Patents by Inventor Arlene Roland

Arlene Roland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phospho-indoles as HIV inhibitors
    Patent number: 8044091
    Abstract: 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: October 25, 2011
    Assignee: Idenix Pharmaceuticals, Inc.
    Inventors: Richard Storer, Cyril Dousson, Francois-Rene Alexandre, Arlene Roland
  • Phosphadiazine HCV polymerase inhibitors IV
    Patent number: 7932240
    Abstract: Provided herein are phosphadiazine polymerase inhibitor, for example, of any of Formulas IV, IV?, I?, II?, or IVa, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: April 26, 2011
    Assignee: Idenix Pharmaceuticals, Inc.
    Inventors: Cyril Dousson, Dominique Surleraux, Jean-Laurent Paparin, Claire Pierra, Arlène Roland
  • Nucleic acid-based compounds and methods of use thereof
    Patent number: 7709449
    Abstract: The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: May 4, 2010
    Assignee: Migenix, Inc.
    Inventors: Radhakrishnan P. Iyer, Yi Jin, Arlene Roland, Wenqiang Zhou
  • PHOSPHO-INDOLES AS HIV INHIBITORS
    Publication number: 20090163444
    Abstract: 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
    Type: Application
    Filed: November 21, 2008
    Publication date: June 25, 2009
    Inventors: Richard Storer, Cyril Dousson, Francois-Rene Alexandre, Arlene Roland
  • Phospho-indoles as HIV inhibitors
    Patent number: 7534809
    Abstract: 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: May 19, 2009
    Assignee: Idenix Pharmaceuticals, Inc.
    Inventors: Richard Storer, Cyril Dousson, Francois-Rene Alexandre, Arlene Roland
  • PHOSPHADIAZINE HCV POLYMERASE INHIBITORS IV
    Publication number: 20090081158
    Abstract: Provided herein are phosphadiazine polymerase inhibitor, for example, of any of Formulas IV, IV?, I?, II?, or IVa, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
    Type: Application
    Filed: August 27, 2008
    Publication date: March 26, 2009
    Applicant: Idenix Pharmaceuticals, Inc.
    Inventors: Cyril Dousson, Dominique Surleraux, Jean-Laurent Paparin, Claire Pierra, Arlene Roland
  • PHOSPHADIAZINE HCV POLYMERASE INHIBITORS I AND II
    Publication number: 20090060866
    Abstract: Provided herein are phosphadiazine polymerase inhibitor, for example, of any of Formula I, II, III, I?, II?, I?, II?, Ia, IIa, or IIIa, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
    Type: Application
    Filed: August 27, 2008
    Publication date: March 5, 2009
    Applicant: Idenix Pharmaceuticals, Inc.
    Inventors: Cyril Dousson, Dominique Surleraux, Arlene Roland, Claire Pierra, Daniel Da Costa
  • PHOSPHADIAZINE HCV POLYMERASE INHIBITORS III AND VI
    Publication number: 20090060867
    Abstract: Provided herein are phosphadiazine polymerase inhibitor, for example, of Formula III, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
    Type: Application
    Filed: August 27, 2008
    Publication date: March 5, 2009
    Applicant: Idenix Pharmaceuticals, Inc.
    Inventors: Cyril Dousson, Dominique Surleraux, Jean-Francois Griffon, Claire Pierra, Arlene Roland, Rachid Rahali
  • Nucleic Acid-Based Compounds and Methods of Use Thereof
    Publication number: 20070270359
    Abstract: The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units.
    Type: Application
    Filed: July 10, 2007
    Publication date: November 22, 2007
    Inventors: Radhakrishnan Iyer, Yi Jin, Arlene Roland, Wenqiang Zhou
  • Nucleic acid-based compounds and methods of use thereof
    Patent number: 7256179
    Abstract: The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: August 14, 2007
    Assignee: Migenix, Inc.
