Abstract: Systems and methods for a metadata driven microservice including: receiving data associated with a complaint; classifying the data based on a complaint type; retrieving, from a database of text elements, a set of text elements including metadata comprising display rules associated with a user interface, a set of text elements associated with the complaint type; providing a first user interface arranged based on the display rules comprising a first text element of the set of text elements and one or more input fields; receiving in the one or more input fields an input; and providing an updated user interface comprising a second text element of the set of text elements, the second text element arranged based on the display rules of the metadata.

Abstract: Methods are disclosed for inhibiting a HIV infection in a subject. These methods include administering to the subject an effective amount of a recombinant gp120 protein comprising a deletion of HIV-1 Envelope residues 137-152 according to the HXBc2 numbering system, or a nucleic acid molecule encoding the recombinant gp120 protein, wherein the recombinant gp120 protein elicits an immune response to HIV-1. The methods also include administering to the subject an effective amount of a SAMT-247 microbicide.

Abstract: A packaging system for shipping temperature-sensitive payloads to an end-user which is reconfigurable for optional easy, efficient and cost-effective empty return shipping by the end-user.

Abstract: A container may include a storage volume configured to store a payload. A thermal insulation layer may surround the storage volume. A thermoregulation layer may surround the thermal insulation layer. There may be activation of a chemical reaction in the thermoregulation layer. The thermal insulation layer may have R-value per inch configured to expose the payload to a desired temperature to ensure viability of the payload and dampen a temperature spike of the chemical reaction. A system of containers may include a system storage volume with N containers in the system storage volume, wherein N is a whole number of 2 or more. A method of making an insulated container may include preparing an outer skin barrier layer, stacking a thermoregulation layer on the outer skin barrier layer, stacking a thermal insulation layer on the thermoregulation layer, and stacking an inner skin barrier layer on the thermal insulation layer.

Abstract: A system and method implemented on a computing device which tracks a condition of a payload and a container conveying the payload in shipment by a tracking module which receives signals from one or more sensors. The monitoring data is transmitted to a remote server which communicates in real-time, calculates a current condition or state of the payload and container, and which predicts one or more future conditions or states of the payload and container based on an expected environmental, operational and handling conditions. The predicted future condition is compared to estimated time of shipment completion and one or more prescribed condition thresholds corresponding to the type of the payload, container type and the shipping route. Responsive to predicting an impending violation of a payload handling condition, an intervention decision is made, and one or more notifications with optional digital preventive action procedures are transmitted to corresponding users.

Abstract: A container may include a storage volume configured to store a payload. A thermal insulation layer may surround the storage volume. A thermoregulation layer may surround the thermal insulation layer. There may be activation of a chemical reaction in the thermoregulation layer. The thermal insulation layer may have R-value per inch configured to expose the payload to a desired temperature to ensure viability of the payload and dampen a temperature spike of the chemical reaction. A system of containers may include a system storage volume with N containers in the system storage volume, wherein N is a whole number of 2 or more. A method of making an insulated container may include preparing an outer skin barrier layer, stacking a thermoregulation layer on the outer skin barrier layer, stacking a thermal insulation layer on the thermoregulation layer, and stacking an inner skin barrier layer on the thermal insulation layer.

Abstract: Embodiments of the present invention provide tightly coupled off-die memory along with an interface bus and smart buffer logic so as to efficiently perform certain frequent or repetitive operations off of a core logic. Embodiments of the present invention relieve the core logic from performing certain repetitive or frequent memory accesses and other operations so as to allow such core logic to perform other more general or varied operations. In this way, the universal interface bus, smart buffer logic, and off-die memory are specially configured to perform certain select frequent and repetitive operations while the core logic may configured to perform other operations so as to provide an improved configuration with increased computational capability and reduced power budget.

Abstract: Status of a payload and a shipping container is tracked and monitored by a tracking module which receives at least one signal from one or more sensors; determines a rate of change over time for the signal(s) and sensor(s); compares, in real-time, memory-stored rate-of-change thresholds corresponding to a payload type to the determined rate(s) of change; and, responsive to the comparison indicating a current or impending violation of a payload handling condition, powers up a wireless communications interface, communicates a digital report to a remote computing system, and powers down the wireless communications interface upon completion of the communicating of the report, while continuing to monitor the sensor(s).

