Patents by Inventor Armando Karara

Armando Karara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytochrome P450 arachidonic acid epoxygenase genetic mutation associated with hypertension
    Patent number: 5834293
    Abstract: The invention provides an isolated nucleic acid encoding the rat P450 2C11 arachidonic acid epoxygenase, or a human homologue thereof, having a mutation associated with salt induced hypertension. Also provided is an isolated cell line expressing the epoxygenase encoded by the mutated nucleic acid, and a non-human transgenic animal having a germ line insertion of the mutated nucleic acid. Also provided is a method of screening a compound for efficacy in treating salt induced hypertension comprising administering the compound to such a non-human transgenic animal, and detecting an improvement in the animal's hypertension. The invention also provides a method of screening a human subject for a genetic predisposition to salt induced hypertension comprising detecting a mutation in a human homologue of a rat P450 2C11 arachidonic acid epoxygenase gene which affects normal epoxygenase activity.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: November 10, 1998
    Assignee: Vanderbilt University
    Inventors: Jorge H. Capdevila, Keiko Makita, Armando Karara