Patents by Inventor Armin Hekele

Armin Hekele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED NUCLEASES THAT TARGET HUMAN AND CANINE FACTOR VIII GENES AS A TREATMENT FOR HEMOPHILIA A
    Publication number: 20200299658
    Abstract: The present invention encompasses engineered nucleases which recognize and cleave a recognition sequence within the int22h-1 sequence of a Factor VIII gene. The present invention also encompasses methods of using such engineered nucleases to make genetically-modified cells, and the use of such cells in a pharmaceutical composition and in methods for treating hemophilia A. Further, the invention encompasses pharmaceutical compositions comprising engineered nuclease proteins, nucleic acids encoding engineered nucleases, or genetically-modified cells of the invention, and the use of such compositions for treating of hemophilia A.
    Type: Application
    Filed: November 1, 2018
    Publication date: September 24, 2020
    Applicant: Precision BioSciences, Inc.
    Inventors: Armin Hekele, Clayton Beard, Derek Jantz, James Jefferson Smith, Victor Bartsevich
  • SELF REPLICATING RNA MOLECULES AND USES THEREOF
    Publication number: 20110300205
    Abstract: This application discloses self-replicating RNA molecules that contain modified nucleotides, compositions that contain the self-replicating RNA molecules, and methods for using the self-replicating RNA molecules, for example, to raise an immune response.
    Type: Application
    Filed: July 6, 2010
    Publication date: December 8, 2011
    Applicant: Novartis AG
    Inventors: Andrew Geall, Armin Hekele, Christian Mandl