Abstract: Provided are systems and methods for multi-layer caching of data. An example method commences with creating a data structure on top of an information retrieval library. The data structure is designed to access data associated with the information retrieval library through a local index. The method includes creating a plurality of ordered cache layers for the data accessed via the local index. The plurality of ordered cache layers are ordered based on frequency of access and a last layer is used to access the data over a network. The method then continues with receiving a search query. The method further includes determining that the search query is for the data associated with the last layer. The method further continues with executing, using the local index, the search query locally to retrieve a matching document from the data associated with the last layer remotely.

Abstract: An antibody or an antigen-binding fragment thereof binds to an antigen of the bacterium Candidatus savagella and inhibits the adhesion of the bacterium to intestinal epithelial cells; and/or depletes the bacterium. A drug has the antibody or an antigen-binding fragment thereof. A kit has the antibody or an antigen-binding fragment thereof for reduction of Th17 cell proliferation, Th17 cell differentiation or Th17 cell activity and/or inhibition of the formation of antibodies against endogenous antigens by B cells. The kit can contain an antibiotic. A method for producing the antibody involves immunizing chickens with an immunogenic peptide from an antigen of the bacterium Candidatus savagella, and recovering and purifying the antibodies formed in the chickens or in an egg laid by said chickens. A method for producing the drug involves producing the antibody or an antigen-binding fragment thereof, and formulating the antibody or an antigen-binding fragment thereof as a drug.

Abstract: The invention relates to a rotor (1, 71) for a camshaft adjuster, comprising a substantially annular rotor basic body (3, 73) which has an end surface (11, 91) with a contour (15, 89) which extends in an axial direction, wherein the contour (15, 89) has an asymmetry such that precisely one position is predefined for the axial attachment of the rotor basic body (3, 73) to a camshaft (31, 112). A rotor (1, 71) with a contour (15, 89) of this type makes centering on a camshaft (31, 112) possible in a manner which is cost-neutral and can be easily implemented in terms of manufacturing technology. Furthermore, the invention relates to a camshaft adjusting system (111) with an above-mentioned rotor (1, 71).

Abstract: A camshaft phaser (1), including a drive element (2) and a driven element (3) that can be rotated relative to each other by hydraulic medium, and the drive element (2) or the driven element (3) has sealing elements (6) that are arranged in grooves (7) provided for this purpose, and the groove (7) has an undercut (8) that cooperates with a complementary geometry (12) of the sealing element (6).

Abstract: A rotor (1, 21, 41) for a camshaft adjuster (61), having a rotor base body (3, 23, 43) and a number of rotor blades (5, 25, 45) extending radially outwards and located on the rotor base body (3, 23, 43), each of the blades having a blade end (7, 27, 47). To reduce leakage, the blade ends (7, 27, 47) of the rotor blades (5, 25, 45) take the form of sealing fins (9, 31, 49) that can be deformed radially outwards. A rotor (1, 21, 41) of this type affords the possibility of reducing leakage in a camshaft adjuster (61) using simple engineering and without added costs. The invention also relates to a camshaft adjuster (61) for an internal combustion engine, including a rotor (1, 21, 41) of this type.

Abstract: The invention relates to a rotor (1, 71) for a camshaft adjuster, comprising a substantially annular rotor basic body (3, 73) which has an end surface (11, 91) with a contour (15, 89) which extends in an axial direction, wherein the contour (15, 89) has an asymmetry such that precisely one position is predefined for the axial attachment of the rotor basic body (3, 73) to a camshaft (31, 112). A rotor (1, 71) with a contour (15, 89) of this type makes centring on a camshaft (31, 112) possible in a manner which is cost-neutral and can be easily implemented in terms of manufacturing technology. Furthermore, the invention relates to a camshaft adjusting system (111) with an above-mentioned rotor (1, 71).

Abstract: A camshaft adjuster (31) for an internal combustion engine, including a drive pinion (33) that can be connected rotationally fast to a crankshaft, a driven pinion (1) with an inner gearing (5) and arranged for rotation relative to the drive pinion (33) about an axis of rotation (37) as well as an adapter (13) that is arranged on an inner circumference (3) of the driven pinion (1) and through which the driven pinion (1) can be connected rotationally fast to a camshaft. For this purpose, the adapter (13) is fixed via the inner gearing (5) on the inner circumference (3) of the driven pinion (1). A fixing of this type enables manufacturing of a camshaft adjuster (31) with the lowest possible complexity of fabrication and correspondingly low costs.

