Patents by Inventor Arie Zask

Arie Zask has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • WORTMANNIN-RAPAMYCIN CONJUGATE AND USES THEREOF
    Publication number: 20080249123
    Abstract: A rapamycin—wortmannin conjugate is described, in which the conjugate is formed by linking the rapamycin and wortmannin together in such a manner that the rapamycin and the wortmannin are separated following administration to a subject. Use of such a conjugate in an antineoplastic regimen is described.
    Type: Application
    Filed: April 3, 2008
    Publication date: October 9, 2008
    Applicant: Wyeth
    Inventors: JIANXIN GU, Ker Yu, Judy Lucas, Mark Ruppen, Arie Zask, Semiramis Ayral-Kaloustian
  • IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS
    Publication number: 20080233127
    Abstract: The present invention relates to Imidazolopyrimidine Analogs, methods of making Imidazolopyrimidine Analogs, compositions comprising an Imidazolopyrimidine Analog, and methods for treating or preventing a PI3K-related disorder comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog. The invention also relates to methods for treating or preventing mTOR-related disorders comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog.
    Type: Application
    Filed: March 7, 2008
    Publication date: September 25, 2008
    Applicant: Wyeth
    Inventors: Matthew Gregory Bursavich, Aranapakam Mudumbai Venkatesan, Pawel Wojciech Nowak, Sabrina Lombardi, Adam Matthew Gilbert, Christoph Martin Denhardt, Osvaldo Dos Santos, Efren Guillermo Delos Santos, Natasja Brooijmans, Semiramis Ayral-Kaloustian, Zecheng Chen, Jeroen Cunera Verheijen, Joshua Kaplan, Arie Zask
  • PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS
    Publication number: 20080234262
    Abstract: The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog. The invention also relates to treating PI3K-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog.
    Type: Application
    Filed: March 18, 2008
    Publication date: September 25, 2008
    Applicant: Wyeth
    Inventors: Arie Zask, Pawel Wojciech Nowak, Jeroen Cunera Verheijen, Kevin J. Curran, Joshua Kaplan, David Malwitz, Matthew Gregory Bursavich, Derek Cecil Cole, Semiramis Ayral-Kaloustian, Ker Yu, David James Richard, Mark Lefever
  • COMPOUNDS FOR TREATING TUMORS
    Publication number: 20080221181
    Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
    Type: Application
    Filed: April 17, 2008
    Publication date: September 11, 2008
    Applicant: Wyeth Holdings Corporation
    Inventors: Arie Zask, Joshua Kaplan, Ayako Yamashita, Chuan S. Niu, Gary Harold Birnberg, Emily Norton, Kinwang Cheung, Ronald Suayan, Vincent Sandanayaka, Philip Ross Hamann, Semiramis Ayral-Kaloustian
  • Compounds for treating tumors
    Patent number: 7390910
    Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: June 24, 2008
    Assignee: Wyeth
    Inventors: Arie Zask, Joshua Kaplan, Ayako Yamashita, Chuan S. Niu, Gary Harold Birnberg, Emily Norton, Kinwang Cheung, Ronald Suayan, Vincent Sandanayaka, Philip Ross Hamann, Semiramis Ayral-Kaloustian
  • Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof
    Publication number: 20080085890
    Abstract: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.
    Type: Application
    Filed: March 26, 2007
    Publication date: April 10, 2008
    Applicant: Wyeth
    Inventors: Hwei-Ru Tsou, Semiramis Ayral-Kaloustian, Gary Birnberg, Middleton Floyd, Joshua Kaplan, Kristina Kutterer, Xiaoxiang Liu, Ramaswamy Nilakantan, Mercy Otteng, Zhilian Tang, Arie Zask, Tritin Tran, Scott Mayer, Annette Banker, Marvin Reich
  • Hemiasterlin affinity probes and their uses
    Publication number: 20070026478
    Abstract: Photoaffinity probes are provided that are based hemiasterlin and derivative compounds thereof. Use of these probes to identity ending sites for these and other drugs, particularly anti-tubulin drugs, are also provided as are methods for identifying new drugs (e.g., new anti-tubulin drugs) that bind to these binding sites.
    Type: Application
    Filed: November 21, 2003
    Publication date: February 1, 2007
    Applicant: WYETH
    Inventors: Lee Greenberger, Malathi Hari, Maria Nunes, Semiramis Ayral-Kaloustian, Arie Zask, Joseph Wooters
  • Analogs of 17-hydroxywortmannin as P13K inhibitors
    Publication number: 20060128793
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, and R8 are defined herein.
