Patents by Inventor Ariel G. Notcovich
Ariel G. Notcovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9829434Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.Type: GrantFiled: March 15, 2016Date of Patent: November 28, 2017Assignee: Bio-Rad Laboratories Inc.Inventors: Yochanan Uri, Boaz Ran, Ariel G. Notcovich, Shay Nimri
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Publication number: 20160299070Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.Type: ApplicationFiled: March 15, 2016Publication date: October 13, 2016Applicant: Bio-Rad Laboratories Inc.Inventors: Yochanan URI, Boaz RAN, Ariel G. NOTCOVICH, Shay NIMRI
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Patent number: 9354179Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.Type: GrantFiled: June 6, 2013Date of Patent: May 31, 2016Assignee: Bio-Rad Laboratories Inc.Inventors: Yochanan Uri, Boaz Ran, Ariel G. Notcovich, Shay Nimri
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Patent number: 8743367Abstract: An SPR or other optical resonance based analysis system in which, light is provided at multiple angles to a specimen and then the light modified by the specimen is processed to select only some of the light. Optionally, the processing selects light at a particular incidence angle. Optionally, the detection is by imaging of the light on a 2D imager array.Type: GrantFiled: May 21, 2008Date of Patent: June 3, 2014Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Tal Rosenzweig, Ariel G. Notcovich, Ariel Shemesh, Yochanan Uri, Michael Kanevsky, James W. Hillendahl, Barak Abraham Liraz
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Patent number: 8743369Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: GrantFiled: August 14, 2013Date of Patent: June 3, 2014Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Publication number: 20130330838Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: ApplicationFiled: August 14, 2013Publication date: December 12, 2013Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Publication number: 20130330230Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.Type: ApplicationFiled: June 6, 2013Publication date: December 12, 2013Inventors: Yochanan URI, Boaz Ran, Ariel G. Notcovich, Shay Nimri
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Patent number: 8363223Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: GrantFiled: January 12, 2012Date of Patent: January 29, 2013Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Publication number: 20120113428Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: ApplicationFiled: January 12, 2012Publication date: May 10, 2012Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Patent number: 8111400Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: GrantFiled: July 13, 2011Date of Patent: February 7, 2012Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Publication number: 20110267622Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: ApplicationFiled: July 13, 2011Publication date: November 3, 2011Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Patent number: 7999942Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: GrantFiled: August 5, 2009Date of Patent: August 16, 2011Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Publication number: 20100220330Abstract: An SPR or other optical resonance based analysis system in which, light is provided at multiple angles to a specimen and then the light modified by the specimen is processed to select only some of the light. Optionally, the processing selects light at a particular incidence angle. Optionally, the detection is by imaging of the light on a 2D imager array.Type: ApplicationFiled: May 21, 2008Publication date: September 2, 2010Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Tal Rosenzweig, Ariel G. Notcovich, Ariel Shemesh, Yochanan Uri, Michael Kanevsky, James W. Hillendahl, Barak Abraham Liraz
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Publication number: 20090296095Abstract: An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.Type: ApplicationFiled: August 5, 2009Publication date: December 3, 2009Applicant: Bio-Rad Laboratories Inc.Inventors: Boaz RAN, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Patent number: 7586616Abstract: An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.Type: GrantFiled: April 28, 2008Date of Patent: September 8, 2009Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Patent number: 7443507Abstract: An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.Type: GrantFiled: December 25, 2002Date of Patent: October 28, 2008Assignee: Bio-Rad Laboratories Inc.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson
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Publication number: 20080198384Abstract: An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.Type: ApplicationFiled: April 28, 2008Publication date: August 21, 2008Applicant: Bio-Rad Haifa Ltd.Inventors: Boaz Ran, Ariel G. Notcovich, Ariel Lipson, Shay Nimri, Stephen G. Lipson, Doron Lipson