Patents by Inventor Arie Lev

Arie Lev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10787423
    Abstract: Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's and Parkinson's diseases.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: September 29, 2020
    Assignee: THE NATIONAL INSTITUTE FOR BIOTECHNOLGY IN THE NEGEV LTD.
    Inventors: Varda Shoshan-Barmatz, Arie Lev Gruzman
  • Publication number: 20200181094
    Abstract: Provided herein are novel barbituric acid derivatives, their synthesis and use thereof in blocking leukocyte transmigration. The novel barbituric acid derivatives are useful for the treatment of disorders associated with leukocyte transmigration, such as for example inflammatory diseases and disorders, autoimmune diseases and disorders, and cancers.
    Type: Application
    Filed: August 30, 2018
    Publication date: June 11, 2020
    Inventors: Arie Lev GRUZMAN, Paul BRADFIELD, Tamar GETTER, Beat IMHOF, Thomas MATTHES, Hanoch SENDEROWITZ
  • Patent number: 10674626
    Abstract: The invention relates to a master-slave power supply system, which comprises: (a) a master power supply unit having an output power port; (b) one or more slave units, each unit having its own power port; wherein the output power port of the master unit, as well as the output ports of all the slave units are connected in parallel; and wherein a bridging cable connects between the master unit and a first slave unit, and additional bridging cables connect respectively each of the slave units to a next one, until a last slave unit, and wherein at least a voltage feedback signal is conveyed from master unit to all the slave units in parallel over said bridging cables.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: June 2, 2020
    Assignee: TDK-LAMBDA LTD
    Inventors: Jakob Vatariu, Arie Lev Girshson
  • Publication number: 20200115348
    Abstract: Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's and Parkinson's diseases.
    Type: Application
    Filed: November 4, 2019
    Publication date: April 16, 2020
    Inventors: Varda SHOSHAN-BARMATZ, Arie LEV GRUZMAN
  • Publication number: 20200000801
    Abstract: The present invention relates to use of small organic compounds interacting with the Voltage-Dependent Anion Channel (VDAC) for the treatment of diseases associated with central nervous system (CNS) disorders, including psychotic disorders, mood disorders, neurodegenerative diseases. In particular the present invention relates to the use of substituted piperazine- and piperidine-derivatives and pharmaceutical compositions comprising same for the treatment of psychotic disorders including schizophrenia, mood disorders, and neurodegenerative diseases.
    Type: Application
    Filed: September 4, 2019
    Publication date: January 2, 2020
    Inventors: Varda SHOSHAN-BARMATZ, Arie LEV GRUZMAN
  • Patent number: 10508091
    Abstract: Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's disease.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: December 17, 2019
    Assignee: THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
    Inventors: Varda Shoshan-Barmatz, Arie Lev Gruzman
  • Patent number: 10434099
    Abstract: The present invention relates to use of small organic compounds interacting with the Voltage-Dependent Anion Channel (VDAC) for the treatment of diseases associated with central nervous system (CNS) disorders, including psychotic disorders, mood disorders, neurodegenerative diseases. In particular the present invention relates to the use of substituted piperazine- and piperidine-derivatives and pharmaceutical compositions comprising same for the treatment of psychotic disorders including schizophrenia, mood disorders, and neurodegenerative diseases.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: October 8, 2019
    Assignee: The National Institute for Biotechnology in the Negev Ltd.
    Inventors: Varda Shoshan-Barmatz, Arie Lev Gruzman
  • Publication number: 20190037723
    Abstract: The invention relates to a master-slave power supply system, which comprises: (a) a master power supply unit having an output power port; (b) one or more slave units, each unit having its own power port; wherein the output power port of the master unit, as well as the output ports of all the slave units are connected in parallel; and wherein a bridging cable connects between the master unit and a first slave unit, and additional bridging cables connect respectively each of the slave units to a next one, until a last slave unit, and wherein at least a voltage feedback signal is conveyed from master unit to all the slave units in parallel over said bridging cables.
    Type: Application
    Filed: September 1, 2017
    Publication date: January 31, 2019
    Applicant: TDK-LAMBDA LTD
    Inventors: Jakob Vatariu, Arie Lev Girshson
  • Publication number: 20180118700
    Abstract: Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's disease.
    Type: Application
    Filed: September 13, 2016
    Publication date: May 3, 2018
    Inventors: Varda SHOSHAN-BARMATZ, Arie LEV GRUZMAN
  • Publication number: 20180078548
    Abstract: The present invention relates to use of small organic compounds interacting with the Voltage-Dependent Anion Channel (VDAC) for the treatment of diseases associated with central nervous system (CNS) disorders, including psychotic disorders, mood disorders, neurodegenerative diseases. In particular the present invention relates to the use of substituted piperazine- and piperidine-derivatives and pharmaceutical compositions comprising same for the treatment of psychotic disorders including schizophrenia, mood disorders, and neurodegenerative diseases.
