Abstract: Photoacoustic voltage dependent dyes and their use in measuring an electrophysiological activity in a subject in vivo are disclosed.

Abstract: A system for monitoring an ablation therapy may include an ultrasound transmitter to transmit ultrasound signals through a region of tissue during an ablation procedure, an ultrasound receiver to receive the ultrasound signals after the ultrasound signals have passed through the region of tissue, and a signal processor to communicate with the ultrasound transmitter and the ultrasound receiver to obtain a set of measurements related to the ultrasound signals transmitted through the region of tissue during the ablation procedure. The signal processor may determine one or more acoustic characteristics of the ultrasound signals transmitted through the region of tissue based on the set of measurements and generate an image representing a thermal map of the region of tissue during the ablation procedure based on a mapping between the one or more acoustic characteristics of the ultrasound signals and changes in temperature.

Abstract: Imaging of internal structure of a patient, such as the prostate, is performed using ultrasound tomography by inserting a first ultrasound probe into the rectum of the patient, positioning a second ultrasound probe on an abdomen of the patient, and aligning the first and second ultrasound probes with one another to obtain acoustic information for reconstructing tomographic images of the internal structure. Light sources can also be shined to the tissue of interest, such as prostate say by a transurethral catheter thus making photoacoustic waves that can be received by the said TRUS or TRAB/TRPR transducers to reconstruct photoacoustic tomographic image of the tissue, as well.

Abstract: Photoacoustic voltage dependent dyes and their use in measuring an electrophysiological activity in a subject in vivo are disclosed.