Patents by Inventor Arif JETHA

Arif JETHA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250059267
    Abstract: The disclosure provides compositions and methods comprising at least one TGF-0 inhibitor and at least one Activin inhibitor for use in methods of treating CAF-enriched cancers and/or fibrotic disease.
    Type: Application
    Filed: May 13, 2022
    Publication date: February 20, 2025
    Inventors: Sam COOPER, Allison NIXON, Max LONDON, Elizabeth KOCH, Arif JETHA, Christopher HARVEY, Michael BRISKIN
  • Publication number: 20250011397
    Abstract: A self-assembled polypeptide complex comprises: (a) one or more fusion proteins comprising a nanocage monomer or subunit thereof linked to an Fc polypeptide, and (b) one or more fusion proteins comprising a nanocage monomer or subunit thereof linked to a SARS-COV-2 binding moiety; wherein a plurality of the fusion proteins self-assemble to form a nanocage.
    Type: Application
    Filed: October 14, 2022
    Publication date: January 9, 2025
    Inventors: Jean-Philippe Julien, Arif Jetha, Clare Burn Aschner, Krithika Muthuraman
  • Publication number: 20250002564
    Abstract: A fusion protein comprises a nanocage monomer or subunit thereof linked to an Fc polypeptide, wherein the Fc polypeptide comprises an IgG4 Fc chain with a mutation at one or more of positions 228, 234, 235, 237, and 238, according to EU numbering, and wherein a plurality of the fusion proteins self-assemble to form a nanocage.
    Type: Application
    Filed: October 14, 2022
    Publication date: January 2, 2025
    Inventors: Jean-Philippe Julien, Arif Jetha, Clare Burn Aschner, Krithika Muthuraman
  • Publication number: 20230170050
    Abstract: Systems and methods that receive as input microscopy images, extract features, and apply layers of processing units to compute one or more sets of cellular phenotype features, particularly antibodies, corresponding to cellular densities and/or fluorescence measured under different conditions. The system is a machine learning architecture having, in one aspect, a deep neural network, typically a convolutional neural network. The deep neural network can be trained and tested directly on raw microscopy images. The system computes class specific feature maps for every phenotype variable using a deep neural network. The system produces predictions for one or more reference antibody variables based on microscopy images within populations of cells.
    Type: Application
    Filed: April 16, 2021
    Publication date: June 1, 2023
    Inventors: Sam COOPER, Oren KRAUS, Max LONDON, Grant WATSON, Allison NIXON, Elizabeth KOCH, Ètienne DUMOULIN, Arif JETHA
  • Publication number: 20230050773
    Abstract: Disclosed herein are antibodies that specifically bind and inhibit the action of the IL-6 family member LIF that are useful in the treatment of cancer. Also disclosed herein are uses of said antibodies for the treatment of cancer.
    Type: Application
    Filed: December 3, 2020
    Publication date: February 16, 2023
    Inventors: Arif JETHA, Johan FRANSSON
  • Publication number: 20230030597
    Abstract: Described herein are methods of treating cancer comprising administering to the individual (a) a PD-1 axis inhibitor; and (b) an inhibitor of periostin.
    Type: Application
    Filed: August 27, 2020
    Publication date: February 2, 2023
    Inventors: Arif JETHA, Johan FRANSSON, AJ Robert MCGRAY, Joanne HULME
  • Publication number: 20220372161
    Abstract: The present invention provides humanized antibodies and antigen binding fragments thereof that bind to human poliovirus (PVR). The antibodies are useful in the treatment of tumors or cancers.
    Type: Application
    Filed: October 7, 2020
    Publication date: November 24, 2022
    Applicant: NECTIN THERAPEUTICS LTD.
    Inventors: Philipp ALBERTS, Arif JETHA, Johan FRANSSON, Yazen JMEIAN, Joanne HULME, Pinchas TSUKERMAN
  • Publication number: 20220025055
    Abstract: Described herein are anti-FLT3 agonistic antibodies. Such agonistic antibodies are useful for the expansion of dendritic cells and the treatment of cancer.
    Type: Application
    Filed: December 17, 2019
    Publication date: January 27, 2022
    Inventors: Arif JETHA, Phil GOBEIL, Melissa BEILSCHMIDT, Dorothea MAETZEL, Johan FRANSSON
  • Publication number: 20220010003
    Abstract: Described herein are antibodies that block the function of periostin. Also described herein are their uses in treating cancer and modifying tumor immune properties.
    Type: Application
    Filed: December 13, 2019
    Publication date: January 13, 2022
    Inventors: Arif JETHA, Johan FRANSSON, AJ Robert MCGRAY, Joanne HULME
  • Publication number: 20210190798
    Abstract: Described herein are assays useful for the quantitation of total LIF from biological samples.
    Type: Application
    Filed: June 17, 2019
    Publication date: June 24, 2021
    Inventors: Joan SEOANE SUAREZ, Judit ANIDO FOLGUEIRA, Peter Edward BAYLISS, Patricia Anne GIBLIN, Johan FRANSSON, Arif JETHA