Patents by Inventor Arjanne Overeem

Arjanne Overeem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR MAKING SUGAMMADEX
    Publication number: 20210095052
    Abstract: The invention relates to a process for making the pharmaceutical product Sugammadex. The process comprises reacting a 6-per-deoxy-6-per-halo-?-cyclodextrin with 3-mercaptopropionic acid in the presence of a sodium base and DMSO to form Sugammadex.
    Type: Application
    Filed: December 15, 2020
    Publication date: April 1, 2021
    Inventor: Arjanne OVEREEM
  • Process for making Sugammadex
    Patent number: 10894839
    Abstract: The invention deals with a novel process for making the pharmaceutically useful product Sugammadex of formula (1)
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: January 19, 2021
    Assignee: Synthon B.V.
    Inventor: Arjanne Overeem
  • PROCESS FOR MAKING SUGAMMADEX
    Publication number: 20190185589
    Abstract: The invention deals with a novel process for making the pharmaceutically useful product Sugammadex of formula (1)
    Type: Application
    Filed: June 22, 2017
    Publication date: June 20, 2019
    Applicant: Synthon B.V.
    Inventor: Arjanne OVEREEM
  • Process for making montelukast and intermediates therefor
    Patent number: 7829716
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (20) is provided.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: November 9, 2010
    Assignee: Synthon Pharmaceuticals, Inc.
    Inventors: Arjanne Overeem, Reinerus G. Gieling, Jie Zhu, Lambertus Thijs
  • Process for making montelukast and intermediates therefor
    Patent number: 7786138
    Abstract: A compound of the following formula wherein R? is a straight or branched C1-C4 alkyl group is useful in processes associated with the synthesis of montelukast and its salts.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: August 31, 2010
    Assignee: Synthon BV
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR
    Publication number: 20100099879
    Abstract: The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula and salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.
    Type: Application
    Filed: October 9, 2009
    Publication date: April 22, 2010
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • Process for making montelukast and intermediates therefor
    Patent number: 7601741
    Abstract: The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula and salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: October 13, 2009
    Assignee: Synthon BV
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • Solid-state montelukast
    Patent number: 7553853
    Abstract: A solid form of a compound of formula 1: is provided. The compound of formula 1 can be obtained in solid state by precipitation from a solution containing the same. The compound is useful as leukotriene antagonist and can be formulated into a pharmaceutical composition that also includes a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: June 30, 2009
    Assignee: Synthon BV
    Inventors: Arjanne Overeem, Dennie J. M. van den Heuvel
  • Process for making aminoalkylphenyl carbamates and intermediates therefor
    Patent number: 7531684
    Abstract: A process for making aminoalkylphenyl carbamates, especially rivastigmine, can use less severe conditions using bis(p-nitrophenyl)carbonate (IX) as a phenol activator compound.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: May 12, 2009
    Assignee: Synthon BV
    Inventors: Henar Tejedor Vinent, Arjanne Overeem, Lambertus Thijs
  • PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR
    Publication number: 20090093636
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (11) is provided.
    Type: Application
    Filed: December 12, 2008
    Publication date: April 9, 2009
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • Process for making montelukast and intermediates therefor
    Patent number: 7501517
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (4) is provided.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: March 10, 2009
    Assignee: Synthon IP, Inc.
    Inventors: Arjanne Overeem, Reinerus G. Gieling, Jie Zhu, Lambertus Thijs
  • Process for making montelukast and intermediates therefor
    Patent number: 7476748
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (11) is provided.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: January 13, 2009
    Assignee: Synthon BV
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • POLYMORPHS OF RIVASTIGMINE HYDROGENTARTRATE
    Publication number: 20080255231
    Abstract: A crystalline rivastigmine hydrogentartrate of Form II and an amorphous rivastigmine hydrogentartrate of Form III.
    Type: Application
    Filed: March 7, 2008
    Publication date: October 16, 2008
    Inventors: Arjanne Overeem, Henar Tejedor Vinent
  • PROCESS FOR MAKING AMINOALKYLPHENYL CARBAMATES AND INTERMEDIATES THEREFOR
    Publication number: 20080154057
    Abstract: A process for making aminoalkylphenyl carbamates, especially rivastigmine, can use less severe conditions using bis(p-nitrophenyl)carbonate (IX) as a phenol activator compound.
    Type: Application
    Filed: September 28, 2007
    Publication date: June 26, 2008
    Inventors: Henar Tejedor Vinent, Arjanne Overeem, Lambertus Thijs
  • PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR
    Publication number: 20070135642
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (11) is provided.
    Type: Application
    Filed: November 20, 2006
    Publication date: June 14, 2007
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR
    Publication number: 20070135643
    Abstract: The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula and salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.
    Type: Application
    Filed: November 20, 2006
    Publication date: June 14, 2007
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR
    Publication number: 20070135480
    Abstract: A compound of the following formula wherein R? is a straight or branched C1-C4 alkyl group is useful in processes associated with the synthesis of montelukast and its salts.
    Type: Application
    Filed: November 20, 2006
    Publication date: June 14, 2007
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • Process for making montelukast and intermediates therefor
    Publication number: 20050245569
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (4) is provided.
    Type: Application
    Filed: March 17, 2005
    Publication date: November 3, 2005
    Inventors: Arjanne Overeem, Reinerus Gieling, Jie Zhu, Lambertus Thijs
  • Process for making montelukast and intermediates therefor
    Publication number: 20050245568
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (20) is provided.
    Type: Application
    Filed: March 17, 2005
    Publication date: November 3, 2005
    Inventors: Arjanne Overeem, Reinerus Gieling, Jie Zhu, Lambertus Thijs
  • Solid-state montelukast
    Publication number: 20050107426
    Abstract: A solid form of a compound of formula 1: is provided. The compound of formula 1 can be obtained in solid state by precipitation from a solution containing the same. The compound is useful as leukotriene antagonist and can be formulated into a pharmaceutical composition that also includes a pharmaceutically acceptable excipient.
    Type: Application
    Filed: October 8, 2004
    Publication date: May 19, 2005
    Inventors: Arjanne Overeem, Dennie van den Heuvel