Abstract: The present application provides humanized antibodies and antigen binding fragments thereof that bind to human poliovirus (PVR). The antibodies are useful in the treatment of tumors or cancers. The present application also provides a method of treating a cancer in an individual afflicted with a cancer comprising administering to the individual a therapeutically effective amount of chimeric antigen receptor (CAR) NK or T cells.

Abstract: The present invention provides humanized antibodies and antigen binding fragments thereof that bind to human poliovirus (PVR). The antibodies are useful in the treatment of tumors or cancers.

Abstract: Described herein are anti-FLT3 agonistic antibodies. Such agonistic antibodies are useful for the expansion of dendritic cells and the treatment of cancer.

Abstract: Described herein in aspects is a humanized anti-class II MHC antibody, wherein the humanized antibody binds to class II MHC with similar or increased affinity and/or specificity as compared with a non-humanized anti-MHC class II antibody that specifically binds to a shared epitope on most or all HLA-DR molecules. Related methods and uses are also described.

Abstract: The present invention is directed to anti-activin antibodies, compositions comprising the same, and methods of using such antibodies and compositions for the prevention, diagnosis and treatment of a disease or disorder, such as, e.g., cancer, bone disease, cachexia, fibrotic disease, immune disorders, muscle atrophy, neurological diseases, renal diseases, reproductive diseases, and sarcopenia.

Abstract: The disclosure provides compositions and methods comprising at least one TGF-0 inhibitor and at least one Activin inhibitor for use in methods of treating CAF-enriched cancers and/or fibrotic disease.

Abstract: A self-assembled polypeptide complex comprises: (a) one or more fusion proteins comprising a nanocage monomer or subunit thereof linked to an Fc polypeptide, and (b) one or more fusion proteins comprising a nanocage monomer or subunit thereof linked to a SARS-COV-2 binding moiety; wherein a plurality of the fusion proteins self-assemble to form a nanocage.

Abstract: A fusion protein comprises a nanocage monomer or subunit thereof linked to an Fc polypeptide, wherein the Fc polypeptide comprises an IgG4 Fc chain with a mutation at one or more of positions 228, 234, 235, 237, and 238, according to EU numbering, and wherein a plurality of the fusion proteins self-assemble to form a nanocage.

Abstract: Systems and methods that receive as input microscopy images, extract features, and apply layers of processing units to compute one or more sets of cellular phenotype features, particularly antibodies, corresponding to cellular densities and/or fluorescence measured under different conditions. The system is a machine learning architecture having, in one aspect, a deep neural network, typically a convolutional neural network. The deep neural network can be trained and tested directly on raw microscopy images. The system computes class specific feature maps for every phenotype variable using a deep neural network. The system produces predictions for one or more reference antibody variables based on microscopy images within populations of cells.

Abstract: Disclosed herein are antibodies that specifically bind and inhibit the action of the IL-6 family member LIF that are useful in the treatment of cancer. Also disclosed herein are uses of said antibodies for the treatment of cancer.

Abstract: Described herein are methods of treating cancer comprising administering to the individual (a) a PD-1 axis inhibitor; and (b) an inhibitor of periostin.

Abstract: The present invention provides humanized antibodies and antigen binding fragments thereof that bind to human poliovirus (PVR). The antibodies are useful in the treatment of tumors or cancers.

Abstract: Described herein are anti-FLT3 agonistic antibodies. Such agonistic antibodies are useful for the expansion of dendritic cells and the treatment of cancer.

Abstract: Described herein are antibodies that block the function of periostin. Also described herein are their uses in treating cancer and modifying tumor immune properties.

Abstract: Described herein are assays useful for the quantitation of total LIF from biological samples.