    Type: Application
    Filed: September 11, 2017
    Publication date: March 22, 2018
    Inventors: Varda SHOSHAN-BARMATZ, Arie LEV GRUZMAN
  • Patent number: 9409904
    Abstract: The present invention is directed to compounds such as: formula wherein linker is independently selected from the group consisting of —S—, —S—S—, —S—(CH2)n-, —NH—, —NH—(CH2)n-, —O—, —SO2-, arylene, heteroarylene; R1 is selected from the group consisting of straight or branched C4-C20 alkyl, straight or branched C4-C20 alkenyl, straight or branched C4-C20 alkynyl, each optionally interrupted with at least one NH, C5-C7 saturated cycloalkyl or heteroalkyl ring, C5-C12 aromatic or heteroaromatic ring, each optionally substituted with at least one group selected from —COOH, —NH2, C1-C8 alkoxy, C1-C5 amidyle, C1-C5 carboxyl, halogen; and R2 is independently selected from the group consisting of H, OH, SH, NH2, NO2, halogen, CN, C1-C8 alkoxy, C1-C5 carboxylic acid, straight or branched C1-C8 alkyl, straight or branched C2-C10 alkenyl, straight or branched C2-C12 alkynyl each optionally substituted by at least one substituent selected from the group consisting of C1-C5 alkoxy, C1-C5 carboxylic acid, OH, SH, NH2, hal
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: August 9, 2016
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD, DIAB R&D 1, BAR ILAN UNIVERSITY
    Inventors: Shlomo Sasson, Erol Cerasi, Arie Lev Gruzman, Ella Meltzer-Mats
  • Publication number: 20150025094
    Abstract: The present invention is directed to compounds such as: formula wherein linker is independently selected from the group consisting of —S—, —S—S—, —S—(CH2)n—, —NH—, —NH—(CH2)n—, —O—, —S02-, arylene, heteroarylene; R1 is selected from the group consisting of straight or branched C4-C20 alkyl, straight or branched C4-C20 alkenyl, straight or branched C4-C20 alkynyl, each optionally interrupted with at least one NH, C5-C7 saturated cycloalkyl or heteroalkyl ring, C5-C12 aromatic or heteroaromatic ring, each optionally substituted with at least one group selected from —COOH, —NH2, C1-C8 alkoxy, C1-C5 amidyle, C1-C5 carboxyl, halogen; and R2 is independently selected from the group consisting of H, OH, SH, NH2, NO2, halogen, CN, C1-C8 alkoxy, C1-C5 carboxylic acid, straight or branched C1-C8 alkyl, straight or branched C2-C10 alkenyl, straight or branched C2-C12 alkynyl each optionally substituted by at least one substituent selected from the group consisting of C1-C5 alkoxy, C1-C5 carboxylic acid, OH, SH, NH2, hal
    Type: Application
    Filed: August 1, 2012
    Publication date: January 22, 2015
    Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., DIAB R&d 1, BAR-IIan University
    Inventors: Shlomo Sasson, Erol Cerasi, Arie Lev Gruzman, Ella Meltzer-Mats
  • Publication number: 20110248678
    Abstract: A method and apparatus for the intelligent management of multi-cell battery pack. A battery management system which may be mounted on board a vehicle facilitates battery management including monitoring the state of charge of the battery pack. Wireless communication equipment facilitate communication between the battery management system to a remote location. A battery charger controlled by the battery management system charges individual cells of the battery pack.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 13, 2011
    Applicant: GRRREEN, Inc., a Delaware corporation
    Inventors: John M. Wade, Shalom Arie Lev
  • Patent number: 8036321
    Abstract: Control systems and methods for independent control of power systems, particularly lighting network branches, and separate control of individual branch components. Multi-branch systems comprise independently controllable branches that inter-communicate via PLC communications. In each branch, components such as ballasts, local control units, sensors, actuators, and repeaters, may exchange commands and queries independently of a branch remote control unit (BRCU). Alternatively, a BRCU may manage or arbitrate communications, or interact with other BRCUs, other control units and external management systems. Ballasts include a multi-channel ballast that enables close-loop control of individual fixtures, or of individual dimmable or non-dimmable lamps within a fixture. The close-loop control is facilitated by sampling circuits/sensors co-located with each controlled fixture or lamp. All controllers are preferably implemented using an integrated digital controller.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: October 11, 2011
    Assignee: S.T.L. Energy Solutions and Technologies Ltd.
    Inventors: Rafael Mogilner, Boris Nogtev, Yuri Kuhlik, Daniel Rubin, Arie Lev, Eytan Rabinovitz
  • Publication number: 20100052731
    Abstract: Control systems and methods for independent control of power systems, particularly lighting network branches, and separate control of individual branch components. Multi-branch systems comprise independently controllable branches that inter-communicate via PLC communications. In each branch, components such as ballasts, local control units, sensors, actuators, and repeaters, may exchange commands and queries independently of a branch remote control unit (BRCU). Alternatively, a BRCU may manage or arbitrate communications, or interact with other BRCUs, other control units and external management systems. Ballasts include a multi-channel ballast that enables close-loop control of individual fixtures, or of individual dimmable or non-dimmable lamps within a fixture. The close-loop control is facilitated by sampling circuits/sensors co-located with each controlled fixture or lamp. All controllers are preferably implemented using an integrated digital controller.
