Patents by Inventor Arie Marcovich

Arie Marcovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (BACTERIO)CHLOROPHYLL PHOTOSENSITIZERS FOR TREATMENT OF EYE DISEASES AND DISORDERS
    Publication number: 20210330792
    Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.
    Type: Application
    Filed: July 8, 2021
    Publication date: October 28, 2021
    Inventors: Avigdor SCHERZ, Yoram SALOMON, Arie MARCOVICH, Alexander BRANDIS, Daniel WAGNER
  • Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
    Patent number: 11077128
    Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: August 3, 2021
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Steven J. D. Karlish, Adriana Katz, Daniel M. Tal, Arie Marcovich
  • (Bacterio)chlorophyll photosensitizers for treatment of eye diseases and disorders
    Patent number: 11058772
    Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: July 13, 2021
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Avigdor Scherz, Yoram Salomon, Arie Marcovich, Alexander Brandis, Daniel Wagner
  • SELECTIVE INHIBITORS OF Alpha2-CONTAINING ISOFORMS OF Na,K-ATPase AND USE THEREOF FOR REDUCTION OF INTRAOCULAR PRESSURE
    Publication number: 20200297748
    Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.
    Type: Application
    Filed: April 14, 2020
    Publication date: September 24, 2020
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Steven J.D. KARLISH, Adriana KATZ, Daniel M. TAL, Arie MARCOVICH
  • Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
    Patent number: 10668094
    Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: June 2, 2020
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Steven J. D. Karlish, Adriana Katz, Daniel M. Tal, Arie Marcovich
  • (BACTERIO)CHLOROPHYLL PHOTOSENSITIZERS FOR TREATMENT OF EYE DISEASES AND DISORDERS
    Publication number: 20190231874
    Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.
    Type: Application
    Filed: November 20, 2018
    Publication date: August 1, 2019
    Inventors: Avigdor SCHERZ, Yoram SALOMON, Arie MARCOVICH, Alexander BRANDIS, Daniel WAGNER
  • SELECTIVE INHIBITORS OF Alpha2-CONTAINING ISOFORMS OF Na,K-ATPase AND USE THEREOF FOR REDUCTION OF INTRAOCULAR PRESSURE
    Publication number: 20180207189
    Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.
    Type: Application
    Filed: July 19, 2016
    Publication date: July 26, 2018
    Inventors: Steven J.D. KARLISH, Adriana KATZ, Daniel M. TAL, Arie MARCOVICH
  • Selective inhibitors of ?2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure and as cardiotonic agents
    Patent number: 9938316
    Abstract: The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the ?2 isoform of Na,K-ATPase, and that reduce intra-ocular pressure. The invention further relates to uses of these derivatives for treating disorders associated with elevated intraocular pressure, such as glaucomas, and/or as cardiotonic agents.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: April 10, 2018
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Steven J. D. Karlish, Adriana Katz, Daniel M. Tal, Arie Marcovich
  • Hyper-osmotic eye contact lens
    Patent number: 9927632
    Abstract: A hyper-osmotic contact lens including a contact lens including a central convex disc, a peripheral curved portion that extends radially from the disc, an annular groove formed in the disc and one or more apertures formed in the groove.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: March 27, 2018
    Assignee: Eyeyon Medical Ltd.
    Inventors: Ofer Daphna, Arie Marcovich, Soheil Shaer, Nahum Ferera
  • KERATOPROSTHESIS
    Publication number: 20170265991
    Abstract: A keratoprosthesis includes an anterior collagen layer made of transparent synthetic collagen, and a hydrophobic posterior layer, an anterior surface of the posterior layer being posterior of an anterior surface of the collagen layer.
    Type: Application
    Filed: June 1, 2017
    Publication date: September 21, 2017
    Applicant: EyeYon Medical Ltd.
    Inventors: Ofer Daphna, Arie Marcovich, Guy Oren, Nahum Ferera
  • CONTACT LENS
    Publication number: 20170143540
    Abstract: A method for drug delivery includes placing a contact lens over a cornea of an eye. The contact lens includes a central convex disc, a peripheral curved portion that extends radially from the disc, an annular groove formed in the disc, and one or more apertures formed in the groove. An inner volume of the lens defines a chamber. A drug substance is placed in the chamber, which traps the drug substance therein for a period of time.
    Type: Application
    Filed: February 2, 2017
    Publication date: May 25, 2017
    Applicant: EyeYon Medical Ltd.
    Inventors: Ofer Daphna, Arie Marcovich, Soheil Shaer, Nahum Ferera
  • HYPER-OSMOTIC EYE CONTACT LENS
    Publication number: 20170031180
    Abstract: A hyper-osmotic contact lens including a contact lens including a central convex disc, a peripheral curved portion that extends radially from the disc, an annular groove formed in the disc and one or more apertures formed in the groove.
    Type: Application
    Filed: July 31, 2015
    Publication date: February 2, 2017
    Inventors: Ofer Daphna, Arie Marcovich, Soheil Shaer, Nahum Ferera
  • (BACTERIO)CHLOROPHYLL PHOTOSENSITIZERS FOR TREATMENT OF EYE DISEASES AND DISORDERS
    Publication number: 20160354468
    Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.
    Type: Application
    Filed: August 18, 2016
    Publication date: December 8, 2016
    Inventors: Avigdor SCHERZ, Yoram SALOMON, Arie MARCOVICH, Alexander BRANDIS, Daniel WAGNER
  • (Bacterio)chlorophyll photosensitizers for treatment of eye diseases and disorders
    Patent number: 9452172
    Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: September 27, 2016
    Assignee: Yeda Research and Development Co. LTD.
    Inventors: Avigdor Joshua Scherz, Yoram Salomon, Arie Marcovich, Alexander Brandis, Daniel Wagner
  • KERATOPROSTHESIS
    Publication number: 20160184084
    Abstract: A keratoprosthesis includes an anterior collagen layer made of transparent synthetic collagen, and a hydrophobic posterior layer, an anterior surface of the posterior layer being posterior of an anterior surface of the collagen layer.
    Type: Application
    Filed: December 29, 2014
    Publication date: June 30, 2016
    Inventors: Ofer Daphna, Arie Marcovich, Guy Oren, Nahum Ferera
  • (BACTERIO)CHLOROPHYLL PHOTOSENSITIZERS FOR TREATMENT OF EYE DISEASES AND DISORDERS
    Publication number: 20140378888
    Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies such as corneal thinning and scleral stretching.
    Type: Application
    Filed: August 23, 2012
    Publication date: December 25, 2014
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Avigdor Scherz, Yoram Salomon, Arie Marcovich, Alexander Brandis, Daniel Wagner