Patents by Inventor Ariel Notcovich
Ariel Notcovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10788423Abstract: Analyte arrays such as solutes in a slab-shaped gel following electrophoresis, and particularly arrays that are in excess of 3 cm square and up to 25 cm square and higher, are imaged at distances of 5 cm or less by either forming sub-images of the entire array and stitching together the sub-images by computer-based stitching technology, or by using an array of thin-film photoresponsive elements that is coextensive with the analyte array to form a single image of the array.Type: GrantFiled: March 28, 2017Date of Patent: September 29, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: John Barich, Renee Lemaire-Adkins, David Neaz, Ariel Notcovich, Paul Patt, Ryan Short, Steven Swihart, Evan Thrush, Trey Marlowe
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Patent number: 10564098Abstract: Analyte arrays such as solutes in a slab-shaped gel following electrophoresis, and particularly arrays that are in excess of 3 cm square and up to 25 cm square and higher, are imaged at distances of 5 cm or less by either forming sub-images of the entire array and stitching together the sub-images by computer-based stitching technology, or by using an array of thin-film photoresponsive elements that is coextensive with the analyte array to form a single image of the array.Type: GrantFiled: October 17, 2013Date of Patent: February 18, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: John Barich, Renee Lemaire-Adkins, David Neaz, Ariel Notcovich, Paul Patt, Ryan Short, Steven Swihart, Evan Thrush, Trey Marlowe
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Publication number: 20170276605Abstract: Analyte arrays such as solutes in a slab-shaped gel following electrophoresis, and particularly arrays that are in excess of 3 cm square and up to 25 cm square and higher, are imaged at distances of 5 cm or less by either forming sub-images of the entire array and stitching together the sub-images by computer-based stitching technology, or by using an array of thin-film photoresponsive elements that is coextensive with the analyte array to form a single image of the array.Type: ApplicationFiled: March 28, 2017Publication date: September 28, 2017Inventors: John BARICH, Renee LEMAIRE-ADKINS, David NEAZ, Ariel NOTCOVICH, Paul PATT, Ryan SHORT, Steven SWIHART, Evan THRUSH, Trey MARLOWE
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Patent number: 9175421Abstract: Provided is a method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method includes adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at each of the microspots, there being a plurality of combinations of first binding member surface density and second binding member concentration among the plurality of microspots. Data indicative of a binding reaction between the first of microspots are then obtained and analyzed so as to obtain one or more kinetic parameters of the binding between the first and second binding members. Also provided is a system for carrying out the method. A method for localizing a molecular species at microspots on a surface, and a probe array produced by the method are also provided.Type: GrantFiled: December 21, 2011Date of Patent: November 3, 2015Assignee: Bio-Rad Haifa Ltd.Inventors: Ariel Notcovich, Alon Herschhorn, Shai Nimri, John Barich, Ariel Lipson, Ran Boaz, Doron Lipson, Yaakov Levie
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Publication number: 20140106989Abstract: Analyte arrays such as solutes in a slab-shaped gel following electrophoresis, and particularly arrays that are in excess of 3 cm square and up to 25 cm square and higher, are imaged at distances of 5 cm or less by either forming sub-images of the entire array and stitching together the sub-images by computer-based stitching technology, or by using an array of thin-film photoresponsive elements that is coextensive with the analyte array to form a single image of the array.Type: ApplicationFiled: October 17, 2013Publication date: April 17, 2014Applicant: Bio-Rad Laboratories, Inc., LSG - LSD DivisionInventors: John Barich, Renee Lemaire-Adkins, David Neaz, Ariel Notcovich, Paul Patt, Ryan Short, Steven Swihart, Evan Thrush
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Publication number: 20120129723Abstract: Provided is a method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method includes adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at each of the microspots, there being a plurality of combinations of first binding member surface density and second binding member concentration among the plurality of microspots. Data indicative of a binding reaction between the first of microspots are then obtained and analyzed so as to obtain one or more kinetic parameters of the binding between the first and second binding members. Also provided is a system for carrying out the method. A method for localizing a molecular species at microspots on a surface, and a probe array produced by the method are also provided.Type: ApplicationFiled: December 21, 2011Publication date: May 24, 2012Applicant: BIO-RAD HAIFA LTD.Inventors: Ariel NOTCOVICH, Alon HERSCHHORN, Shai NIMRI, John BARICH, Ariel LIPSON, Ran BOAZ, Doron LIPSON, Yaakov LEVIE
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Patent number: 8105845Abstract: A method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method comprises adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at each of the microspots, there being a plurality of combinations of first binding member surface density and second binding member concentration among the plurality of microspots. Data indicative of a binding reaction between the first of microspots are then obtained and analyzed so as to obtain one or more kinetic parameters of the binding between the first and second binding members. The invention also provides a system for carrying out the method. A method for localizing a molecular species at microspots on a surface, and a probe array produced by the method are also provided.Type: GrantFiled: November 14, 2004Date of Patent: January 31, 2012Assignee: Bio-Rad Haifa Ltd.Inventors: Ariel Notcovich, Alon Herschhorn, Shai Nimri, John Barich, Ariel Lipson, Ran Boaz, Doron Lipson, Yaakov Levie
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Publication number: 20070087348Abstract: A method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method comprises adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at each of the microspots, there being a plurality of combinations of first binding member surface density and second binding member concentration among the plurality of microspots. Data indicative of a binding reaction between the first of microspots are then obtained and analyzed so as to obtain one or more kinetic parameters of the binding between the first and second binding members. The invention also provides a system for carrying out the method. A method for localizing a molecular species at microspots on a surface, and a probe array produced by the method are also provided.Type: ApplicationFiled: November 14, 2004Publication date: April 19, 2007Inventors: Ariel Notcovich, Alon Herschhorn, Shai Nimri, John Barich, Ran Boaz, Doron Lipson, Yaakov Levie
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Publication number: 20060072113Abstract: An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.Type: ApplicationFiled: December 25, 2002Publication date: April 6, 2006Inventors: Boaz Ran, Ariel Notcovich, Ariel Lipson, Shay Nimri, Stephan Lipson, Doron Lipson
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Patent number: 6970249Abstract: A device for measuring simultaneously the phase at each point of an image formed by light reflected from a sample in which the phase has been modified by plasma resonance in a thin conducting layer, the device comprising a thick transparent substrate (10) on which a thin layer of conducting material is deposited (13); a light source (1); an interferometer; an imaging means (9); and a processing means.Type: GrantFiled: September 12, 2000Date of Patent: November 29, 2005Assignee: Proteoptics, Ltd.Inventors: Stephen Lipson, Ariel Notcovich