Abstract: The invention relates to the use of a cyclic glycopeptide to enhance the resistance of a composition to one or more of a tensile, shear and torsional force, where the composition comprises a bone substitute powder, an aqueous liquid and the cyclic glycopeptide. The invention also relates to a composition for use in the treatment of a musculoskeletal disorder in a mammal receiving an implant to enhance bone re-growth for stabilization of the implant, and to a method for the use of the composition in treatment of the mammal. The composition comprises a bone substitute powder, an aqueous liquid and a cyclic glycopeptide.