Abstract: The disclosure presents an apparatus and method for measuring viscosity of a lubricating oil. The apparatus has a piezo-resistive cantilever sensor for sensing a first oil viscosity parameter. The sensor has a cantilever having a pressure receiving portion for receiving pressure exerted by the lubricating oil as the lubricating oil comes into contact with the pressure receiving portion. The cantilever also has first and second resistive portions in electrical communication with a first lead and a second lead, respectively, which are in electrical communication with an electrical circuit amplification element, for creating an output signal indicative of a change in the resistive characteristics of the first and second resistive portions of the cantilever as the lubricating oil comes into contact with the pressure receiving portion. The output signal can be used for determining oil viscosity.

Abstract: An apparatus and method for using nanostructures, such as nanopores, nanofibers, nanowells, or nanocones as carriers for drugs, biomarkers and/or biomolecules. The apparatus and method for use on implant surfaces to retain and release drugs, biomarkers and/or biomolecules on command by an external stimulus.

Abstract: The disclosure presents an apparatus and method for measuring viscosity of a lubricating oil. The apparatus has a piezo-resistive cantilever sensor for sensing a first oil viscosity parameter. The sensor has a cantilever having a pressure receiving portion for receiving pressure exerted by the lubricating oil as the lubricating oil comes into contact with the pressure receiving portion. The cantilever also has first and second resistive portions in electrical communication with a first lead and a second lead, respectively, which are in electrical communication with an electrical circuit amplification element, for creating an output signal indicative of a change in the resistive characteristics of the first and second resistive portions of the cantilever as the lubricating oil comes into contact with the pressure receiving portion. The output signal can be used for determining oil viscosity.

Abstract: This invention provides a sensor to measure physical and/or chemical properties of viscous fluids. The sensor is based on microfabricated piezoresistive cantilevers. Deflection of these cantilevers is read out using, e.g., a wheatstone bridge to amplify and convert the deflection into a voltage output. The cantilevers and/or tips attached thereto, can be chemically or physically modified using reagents specific to interact with analytes to be detected in the fluid. The cantilevers can be integrated in a microfluidic system for easy fluid handling and the ability to manage small quantities of fluids.

Abstract: The present invention relates to a novel channel structure of human amyloid beta protein (AbP) in lipid membranes and a rapid, quantitative and specific assay for screening test compounds, such as drugs, ligands (natural or synthetic), proteins, peptides and small organic molecules for their ability to bind and block the membrane AbP channels. The invention further relates to screening and identifying therapeutically relevant compounds for treating Alzheimer's disease and other disorders.

Abstract: This invention provides a device and methods for the rapid detection and/or diagnosis and/or characterization of one or more allergies (e.g., causes IgE mediated allergic reaction (immediate hypersensitvity) in a mammal (e.g., a human or a non-human mammal). In certain embodiments, the device comprises a microcantilever array where different cantilevers comprising the array bear different antigens. Binding of IgE to the antigen on a cantilever causes bending of the cantilever which can be readily detected.

Abstract: The present invention relates to the positioning of nanoparticles on surfaces, and in particular to a method for first positioning nucleic acid polymers onto surface defects on a surface in order to utilise the principle of base pairing for achieving a site specific organisation of particles and macromolecules. The inventive method comprises the positioning of corresponding base pairs in the form of primers on the particles or macromolecules to be positioned, and a high resolution, preferably a resolution of 1-50 nm can be achieved.

Abstract: A method of arraying nanoparticles and macromolecules on surfaces, wherein a pattern of surface defects are created on a surface, the form, appearance and mapping out of the surface defects being adapted to those nanoparticles and/or macromolecules which are to be arrayed.