Patents by Inventor Armin Gerhardt

Armin Gerhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Eplerenone for phenotyping of CYP3A5 enzyme activity in saliva samples
    Patent number: 11747352
    Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize substrate for CYP3A5 comprising eplerenone which may be administered orally to a subject. Subsequently, metabolites of eplereone may be detected in the subject's saliva as well as any non- metabolized eplerenone to calculate a metabolic ratio for CYP3A5 enzyme in order to generate a phenytopic CYP3A5 enzyme profile for the subject.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: September 5, 2023
    Assignee: Concordia University, Inc.
    Inventors: Joseph McGraw, Armin Gerhardt
  • COMPOSITIONS FOR CYP450 PHENOTYPING USING SALIVA SAMPLES
    Publication number: 20210139945
    Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize a mélange of substrates for different CYP450 enzymes which may be administered orally to a patient. Subsequently, the metabolites of the substrates may be detected in the patient's saliva as well as any non-metabolized substrates to calculate a metabolic ratio for any given CYP450 enzyme in order to generate a phenytopic CYP450 enzyme profile for the patient.
    Type: Application
    Filed: January 20, 2021
    Publication date: May 13, 2021
    Inventors: Joseph McGraw, Armin Gerhardt
  • Compositions for CYP450 phenotyping using saliva samples
    Patent number: 10927398
    Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize a mélange of substrates for different CYP450 enzymes which may be administered orally to a patient. Subsequently, the metabolites of the substrates may be detected in the patient's saliva as well as any non-metabolized substrates to calculate a metabolic ratio for any given CYP450 enzyme in order to generate a phenotypic CYP450 enzyme profile for the patient.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: February 23, 2021
    Assignee: Concordia University Inc.
    Inventors: Joseph McGraw, Armin Gerhardt
  • Eplerenone for Phenotyping of CYP3A5 Enzyme Activity in Saliva Samples
    Publication number: 20200371123
    Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize substrate for CYP3A5 comprising eplerenone which may be administered orally to a subject. Subsequently, metabolites of eplereone may be detected in the subject's saliva as well as any non- metabolized eplerenone to calculate a metabolic ratio for CYP3A5 enzyme in order to generate a phenytopic CYP3A5 enzyme profile for the subject.
    Type: Application
    Filed: August 7, 2018
    Publication date: November 26, 2020
    Inventors: Joseph McGraw, Armin Gerhardt
  • COMPOSITIONS FOR CYP450 PHENOTYPING USING SALIVA SAMPLES
    Publication number: 20190264252
    Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize a mélange of substrates for different CYP450 enzymes which may be administered orally to a patient. Subsequently, the metabolites of the substrates may be detected in the patient's saliva as well as any non-metabolized substrates to calculate a metabolic ratio for any given CYP450 enzyme in order to generate a phenotypic CYP450 enzyme profile for the patient.
    Type: Application
    Filed: November 30, 2016
    Publication date: August 29, 2019
    Applicant: Concordia University, Inc.
    Inventors: Joseph McGraw, Armin Gerhardt