Abstract: An orally administered medicant composition useful for the treatment of diabetes mellitus; whose constituents are a hypoglycemic of the sulphonylurea derivative type together with an anti-bacterial sulfonamide and ascorbic acid. A unit dosage of one preferred formulation is comprised of 0.5 gram tolbutamide, 100 milligrams sulfamethox-pyridazine and 50 milligrams ascorbic acid. A typical treatment that has proven successful in correcting numerous diabetic conditions may begin with as many as six unit dosages the first day, thereafter the dosage is reduced, then sustained at a level in accordance to the response of the patient; treatment is terminated usually after a six month period.