Abstract: The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.

Abstract: An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. A yeast strain engineered to metabolize arabinose through a novel pathway is also disclosed. Methods of producing ethanol include utilizing these modified yeast strains.

Abstract: A fuel injector for a secondary fuel nozzle in a gas turbine includes axially oriented air slots and a plurality of fuel injection holes disposed between the air slots. The plurality of fuel injection holes include axially oriented injection holes and radially oriented injection holes such that fuel input through the plurality of fuel injection holes is injected in both a radial direction and an axial direction to mix with air flowing through the air slots.

Abstract: A combustor assembly for a turbine engine includes a fuel nozzle located at an upstream end of the combustor assembly. The fuel nozzle includes both a fuel delivery passageway and a purge air passageway. The purge air passageway conveys a flow of purge air to cool the fuel nozzle. The combustor assembly also includes a combustion product return line that conveys a flow of combustion products from a position downstream of a combustion zone of the combustor back to the fuel nozzle. The combustion products are mixed with purge air, and the mixture is delivered into a combustion zone located just downstream of the fuel nozzle. The addition of the combustion products into the purge air reduces the amount of oxygen in mixed flow, which helps to reduce the generation of undesirable nitrogen oxide combustion byproducts. Also, the greater heat of the combustion products helps to increase the temperature of the mixture, which helps to maintain the stability of a pilot flame fed by the mixture.

Abstract: An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. Methods of producing ethanol include utilizing these modified yeast strains.

Abstract: One embodiment of the present invention provides a system that identifies network switches along a path. During operation, the system receives an address of a source node and an address of a destination node. The system maintains a set of topology information for a network. The system further simulates a data packet originated at the source node and destined for the destination node. During the simulation, the system determines whether a current-hop node performs layer-3, layer-2, or sub-layer-2 switching. The system sends a query to the current-hop node over a separate control channel to determine the status of the current-hop node and discover a next-hop node. The system then receives a reply. The system determines the next-hop node based on the reply and sets the next-hop node as the current-hop node.

Abstract: An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. Methods of producing ethanol include utilizing these modified yeast strains.

Abstract: A fuel injector for a secondary fuel nozzle in a gas turbine includes axially oriented air slots and a plurality of fuel injection holes disposed between the air slots. The plurality of fuel injection holes include axially oriented injection holes and circumferentially oriented injection holes such that fuel input through the plurality of fuel injection holes is injected in both a circumferential direction and an axial direction to mix with air flowing through the air slots.

Abstract: Network routing is effected for interconnection networks. According to an example embodiment of the present invention, an adaptive load-balanced routing approach is implemented for interconnection networks. Approximate global congestion is sensed as a function of congestion of channel queues, with routing approaches selected in accordance with the sensed congestion.

Abstract: A toroidal ring manifold for effectively dispersing premixing fuel with air in the secondary fuel nozzle of a combustor for a Dry Low NOx (DLN) gas turbine, thereby providing stable combustion with low nitrogen oxide (NOx) emissions. The toroidal ring manifold is centered around a centerbody hub of a secondary fuel nozzle assembly in a premixing volume between the nozzle centerbody hub body and a centerbody cap. The ring manifold receives fuel from the nozzle body and dispenses premix fuel from a plurality of rows of individual holes on its downstream surface into an axial airstream. The number and location of the rows, the number, size and spacing of holes in each row, and the radial position of the toroidal ring manifold within the premixing volume are optimized to promote premixing.

Abstract: The isolation of the yeast ?-factor genes is described. The promoter and signal peptide portions are isolated and joined to DNA coding for proteins heterologous to yeast in a plasmid which is used to transform yeast cells. The yeast expresses the heterologous DNA and processes and secretes the heterologous protein.

Abstract: Human insulin-like growth factor is synthesized in recombinant cell culture by host cells transformed with expression vectors bearing DNA encoding human insulin-like growth factor.