Patents by Inventor Arihiro Kanada
Arihiro Kanada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7385029Abstract: The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.Type: GrantFiled: July 14, 2005Date of Patent: June 10, 2008Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Koichi Miyazaki, Katsuyuki Keino, Arihiro Kanada, Nobuyoshi Minami
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Patent number: 7087624Abstract: Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)-(A)n-Y, —CH2—CH(R4)-(A)n-Y, —CO-B1-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group.Type: GrantFiled: October 27, 2003Date of Patent: August 8, 2006Assignee: Teikoju Hormone Mfg. Co., Ltd.Inventors: Nobuyoshi Minami, Michitaka Sato, Koichi Hasumi, Norio Yamamoto, Katsuyuki Keino, Teruaki Matsui, Arihiro Kanada, Shuji Ohta, Takahisa Saito, Shuichiro Sato, Akira Asagarasu, Satoshi Doi, Motohiro Kobayashi, Jun Sato, Hajime Asano
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Patent number: 7008928Abstract: The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.Type: GrantFiled: September 19, 2002Date of Patent: March 7, 2006Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Koichi Miyazaki, Katsuyuki Keino, Arihiro Kanada, Nobuyoshi Minami
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Publication number: 20050267041Abstract: The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S, 2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.Type: ApplicationFiled: July 14, 2005Publication date: December 1, 2005Inventors: Koichi Miyazaki, Katsuyuki Keino, Arihiro Kanada, Nobuyoshi Minami
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Publication number: 20040254343Abstract: The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.Type: ApplicationFiled: March 22, 2004Publication date: December 16, 2004Inventors: Koichi Miyazaki, Katsuyuki Keino, Arihiro Kanada, Nobuyoshi Minami
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Patent number: 6750315Abstract: The present invention is envisioned to improve sliding characteristics of polyether aromatic ketone resins and to provide their molded articles which are themselves resistant to damage and abrasion, cause no such damage or abrasion to their partner parts and can be easily molded. Thus, the present invention pertains to a polyether aromatic ketone resin composition comprising a polyether aromatic ketone resin and a high-hardness filler having a Mohs hardness of 6 or higher, the content of said filler being 1 to 100 parts by weight per 100 parts by weight of said ketone resin, and furthermore to a film or sheet made of the resin composition. The high-hardness filler having a Mohs hardness of 6 or higher is preferably particulate or spherical in particle shape. Also, the maximal particle size of said high-hardness filler is preferably not larger than 100 &mgr;m.Type: GrantFiled: October 4, 2002Date of Patent: June 15, 2004Assignee: Sumitomo Bakelite Company LimitedInventor: Arihiro Kanada
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Publication number: 20040087628Abstract: Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)-(A)n —Y, —CH2 —CH(R4)-(A)n—Y, —CO—B1-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.Type: ApplicationFiled: October 27, 2003Publication date: May 6, 2004Inventors: Nobuyoshi Minami, Michitaka Sato, Koichi Hasumi, Norio Yamamoto, Katsuyuki Keino, Teruaki Matsui, Arihiro Kanada, Shuji Ohta, Takahisa Saito, Shuichiro Sato, Akira Asagarasu, Satoshi Doi, Motohiro Kobayashi, Jun Sato, Hajime Asano
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Patent number: 6667325Abstract: Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)—(A)n—Y, —CH2—CH(R4)—(A)n—Y, —CO—B1—A—Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.Type: GrantFiled: December 3, 2001Date of Patent: December 23, 2003Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Nobuyoshi Minami, Michitaka Sato, Koichi Hasumi, Norio Yamamoto, Katsuyuki Keino, Teruaki Matsui, Arihiro Kanada, Shuji Ohta, Takahisa Saito, Shuichiro Sato, Akira Asagarasu, Satoshi Doi, Motohiro Kobayashi, Jun Sato, Hajime Asano
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Publication number: 20030105269Abstract: The present invention is envisioned to improve sliding characteristics of polyether aromatic ketone resins and to provide their molded articles which are themselves resistant to damage and abrasion, cause no such damage or abrasion to their partner parts and can be easily molded. Thus, the present invention pertains to a polyether aromatic ketone resin composition comprising a polyether aromatic ketone resin and a high-hardness filler having a Mohs hardness of 6 or higher, the content of said filler being 1 to 100 parts by weight per 100 parts by weight of said ketone resin, and furthermore to a film or sheet made of the resin composition. The high-hardness filler having a Mohs hardness of 6 or higher is preferably particulate or spherical in particle shape. Also, the maximal particle size of said high-hardness filler is preferably not larger than 100 &mgr;m.Type: ApplicationFiled: October 4, 2002Publication date: June 5, 2003Inventor: Arihiro Kanada
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Patent number: 6511997Abstract: Aminopyrazole derivatives represented by formula (I), or salts thereof, wherein X1 and X2 are each a hydrogen atom or a halogen atom, or X1 and X2 may be united together to form a lower alkylenedioxy group, Q is a pyridyl group or a quinolyl group, R1 is a hydrogen atom, a substituted or unsubstituted lower alkyl or aryl group, R2 is a hydrogen atom, a lower alkyl group, or an aralkyl group, and R3 represents a hydrogen atom, an organic sulfonyl group, or —C(═Y)—R4 in which R4 is a hydrogen atom or an organic residue and Y is an oxygen or sulfur atom, provided that, when R3 is a hydrogen atom, R1 is a group other than a hydrogen atom and R2 is a hydrogen atom. These amimopyrazole derivatives or their salts have excellent p38MAP kinase inhibiting activities and are hence useful in the prevention or treatment of diseases associated with tumor necrosis sis factor &agr;, interleukin 1, interleukin 6 or cyclooxygenase II.Type: GrantFiled: June 22, 2001Date of Patent: January 28, 2003Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Nobuyoshi Minami, Michitaka Sato, Koichi Hasumi, Norio Yamamoto, Katsuyuki Keino, Teruaki Matsui, Arihiro Kanada, Shuji Ohta, Takahisa Saito, Shuichiro Sato, Akira Asagarasu, Satoshi Doi, Motohiro Kobayashi, Jun Sato, Hajime Asano