Patents by Inventor Ariana Barbera Betancourt

Ariana Barbera Betancourt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inducing T cell apoptosis by administering Altered Peptide Ligand
    Patent number: 8410057
    Abstract: The present invention is related with the field of the medicine, particularly with the use of an APL peptide or its analogues derived from the human heat shock protein of 60 kDa, for the manufacture of a pharmaceutical composition for the treatment of Crohn's disease, ulcerative colitis and diabetes mellitus type 1. This peptide is biodistributed into the gastrointestinal tract and also promotes the induction of apoptosis in activated intestinal lamina propria and peripheral blood T cells of patients with Crohn's disease. Furthermore, this peptide induces apoptosis in mononuclear cells of patients with diabetes mellitus type 1.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: April 2, 2013
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Ariana Barbera Betancourt, Maria del Carmen Dominguez Horta, Norailys Lorenzo Perez, Gabriel Ramon Padron Palomares, Viviana Falcon Cama, Ivon Menendez Valdes
  • Altered peptide ligand derived from HSP60 and pharmaceutical compositions
    Patent number: 8383771
    Abstract: Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
    Type: Grant
    Filed: September 22, 2005
    Date of Patent: February 26, 2013
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Maria del Carmen Dominguez Horta, Gabriel Ramón Padrón Palomares, Nelia López Marin, Norailys Lorenzo Perez, Ariana Barberá Betancourt, Ariadna Hernández Garcia, Vivian Morera Cordova, Carelia Cosme Diaz, Nelson J. Merino Garcia, Ariel Vázquez Bonachea, José Suárez Alba
  • Peptides and altered peptide ligands derived from HSP60 and pharmaceutical compositions
    Patent number: 8324164
    Abstract: Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: December 4, 2012
    Assignee: Centro de Ingenieria Genetica Y Biotecnologia
    Inventors: Maria del Carmen Domínguez Horta, Gabriel Ramón Padrón Palomares, Nelia López Marin, Norailys Lorenzo Perez, Ariana Barberá Betancourt, Ariadna Hernández Garcia, Vivian Morera Cordova, Carelia Cosme Diaz, Nelson J. Merino Garcia, Ariel Vázquez Bonachea, José Suárez Alba
  • USE OF APL-TYPE PEPTIDE FOR TREATING INTESTINAL INFLAMMATORY DISEASES AND TYPE 1 DIABETES
    Publication number: 20120035106
    Abstract: The present invention is related with the field of the medicine, particularly with the use of an APL peptide or its analogues derived from the human heat shock protein of 60 kDa, for the manufacture of a pharmaceutical composition for the treatment of Crohn's disease, ulcerative colitis and diabetes mellitus type 1. This peptide is biodistributed into the gastrointestinal tract and also promotes the induction of apoptosis in activated intestinal lamina propria and peripheral blood T cells of patients with Crohn's disease. Furthermore, this peptide induces apoptosis in mononuclear cells of patients with diabetes mellitus type 1.
    Type: Application
    Filed: December 29, 2009
    Publication date: February 9, 2012
    Inventors: Ariana Barbera Betancourt, Maria del Carmen Dominguez Horta, Norailys Lorenzo Perez, Gabriel Ramon Padron Palomares, Viviana Falcon Cama, Ivon Menendez Valdes
  • PEPTIDES AND APL-TYPE DERIVATIVES OF HSP60 AND PHARMACEUTICAL COMPOSITIONS
    Publication number: 20100144642
    Abstract: Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
    Type: Application
    Filed: December 30, 2009
    Publication date: June 10, 2010
    Applicant: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
    Inventors: María del Carmen Domínguez Horta, Gabriel Ramón Padrón Palomares, Nelia López Marín, Norailys Lorenzo Perez, Ariana Barberá Betancourt, Ariadna Hernández Garcia, Vivian Morera Cordova, Carelia Cosme Díaz, Nelson J. Merino García, Ariel Vázquez Bonachea, José Suárez Alba
  • Peptides And Apl-Type Derivatives Of Hsp60 And Pharmaceutical Compositions
    Publication number: 20090171069
    Abstract: Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
    Type: Application
    Filed: September 22, 2005
    Publication date: July 2, 2009
    Inventors: Maria del Carmen Dominguez Horta, Gabriel Ramon Padron Palomares, Nelia Lopez Marin, Norailys Lorenzo Perez, Ariana Barbera Betancourt, Ariadna Hernandez Garcia, Vivian Morera Cordova, Carelia Cosme Diaz, Nelson J. Merino Garcia, Ariel Vazquez Bonachea, Jose Suarez Alba