Abstract: Systems and methods to maintain a genotype-phenotype link during the production of viral particles are described. Cells are genetically modified to include a landing pad with an integrase attachment site within the cell's genome. The landing pad provides a site within the genome for a viral vector to reliably integrate. The landing pad allows for the integration of one viral vector per cell. Viral vectors include a barcode and a sequence encoding a protein of interest, with the barcode and protein of interest being associated through sequencing before integration into landing pads within cells.