Patents by Inventor Arja M. Kalapudas

Arja M. Kalapudas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective aromatase inhibiting 4(5)-imidazoles
    Patent number: 5559141
    Abstract: New 4(5)-imidazole derivatives of formula (Ia) and (Ib) wherein one of R.sub.1 and R.sub.2 is CN and the other one is H, CH.sub.3, OCH.sub.3, NO.sub.2, NH.sub.2, CN, CF.sub.3, CHF.sub.2, CH.sub.2 F or halogen; R' is H or (II) where R.sub.3 is H, CH.sub.3 or halogen; R.sub.4 is H and R.sub.5 is H or R.sub.4 and R.sub.5 together form a bond, n is 1 or 2 and y is 0 to 2, their stereoisomers and their non-toxic pharmaceutically acceptable acid addition salts exhibit selective aromatase inhibiting properties, compared with their desmolase inhibiting properties. The compounds of the invention are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer or benign prostatic hyperplasia (BPH).
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: September 24, 1996
    Assignee: Orion-yhtyma Oy
    Inventors: Arto J. Karjalainen, Marja-Liisa Sodervall, Arja M. Kalapudas, Reino O. Pelkonen, Aire M. Laine, Risto A. Lammintausta, Jarmo S. Salonen
  • Aromatase inhibiting 4(5)-imidazoles
    Patent number: 5439928
    Abstract: Novel 4(5)-imidazole derivatives of specified formula and their non-toxic salts possess selective aromatase inhibiting properties, which are valuable in the treatment of estrogen dependent diseases e.g. breast cancer.
    Type: Grant
    Filed: May 19, 1993
    Date of Patent: August 8, 1995
    Assignee: Orion-yhtyma Oy
    Inventors: Arto J. Karjalainen, Reino O. Pelkonen, Marja-Liisa Sodervall, Matti A. Lahde, Risto A. S. Lammintausta, Arja L. Karjalainen, Arja M. Kalapudas