Abstract: The present invention relates to a method for the preparation of a therapeutical composition, in particular, the present invention relates to a method for treating dendritic cells with a combination of at least one interferon gamma receptor agonist and at least one toll like receptor 2 and/or TLR 6 agonist and using these pretreated dendritic cells for the preparation of a therapeutical composition. Moreover, the present invention relates to a therapeutical composition containing dendritic cells and the use thereof for the treatment of various diseases and disorders.

Abstract: A rotor (1, 21, 41) for a camshaft adjuster (61), having a rotor base body (3, 23, 43) and a number of rotor blades (5, 25, 45) extending radially outwards and located on the rotor base body (3, 23, 43), each of the blades having a blade end (7, 27, 47). To reduce leakage, the blade ends (7, 27, 47) of the rotor blades (5, 25, 45) take the form of sealing fins (9, 31, 49) that can be deformed radially outwards. A rotor (1, 21, 41) of this type affords the possibility of reducing leakage in a camshaft adjuster (61) using simple engineering and without added costs. The invention also relates to a camshaft adjuster (61) for an internal combustion engine, including a rotor (1, 21, 41) of this type.

Abstract: A device (1) for aligning a guide wire with a femur, comprising: an indication means (2) comprising at least two arms (3), each having a section (4) that is part-circular; an alignment means (6) for locating a portion of the bone for insertion of the guide wire, in use; and a body (18) connected to the indication means (2) and the alignment means (6), wherein the sections of the at least two arms (3) of the indication means (2) can be moved from an open to a closed position, and wherein in the open position the sections of the arms (3) can pass over the femoral head, and wherein in the closed position the sections of the arms (3) form a ring that has dimensions corresponding to a femoral implant component internal diameter. A system and method of aligning a guide wire with a femur.

Abstract: The present invention relates to a method for the preparation of a therapeutical composition, in particular, the present invention relates to a method for treating dendritic cells with a combination of at least one interferon gamma receptor agonist and at least one toll like receptor 2 and/or TLR 6 agonist and using these pretreated dendritic cells for the preparation of a therapeutical composition. Moreover, the present invention relates to a therapeutical composition containing dendritic cells and the use thereof for the treatment of various diseases and disorders.

Abstract: A distributing valve, in particular a hydraulic 3/2 path distributing valve is provided, having an actuating unit (1) and a valve unit (2) interacting therewith, wherein the actuating unit (1) includes at least one coil (3) and a movable armature (4), the valve unit (2) includes a valve element interacting with the armature (4), controlling connections between the valve unit (2) channels for directing a pressure medium and is provided with sealing bodies (13, 15) corresponding to valve seats (8, 9) pressed against the valve unit (2) housing, and a valve body (11) interacting with the armature (4), guided in the valve unit (2) housing (tubular body (6)) of the valve unit (2) and is connect to the sealing bodies (13,15).

Abstract: The present invention relates to a method for the preparation of a therapeutical composition, in particular, the present invention relates to a method for treating dendritic cells with a combination of at least one interferon gamma receptor agonist and at least one toll like receptor 2 and/or TLR 6 agonist and using these pretreated dendritic cells for the preparation of a therapeutical composition. Moreover, the present invention relates to a therapeutical composition containing dendritic cells and the use thereof for the treatment of various diseases and disorders.

Abstract: An electromagnetic hydraulic valve having an electromagnet with a coil winding arranged on a spool, and a magnet housing, a valve stem having a pressure connection, a tank connection and a consumer connection. The spool and the valve stem are a one-piece plastic body which has an axial longitudinal bore which is an armature space for a magnet armature and also is a control region for a closing body. The magnet housing, with a collar which projects into the longitudinal bore, forms a top magnet pole of the electromagnet. A bottom magnet pole, connected to the magnet housing in a magnetically conductive manner, of the electromagnet likewise projects into the longitudinal bore of the plastic body.

Abstract: An electromagnetic hydraulic valve having an electromagnet with a coil winding arranged on a spool, and a magnet housing, a valve stem having a pressure connection, a tank connection and a consumer connection. The spool and the valve stem are a one-piece plastic body which has an axial longitudinal bore which is an armature space for a magnet armature and also is a control region for a closing body. The magnet housing, with a collar which projects into the longitudinal bore, forms a top magnet pole of the electromagnet. A bottom magnet pole, connected to the magnet housing in a magnetically conductive manner, of the electromagnet likewise projects into the longitudinal bore of the plastic body.