Abstract: The present invention relates to an oral dissolvable film (ODF), methods of orally administering the same, and methods of manufacturing the same. The ODF includes a high load of binder. Such an ODF, containing a high load of binder, can achieve the requisite physical and performance characteristics and can be manufactured on a commercial scale, while demonstrating that the ODF is safe and effective to consumers for its intended use. This also includes formulating and configuring the ODF to deliver the API as desired, via, e.g., enteral, transmucosal, sublingual, and/or buccal, when the administration is oral.

Abstract: This disclosure features gastro-retentive (GR) modified release pharmaceutical dosage forms (e.g., solid dosage forms, e.g., tablets, e.g., bilayer tablets) that are useful for the oral administration of oprozomib, or a pharmaceutically acceptable salt thereof, to a human or animal subject as well as methods of making and using the dosage form.

Abstract: This disclosure features immediate release pharmaceutical formulations (e.g., solid dosage forms, e.g., tablets) that are useful for the oral administration of oprozomib, or a pharmaceutically acceptable salt thereof, to a human or animal subject as well as methods of making and using the formulations.