Abstract: DNA array for detecting canine toll-like receptor gene mutations New mutations in canine toll-like receptor genes are provided. The invention relates further to DNA arrays comprising oligonucleotides capable of hybridizing to at least a TLR gene fragment codifying for at least one of the new mutations leading to non-functional proteins. The invention also includes methods for the analysis of mutations and for the genetic predisposition of an individual of Canis genera to suffer from any disease related with dysfunctions of the innate immunity system. The invention also provides a method for the individual identification of canine subjects.

Abstract: A method for predicting risk of joint dysplasia, osteoarthritis and/or a condition that is secondary to joint dysplasia in a mammalian subject of the order Carnivora, the method comprising: (a) determining the genotype of said subject in respect of one or more genetic polymorphisms and/or alterations, such as polymorphisms in the CHST3 gene; and (b) providing a prediction of said risk based on said genotype. Products for use in such a method and related methods of determining propensity of a subject to respond to therapy and of selective breeding, are also disclosed.