    Type: Application
    Filed: October 13, 2005
    Publication date: June 15, 2006
    Applicant: Wyeth
    Inventors: Arie Zask, Ping Cai, Jianxin Gu, Joshua Kaplan, Ker Yu, Tianmin Zhu
  • Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
    Patent number: 6946473
    Abstract: Compounds of the formula which are useful in disease conditions mediated by TNF-?, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: September 20, 2005
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, James M. Chen, Xue-Mei Du, Jay D. Albright, Arie Zask
  • Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors
    Publication number: 20050085504
    Abstract: Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.
    Type: Application
    Filed: November 4, 2004
    Publication date: April 21, 2005
    Applicant: WYETH
    Inventors: Frances Nelson, Arie Zask, James Chen, Dominick Mobilio, Ramaswamy Nilakantan
  • Compounds for treating tumors
    Publication number: 20050037977
    Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
    Type: Application
    Filed: August 4, 2004
    Publication date: February 17, 2005
    Applicant: Wyeth Holdings Corporation
    Inventors: Arie Zask, Joshua Kaplan, Ayako Yamashita, Chuan Niu, Gary Birnberg, Emily Norton, Kinwang Cheung, Ronald Suayan, Vincent Sandanayaka, Philip Hamann, Semiramis Ayral-Kaloustian
  • Preparation and use of ortho-sulfonamido arylhydroxamic acids as matrix metalloproteinase inhibitors
    Patent number: 6825352
    Abstract: Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: November 30, 2004
    Assignee: Wyeth
    Inventors: Frances Christy Nelson, Arie Zask, James Ming Chen, Dominick Mobilio, Ramaswamy Nilakantan
  • Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/TACE inhibitors
    Publication number: 20040229924
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: June 17, 2004
    Publication date: November 18, 2004
    Applicant: WYETH
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, James M. Chen, Arie Zask, Vincent P. Sandanayaka, Mila T. Du, Jannie L. Baker
  • Water soluble wortmannin derivatives
    Publication number: 20040213757
    Abstract: This invention relates to soluble derivatives of wortmannin that utilizes water-soluble polymers as carriers for a drug and includes compounds having the structures as described within the specification.
    Type: Application
    Filed: April 20, 2004
    Publication date: October 28, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Tianmin Zhu, Ker Yu, Judy Lucas, Jianxin Gu, Arie Zask
  • Method of treating resistant tumors
    Publication number: 20040121965
    Abstract: The invention provides a method of treating or inhibiting the growth of or eradicating a tumor in a mammal in need thereof wherein said tumor is resistant to at least one chemotherapeutic agent which method comprises providing to said mammal an effective amount of a compound of Formula II or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 18, 2003
    Publication date: June 24, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Lee Martin Greenberger, Frank Loganzo, Carolyn Mary Discafani-Marro, Arie Zask, Semiramis Ayral-Kaloustian
  • Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
    Patent number: 6753337
    Abstract: Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: June 22, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, James M. Chen, Arie Zask, Vincent P. Sandanayaka, Mila T. Du, Jannie L. Baker
  • Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
    Publication number: 20030208066
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: March 17, 2003
    Publication date: November 6, 2003
    Applicant: American Cyanamid Company
    Inventors: Jeremy I.. Levin, James Ming Chen, Xue-Mei Du, Jay D. Albright, Arie Zask
  • Bicyclic antagonists selective for the alphavbeta3 integrin
    Publication number: 20030109523
    Abstract: This invention provides novel bicyclic compounds of Formula (I): 1
    Type: Application
    Filed: June 6, 2002
    Publication date: June 12, 2003
    Applicant: Wyeth
    Inventors: Arie Zask, Diane B. Hauze, Kenneth L. Kees, Richard D. Coghlan, John Yardley
  • Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
    Patent number: 6548524
    Abstract: This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-&agr; converting enzyme (TACE. tumor necrosis factor-&agr; converting enzyme) which arc useful for the treatment of diseases in which these enzymes are implicated.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: April 15, 2003
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du
  • Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
    Patent number: 6534491
    Abstract: This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stroinelysins and collagenases) and TNF-&agr; converting enzyme (TACE, tumor necrosis factor-&agr;converting enzyme) which are useful for the treatment of diseases in which these enzymes are implicated.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: March 18, 2003
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du