Patents by Inventor Aristeidis G. Telonis

Aristeidis G. Telonis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Leveraging the presence or absence of miRNA isoforms for recommending therapy in cancer patients
    Patent number: 11905563
    Abstract: A method of identifying a subject in need of therapeutic intervention to treat a disease or condi-tion or disease recurrence or disease progression comprising, isolating isomiRs or miRNAs from a sample obtained from the subject; and characterizing the isomiRs or miRNAs and their presence or absence in the sample to identify a signature, wherein when the signature is indicative of a di-agnosis of the disease then treatment of the subject is recommended.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: February 20, 2024
    Assignee: Thomas Jefferson University
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • Systems-level Analysis of 32 TCGA Cancers Reveals Disease-Dependent tRNA Fragmentation Patterns and Very Selective Associations with Messenger RNAs and Repeat Elements
    Publication number: 20230282308
    Abstract: Methods of treating a disease by leveraging positive and negative correlations between tRNA-derived fragments (tRF) and messenger RNA (mRNA) wherein said correlations can be used to establish a level of granularity that is specific to a disease of interest wherein said disease-specific positive and negative correlations can allow a level of therapeutic intervention that will be unprecedented because it will have been informed by three dimensions: at least one mRNA of interest; at least one tRF that are positively/negatively correlated with it; and, the identity of the disease in which one wishes to modulate the abundance of the at least one mRNA of interest.
    Type: Application
    Filed: December 15, 2022
    Publication date: September 7, 2023
    Applicant: Thomas Jefferson University
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • Systems-level analysis of 32 TCGA cancers reveals disease-dependent tRNA fragmentation patterns and very selective associations with messenger RNAs and repeat elements
    Patent number: 11715549
    Abstract: Methods of treating a disease by leveraging positive and negative correlations between tRNA-derived fragments (tRF) and messenger RNA (mRNA) wherein said correlations can be used to establish a level of granularity that is specific to a disease of interest wherein said disease-specific positive and negative correlations can allow a level of therapeutic intervention that will be unprecedented because it will have been informed by three dimensions: at least one mRNA of interest; at least one tRF that are positively/negatively correlated with it; and, the identity of the disease in which one wishes to modulate the abundance of the at least one mRNA of interest.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: August 1, 2023
    Assignee: THOMAS JEFFERSON UNIVERSITY
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • SYSTEMS-LEVEL ANALYSIS OF 32 TCGA CANCERS REVEALS DISEASE-DEPENDENT TRNA FRAGMENTATION PATTERNS AND VERY SELECTIVE ASSOCIATIONS WITH MESSENGER RNAS AND REPEAT ELEMENTS
    Publication number: 20200202976
    Abstract: Methods of treating a disease by leveraging positive and negative correlations between tRNA-derived fragments (tRF) and messenger RNA (mRNA) wherein said correlations can be used to establish a level of granularity that is specific to a disease of interest wherein said disease-specific positive and negative correlations can allow a level of therapeutic intervention that will be unprecedented because it will have been informed by three dimensions: at least one mRNA of interest; at least one tRF that are positively/negatively correlated with it; and, the identity of the disease in which one wishes to modulate the abundance of the at least one mRNA of interest.
    Type: Application
    Filed: May 1, 2018
    Publication date: June 25, 2020
    Applicant: Thomas Jefferson University
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • LEVERAGING THE PRESENCE OR ABSENCE OF MIRNA ISOFORMS FOR RECOMMENDING THERAPY IN CANCER PATIENTS
    Publication number: 20190249262
    Abstract: A method of identifying a subject in need of therapeutic intervention to treat a disease or condi-tion or disease recurrence or disease progression comprising, isolating isomiRs or miRNAs from a sample obtained from the subject; and characterizing the isomiRs or miRNAs and their presence or absence in the sample to identify a signature, wherein when the signature is indicative of a di-agnosis of the disease then treatment of the subject is recommended.
    Type: Application
    Filed: October 23, 2017
    Publication date: August 15, 2019
    Applicant: THOMAS JEFFERSON UNIVERSITY
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis