM197. The method includes: culturing a transformant transformed with an expression vector containing a gene encoding CRM197 protein; obtaining a culture of the transformant and disrupting the cell to recover an inclusion body; solubilizing the inclusion body; treating the solubilized inclusion body with a refolding reaction mixture and performing a refolding process; and purifying the refolded CRM197 protein by chromatography.

Abstract: Provided is an electrode device for analyzing a biomaterial, which includes: an electrode portion having a plurality of electrodes arranged spaced apart from a plate-shaped substrate and a biomaterial input portion formed on the substrate to be electrically connected to at least one of the plurality of electrodes; a housing having an electrode accommodation portion having one side open and accommodating the electrode portion; a printed circuit board fixed to the housing; a connector portion formed on one end portion of the printed circuit board and electrically and detachably coupled to an analysis apparatus; connection pillars electrically connected to the connector portion and having one end portion fixed to the printed circuit board and the other end portion formed to be in pressure contact with the electrode portion, wherein the connection pillars includes an electrically conductive material and is arranged to correspond to the plurality of electrodes; and an input hole penetrating through an upper surfac

Abstract: Disclosed is a method for producing soluble CRM197 protein at high yield by overexpressing the protein in the cytoplasm of E. coli. The method includes a step of culturing recombinant E. coli harboring an expression plasmid carrying a gene sequence coding for a recombinant CRM197 protein under a condition suitable for expression of the recombinant CRM197 protein which has a histidine-tag attached to the C-terminus of CRM197 and a maltose-binding protein (MBP) attached to the N-terminus of CRM197. The method further includes a step of purifying after the culturing, wherein the step of purifying comprises a step of treating with tobacco etch virus (TEV) protease to remove the maltose-binding protein and a step of removing the histidine-tag via histidine-tag affinity chromatography.

Abstract: A display apparatus for a mobile terminal including: an input unit for receiving a user's instruction; a controller for simultaneously executing two or more tasks and transferring the received instruction to at least one display unit; a first display unit for performing displaying according to the received instruction; and a second display unit placed at a position where a user can view it together with the first display unit. The mobile terminal can simultaneously process a plurality of tasks through a plurality of display units to allow the user to perform multitasking substantially.

Abstract: A display apparatus for a mobile terminal including: an input unit for receiving a user's instruction; a controller for simultaneously executing two or more tasks and transferring the received instruction to at least one display unit; a first display unit for performing displaying according to the received instruction; and a second display unit placed at a position where a user can view it together with the first display unit. The mobile terminal can simultaneously process a plurality of tasks through a plurality of display units to allow the user to perform multitasking substantially.