Abstract: This composition contains, by way of main active principle, in a pharmaceutically acceptable carrier, at least one substance belonging to the carotenoid family and chosen, in particular, from the group consisting of .alpha.-carotene, .delta.-carotene, .gamma.-carotene, .beta., .beta.-carotene-4,4'-dione, ethyl 8'-apo-.beta.-caroten-8'-oate, .beta.-apo-8'-carotenal, .psi.,.psi.-carotene, .psi.,.psi.-carotene-16,16'-diol and .psi.,.psi.-caroten-16-ol. This composition preferably contains from 0.001 to 10% by weight of active principle relative to the total weight of the composition and takes the form of a suspension, tablets or gelatin capsules. The pharmacological activity of this drug is an activity which inhibits comedo formation, the latter being due to an irritation caused by an excess of lipid oxide (oxidized squalene).