    Inventors: Radhakrishnan P. Iyer, Yi Jin, Arlene Roland, Wenqiang Zhou
  • Oligonucleotides having alkylphosphonate linkages and methods for their preparation
    Patent number: 7049432
    Abstract: The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers. Methods for the preparation of substantially diastereomerically pure alkylphosphonate dimers are also provided.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: May 23, 2006
    Assignees: ISIS Pharmaceuticals, Inc., McGill University
    Inventors: Muthiah Manoharan, George Just, Andrei Guzaev, Arlène Roland, Jianchao Wang, Michael E. Jung
  • Phospho-indoles as HIV inhibitors
    Publication number: 20060074054
    Abstract: 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
    Type: Application
    Filed: September 16, 2005
    Publication date: April 6, 2006
    Inventors: Richard Storer, Cyril Dousson, Francois-Rene Alexandre, Arlene Roland
  • Nucleic acid-based compounds and methods of use thereof
    Publication number: 20050143337
    Abstract: The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units.
    Type: Application
    Filed: February 14, 2005
    Publication date: June 30, 2005
    Applicant: Migenix, Inc.
    Inventors: Radhakrishnan Iyer, Yi Jin, Arlene Roland, Wenqiang Zhou
  • Nucleic acid-based compounds and methods of use thereof
    Patent number: 6881831
    Abstract: The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: April 19, 2005
    Assignee: Migenix Inc.
    Inventors: Radhakrishnan P. Iyer, Yi Jin, Arlene Roland, Wenqiang Zhou
  • Inhibitors of RNA dependent RNA polymerase and uses thereof
    Publication number: 20040106785
    Abstract: The invention herein provides novel viral DNA polymerase compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with viral DNA polymerase activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: July 25, 2003
    Publication date: June 3, 2004
    Applicant: Micrologix Biotech Inc.
    Inventors: Robert Deziel, Eric Fournier, Arlene Roland
  • Combinatorial library synthesis and pharmaceutically active compounds produced thereby
    Publication number: 20040087540
    Abstract: The invention provides new methods for synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications, including treatment of viral or bacterial infections and associated diseases and disorders.
    Type: Application
    Filed: April 28, 2003
    Publication date: May 6, 2004
    Applicant: Micrologix Biotech Inc.
    Inventors: Wenqiang Zhou, Yi Jin, Arlene Roland, Radhakrishnan Parameswaran Iyer
  • Combinatorial library synthesis and pharmaceutically active compounds produced thereby
    Patent number: 6620796
    Abstract: The invention provides new methods for synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications, including treatment of viral or bacterial infections and associated diseases and disorders.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: September 16, 2003
    Assignee: Micrologix Biotech Inc.
    Inventors: Wenqiang Zhou, Yi Jin, Arlene Roland, Radhakrishnan Iyer
  • Attachment of thiophosphate tethered oligonucleotides to a solid surface
    Publication number: 20030143331
    Abstract: The present invention provides an alternative method of attaching a 3′-thiophosphate mononucleotide or oligonucleotide to a solid support. The method permits chemoselective binding of a thiophosphate mono- or oligonucleotide to a solid support. The present invention is useful in production of microarrays, chips, beads or other solid matrices for gene expression profiling, single nucleotide polymorphism, and pharmacogenomics, target validation, sequencing and for any application that involves contacting a target nucleic acid sequence with a support-bound probe.
    Type: Application
    Filed: October 3, 2002
    Publication date: July 31, 2003
    Applicant: Micrologix Biotech Inc.
    Inventors: Radhakrishnan P. Iyer, Rajendra K. Pandey, Satya N. Kuchimanchi, Arlene Roland
  • Nucleic acid-based compounds
    Publication number: 20030138797
    Abstract: The present invention relates to novel phosphoramidate compounds and libraries containing such compounds, and methods for preparing such compounds. Compounds of the invention will be useful in a variety of applications, e.g. as a nucleoside or oligonucleotide therapeutic agent, or for diagnostic or analytical applications, e.g. as a capture probe in a hybridization assay.
    Type: Application
    Filed: June 28, 2002
    Publication date: July 24, 2003
    Applicant: Micrologix Biotech Inc.
    Inventors: Radhakrishnan P. Iyer, Yi Jin, Arlene Roland
  • Nucleic acid-based compounds and methods of use thereof
    Publication number: 20030109471
    Abstract: The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units.
    Type: Application
    Filed: May 15, 2002
    Publication date: June 12, 2003
    Inventors: Radhakrishnan P. Iyer, Yi Jin, Arlene Roland, Wenqiang Zhou