Abstract: Embodiments of the present invention provide tightly coupled off-die memory along with an interface bus and smart buffer logic so as to efficiently perform certain frequent or repetitive operations off of a core logic. Embodiments of the present invention relieve the core logic from performing certain repetitive or frequent memory accesses and other operations so as to allow such core logic to perform other more general or varied operations. In this way, the universal interface bus, smart buffer logic, and off-die memory are specially configured to perform certain select frequent and repetitive operations while the core logic may configured to perform other operations so as to provide an improved configuration with increased computational capability and reduced power budget.

Abstract: A fluid routing device includes a fluid inlet, first vertical channels, a horizontal channel, a second vertical channel, and a fluid outlet. The first vertical channels are open to the fluid inlet. The horizontal channel is open to each of the first vertical channels. The first vertical channels are oriented to provide fluid coolant from the fluid inlet vertically down to the horizontal channel. The horizontal channel is open on one side such that fluid coolant in the horizontal channel directly contacts an apparatus attached to a bottom of the fluid routing device. The second vertical channel is open to the horizontal channel. The second vertical channel is oriented to provide fluid coolant vertically up away from the horizontal channel. The fluid outlet is open to the second vertical channel such that fluid coolant from the second vertical channel exits the fluid routing device through the fluid outlet.

Abstract: A storage and shipping container system for a set of specific related components, such as multiple blood products, which conveys the components in pre-determined ratios, having a thermally-insulated main container with a plurality of internal chambers, and at least one attached auxiliary container which is thermally-insulated. Optionally, the system is provided with wheels and a collapsible handle for easy movement of one system, and configured for stacking of multiple similar systems for bulk transportation.

Abstract: Status of a payload and a shipping container is tracked and monitored by a tracking module which receives at least one signal from one or more sensors; determines a rate of change over time for the signal(s) and sensor(s); compares, in real-time, memory-stored rate-of-change thresholds corresponding to a payload type to the determined rate(s) of change; and, responsive to the comparison indicating a current or impending violation of a payload handling condition, powers up a wireless communications interface, communicates a digital report to a remote computing system, and powers down the wireless communications interface upon completion of the communicating of the report, while continuing to monitor the sensor(s).

Abstract: A storage and shipping container system for a set of specific related components, such as multiple blood products, which conveys the components in pre-determined ratios, having a thermally-insulated main container with a plurality of internal chambers, and at least one attached auxiliary container which is thermally-insulated. Optionally, the system is provided with wheels and a collapsible handle for easy movement of one system, and configured for stacking of multiple similar systems for bulk transportation.

Abstract: A shipping and storage system which has an access panel with an optional open/close status sensor, and a payload carrier with an affixed sensor connected to a tracking module that monitors the environment of the payload carrier, such as temperature, against a pre-determined threshold for compliance with pre-determined handling and storage requirements for a specific payload type, such as a specific blood product. When a violation is detected by the tracking module, a user alert or user interface is activated. Advanced features optionally include a plurality of pre-determined threshold sets for a plurality of specific payload types, a tamper detection function based on the access panel status and optional weight changes in the payload carrier, and wireless connectivity to allow mobile device and cloud-based enhanced management functions.

Abstract: A fluid routing device includes a fluid inlet, first vertical channels, a horizontal channel, a second vertical channel, and a fluid outlet. The first vertical channels are open to the fluid inlet. The horizontal channel is open to each of the first vertical channels. The first vertical channels are oriented to provide fluid coolant from the fluid inlet vertically down to the horizontal channel. The horizontal channel is open on one side such that fluid coolant in the horizontal channel directly contacts an apparatus attached to a bottom of the fluid routing device. The second vertical channel is open to the horizontal channel. The second vertical channel is oriented to provide fluid coolant vertically up away from the horizontal channel. The fluid outlet is open to the second vertical channel such that fluid coolant from the second vertical channel exits the fluid routing device through the fluid outlet.