    Type: Application
    Filed: July 7, 2009
    Publication date: March 4, 2010
    Applicant: Systel Development & Industries Ltd.
    Inventors: RAFAEL MOGILNER, BORIS NOGTEV, YURI KUHLIK, DANIEL RUBIN, ARIE LEV, EYTAN RABINOVITZ
  • Publication number: 20090299500
    Abstract: An integrated digital controller for controlling power electronic devices and method of its use, comprises an analog-to-digital converting scanner module for scanning analog data inputs and used to create digital data correlated with the analog inputs, a loop control module operative to receive the digital data ad used for controlling at least one control loop, and a pulse sequence generator (PSG) module used for generating a variety of fast, configurable, event-driven pulse sequences in cooperation with the PSG and scanner modules. The controller comprises optionally a CPU for managing various tasks and coordinate between the modules, means to create the events, and means for configuration and reconfiguration on-the-fly. The controller is preferably integrated in a semiconductor chip.
    Type: Application
    Filed: June 3, 2009
    Publication date: December 3, 2009
    Applicant: Systel Development & Industries Ltd.
    Inventors: Daniel RUBIN, Arie LEV, Eytan RABINOVITZ, Rafael MOGILNER
  • Patent number: 7573372
    Abstract: Control systems and methods for independent control of power systems, particularly lighting network branches, and separate control of individual branch components. Multi-branch systems comprise independently controllable branches that inter-communicate via PLC communications. In each branch, components such as ballasts, local control units, sensors, actuators, and repeaters, may exchange commands and queries independently of a branch remote control unit (BRCU). Alternatively, a BRCU may manage or arbitrate communications, or interact with other BRCUs, other control units and external management systems. Ballasts include a multi-channel ballast that enables close-loop control of individual fixtures, or of individual dimmable or non-dimmable lamps within a fixture. The close-loop control is facilitated by sampling circuits/sensors co-located with each controlled fixture or lamp. All controllers are preferably implemented using an integrated digital controller.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: August 11, 2009
    Assignee: Systel Development & Industries Ltd.
    Inventors: Rafael Mogilner, Boris Nogtev, Yuri Kuhlik, Daniel Rubin, Arie Lev, Eytan Rabinovitz
  • Patent number: 7557663
    Abstract: A digital phase locked loop (DPLL) comprising a digitally implemented voltage controlled oscillator (VCO) for producing a VCO feedback signal, a phase error counter which includes a digital phase-frequency detector for producing a first phase error signal, a quadrature phase detector for producing a second phase error signal and an adder for adding the first and second phase error signals to obtain a combined phase error signal, and two programmable dividers used to cooperatively determine the VCO feedback signal and to provide a DPLL output line sync value synchronized with an input signal.
    Type: Grant
    Filed: June 17, 2007
    Date of Patent: July 7, 2009
    Assignee: Systel Development & Industries Ltd.
    Inventors: Daniel Rubin, Arie Lev, Eytan Rabinovitz, Rafael Mogilner
  • Patent number: 7449844
    Abstract: A programmable digital power controller for gas discharge devices such as fluorescent lamps or other devices using all digital internal and external programmable controls. A specific ASIC is described. A gate array and microcomputer share parallel functions with fast sub-functions carried out by the gate array and slower sub-functions carried out by a micro-processor. Circuits are provided for automatic shut down when a high frequency ground fault is detected; for connecting the filaments of multiple gas discharge devices in a series/parallel circuit in a manner that power for a particular device is disabled when that device is removed from the circuit; for driving the load as close to resonance as possible but in an inductive mode; and for developing a dead time between high side and low side switches which is related to transformer current, switch current, bridge voltage or bridge voltage dv/dt.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: November 11, 2008
    Assignee: Systel Development + Industries Ltd.
    Inventors: Arie Lev, Rafael Mogilner, Daniel Rubin, Yoel Sharaby, Moshe Kalichstein
  • Publication number: 20080205104
    Abstract: A programmable digital power controller for gas discharge devices such as fluorescent lamps or other devices using all digital internal and external programmable controls. A specific ASIC is described. A gate array and microcomputer share parallel functions with fast sub-functions carried out by the gate array and slower sub-functions carried out by a micro-processor. Circuits are provided for automatic shut down when a high frequency ground fault is detected; for connecting the filaments of multiple gas discharge devices in a series/parallel circuit in a manner that power for a particular device is disabled when that device is removed from the circuit; for driving the load as close to resonance as possible but in an inductive mode; and for developing a dead time between high side and low side switches which is related to transformer current, switch current, bridge voltage or bridge voltage dv/dt.
    Type: Application
    Filed: January 27, 2008
    Publication date: August 28, 2008
    Applicant: Systel Development & Industries Ltd.
    Inventors: Arie Lev, Rafael Mogilner, Daniel Rubin, Yoel Sharaby, Moshe Kalichstein