Patents by Inventor Arkadiusz Wyrzucki

Arkadiusz Wyrzucki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi-strain-reactive antibodies for therapy and diagnosis of influenza
    Patent number: 9512202
    Abstract: The invention relates to a method for isolating a polypeptide reactive to influenza A hemagglutinin, comprising the steps of preparing a library of nucleic acid sequences, wherein each member of said library is attached to a polypeptide sequence encoded thereby, selecting members of said library by contacting the members with a panning antigen, wherein the panning antigen comprises a hemagglutinin stem region polypeptide sequence, subsequently removing members unreactive to the panning antigen, and selecting a member of said library by determining its binding to at least 5 influenza A hemagglutinin subtypes of subtype group 1 and 2. The invention further relates to polypeptides, particularly antibodies, obtainable by this method, that neutralize at least five influenza A subtypes of subtype group 1 and 2, to vaccines and uses thereof.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: December 6, 2016
    Assignee: UNIVERSITY OF ZURICH
    Inventors: Lars Hangartner, Arkadiusz Wyrzucki
  • Multi-strain-reactive Antibodies for Therapy and Diagnosis of Influenza
    Publication number: 20140370032
    Abstract: The invention relates to a method for isolating a polypeptide reactive to influenza A hemagglutinin, comprising the steps of preparing a library of nucleic acid sequences, wherein each member of said library is attached to a polypeptide sequence encoded thereby, selecting members of said library by contacting the members with a panning antigen, wherein the panning antigen comprises a hemagglutinin stem region polypeptide sequence, subsequently removing members unreactive to the panning antigen, and selecting a member of said library by determining its binding to at least 5 influenza A hemagglutinin subtypes of subtype group 1 and 2. The invention further relates to polypeptides, particularly antibodies, obtainable by this method, that neutralize at least five influenza A subtypes of subtype group 1 and 2, to vaccines and uses thereof.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 18, 2014
    Applicant: UNIVERSITAT ZURICH
    Inventors: Lars Hangartner, Arkadiusz Wyrzucki