Patent number: 7829717
Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R5, m and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.
Type:
Grant
Filed:
September 15, 2005
Date of Patent:
November 9, 2010
Assignee:
OSI Pharmaceuticals, Inc.
Inventors:
Arlindo L. Castelhano, Andrew Crew, Hanqing Dong, An-Hu Li, Li Qiu, Alun Smith, Lawrence Tardibono, Tao Zhang