Patents by Inventor Arie J. Zuckerman

Arie J. Zuckerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for purifying hepatitis A virus (HAV), virus thus purified and vaccine compositions containing it
    Patent number: 5719049
    Abstract: A process is described for the purification or the hepatitis A virus, which allows one to obtain with good yields a pure product, in which organic material collected by centrifugation after lysis or the culture cells is submitted to gel filtration and successively to ion exchange chromatography.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: February 17, 1998
    Assignee: Chiron S.p.A.
    Inventors: Vittoria Pellegrini, Nicoletta Fineschi, Arie J. Zuckerman
  • Process for purifying hepatitis a virus (HAV), and vaccine compositions containing hepatitis a virus
    Patent number: 5607851
    Abstract: A process is described for the purification of the hepatitis A virus, which allows one to obtain with good yields a pure product, in which organic material collected by centrifugation after lysis of the culture cells is submitted to gel filtration and successively to ion exchange chromatography.
    Type: Grant
    Filed: July 18, 1994
    Date of Patent: March 4, 1997
    Assignee: Biocine S.p.A.
    Inventors: Vittoria Pellegrini, Nicoletta Fineschi, Arie J. Zuckerman
  • Relating to hepatitis B vaccine
    Patent number: 4666713
    Abstract: Immunogenically active fragments of hepatitis B surface antigen, which are a glycoprotein of molecular weight about 28,000 (gp 28) and a protein of molecular weight about 23,000 (p 23), obtained by known methods by treatment of surface antigen with detergent, are prepared in micelle form substantially free from detergent. The micelles are at least as immunogenic as the unfragmented antigen from which they are derived and are useful in the preparation of hepatitis B vaccine. The detergent is removed by layering the detergent containing fragmentation product on an aqueous buffer containing a sucrose gradient and centrifuging the layered buffer when micelles containing both gp 28 and p 23 form and can be recovered in substantially detergent free form from the centrifuged layered buffer.
    Type: Grant
    Filed: September 6, 1985
    Date of Patent: May 19, 1987
    Assignee: National Research Development Corporation
    Inventors: Jacinta Skelly, Colin R. Howard, Arie J. Zuckerman
  • Hepatitis B vaccine
    Patent number: 4554157
    Abstract: Immunogenically active fragments of hepatitis B surface antigen, which are a glycoprotein of molecular weight about 28,000 (gp 28) and a protein of molecular weight about 23,000 (p 23), obtained by known methods by treatment of surface antigen with detergent, are prepared in micelle form substantially free from detergent. The micelles are at least as immunogenic as the unfragmented antigen from which they are derived and are useful in the preparation of hepatitis B vaccine. The detergent is removed by layering the detergent containing fragmentation product on an aqueous buffer containing a sucrose gradient and centrifuging the layered buffer when micelles containing both gp 28 and p 23 form and can be recovered in substantially detergent free form from the centrifuged layered buffer.
    Type: Grant
    Filed: May 29, 1984
    Date of Patent: November 19, 1985
    Assignee: National Research Development Corporation
    Inventors: Jacinta Skelly, Colin R. Howard, Arie J. Zuckerman