Abstract: The present disclosure relates to compounds. and to their pharmaceutical compositions. that inhibit dipeptidyl peptidase IV (DPP4). Hie compounds selectively promote the proliferation of alveolar type 2 cells (AEC2s) and are useful in therapeutic methods of treating diseases whose etiology. for example. derives from epithelial degeneration and maladaptive remodeling, such as pulmonary' diseases like idiopathic pulmonary fibrosis (IFF), acute respiratory' distress syndrome (ARDS), and infant respiratory' distress syndromes (IRDS).

Abstract: Existing systems for behavioural tracking and identification have the disadvantage that they do not analyse data in behavioural aspects. As a result, they lack ability to pre-empt scenarios involving actions that adversely affect user health. The disclosure herein generally relates to behavior prediction, and, more particularly, to a method and system for identifying unhealthy behavior trigger and providing nudges. The system generates a casual inference model, which is a reverse causality model facilitating mapping of context with one or more behaviour of the user. The system further collects and processes real-time data using the casual inference model, to perform behavioral analysis of the user.

Abstract: A system and method for routing requests to an API to two or more API endpoints are disclosed. The system comprises at least a gateway router and a configuration server. When software is executed, the system transmits, from the configuration server to the gateway router, information setting a desired proportion of API requests to be allocated to each of the two or more API endpoints. When API requests are received, the gateway router forwards the API requests to the API endpoints in the desired proportion. The system receives metrics data from one or more backend entities upon which at least one of the API endpoints relies for data or other services, and determines that an adverse event is underway or imminent based at least in part on the received metrics data. In response to the event, it forwards the API requests in a second proportion different from the desired proportion.

Abstract: This disclosure relates generally to method and system for performing negotiation task using reinforcement learning agents. Performing negotiation on a task is a complex decision making process and to arrive at consensus on contents of a negotiation task is often expensive and time consuming due to the negotiation terms and the negotiation parties involved. The proposed technique trains reinforcement learning agents such as negotiating agent and an opposition agent. These agents are capable of performing the negotiation task on a plurality of clauses to agree on common terms between the agents involved. The system provides modelling of a selector agent on a plurality of behavioral models of a negotiating agent and the opposition agent to negotiate against each other and provides a reward signal based on the performance. This selector agent emulate human behavior provides scalability on selecting an optimal contract proposal during the performance of the negotiation task.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for inhibiting the ENL YEATS domain. Further, provided herein are compounds, pharmaceutical compositions, and methods for the treatment of leukemia.

Abstract: In presence of high-cardinality treatment variables, number of counterfactual outcomes to be estimated is much larger than number of factual observations, rendering the problem to be ill-posed. Furthermore, lack of information regarding the confounders among large number of covariates pose challenges in handling confounding bias. Essential is to find lower-dimensional manifold where an equivalent problem of causal inference can be posed, and counterfactual outcomes can be computed.

Abstract: Causality is a crucial paradigm in several domains where observational data is available. Primary goal of Causal Inference (CI) is to uncover cause-effect relationship between entities. Conventional methods face challenges in providing an accurate CI framework due to cofounding and selection bias in multiple treatment scenario. The present disclosure computes a Propensity Score (PS) from a received CI data for the plurality of subjects under test for a treatment. A Generalized Propensity Score (GPS) is computed for a plurality of treatments corresponding to the plurality of subjects by using the PS. Further, a plurality of task batches are created using the GPS and given as input to the DNN for training. Errors in factual data and in balancing representation of the DNN are rectified using a novel loss function. The trained DNN is further used for predicting the counter factual treatment response corresponding to the factual treatment data.

Abstract: A method of geosteering in a wellbore construction process uses an earth model that defines boundaries between formation layers and petrophysical properties of the formation layers in a subterranean formation. Sensor measurements related to the wellbore construction process are inputted to the earth model. An estimate is obtained for a relative geometrical and geological placement of the well path with respect to a geological objective using a trained reinforcement learning agent. An output action based on the sensor measurement for influencing a future profile of the well path with respect to the estimate.

Abstract: This disclosure relates generally to method and system for performing negotiation task using reinforcement learning agents. Performing negotiation on a task is a complex decision making process and to arrive at consensus on contents of a negotiation task is often expensive and time consuming due to the negotiation terms and the negotiation parties involved. The proposed technique trains reinforcement learning agents such as negotiating agent and an opposition agent. These agents are capable of performing the negotiation task on a plurality of clauses to agree on common terms between the agents involved. The system provides modelling of a selector agent on a plurality of behavioral models of a negotiating agent and the opposition agent to negotiate against each other and provides a reward signal based on the performance. This selector agent emulate human behavior provides scalability on selecting an optimal contract proposal during the performance of the negotiation task.

Abstract: The present invention provides a process for purifying natural gas, comprising removing mercaptans from a natural gas stream by a combination of an amine-based separation unit and a selective oxidation unit to obtain a purified natural gas stream, wherein at least part of the mercaptans are converted into at least elemental sulphur in the selective oxidation unit by selective catalytic oxidation.

Abstract: The present invention provides a process for the selective oxidation of hydrogen sulphide contained in a hydrogen sulphide-containing hydrocarbon feed gas to elemental sulphur. The hydrogen sulphide-containing hydrocarbon feed gas and a sulphur dioxide-containing gas are supplied to a reaction zone containing a TiO2-comprising catalyst, wherein elemental sulphur and a gaseous stream depleted in hydrogen sulphide are formed. The gas feeds are contacted with the TiO2 containing catalyst at elevated pressure and at a temperature in the range of from 120 and below 160 ° C., under such conditions that the elemental sulphur formed is essentially in liquid form. At least part of the sulphur dioxide-containing gas is obtained by combusting elemental sulphur to obtain a gaseous mixture of sulphur dioxide and nitrogen and then concentrating the gaseous mixture to provide the sulphur dioxide-containing gas.

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.

Abstract: The present invention provides a process for the selective oxidation of hydrogen sulphide contained in a hydrogen sulphide-containing hydrocarbon feed gas to elemental sulphur. The hydrogen sulphide-containing hydrocarbon feed gas and a sulphur dioxide-containing gas are supplied to a reaction zone containing a TiO2-comprising catalyst, wherein elemental sulphur and a gaseous stream depleted in hydrogen sulphide are formed. The gas feeds are contacted with the TiO2 containing catalyst at elevated pressure and at a temperature in the range of from 120 and below 160° C., under such conditions that the elemental sulphur formed is essentially in liquid form. At least part of the sulphur dioxide-containing gas is obtained by combusting elemental sulphur to obtain a gaseous mixture of sulphur dioxide and nitrogen and then concentrating the gaseous mixture to provide the sulphur dioxide-containing gas.

Abstract: The present invention provides a process for purifying natural gas, comprising removing mercaptans from a natural gas stream by a combination of an amine-based separation unit and a selective oxidation unit to obtain a purified natural gas stream, wherein at least part of the mercaptans are converted into at least elemental sulphur in the selective oxidation unit by selective catalytic oxidation.

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.

Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula 1: wherein Q is an optionally substituted azetidinyl, pyrrolidinyl, piperidyl, and indolinyl; or Q is NR25R26; and A, R5, R6, R7, R8, R9, R25, R26 and Ar are substituents.

Abstract: A process for improving the smell of a stream of elemental sulphur comprising an organic polysulphide and/or a thiol, the process comprising the following step: (a) heating the stream of liquid elemental sulphur comprising an organic polysulphide and/or a thiol at a heating temperature in the range of from 360 to 700° C., at a pressure that is sufficient to maintain a liquid elemental sulphur phase to obtain heat-treated elemental sulphur.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.