Abstract: An arrangement for monitoring an aseptic manufacturing process includes product condition sensors capable of making closely spaced measurements of a product condition such as temperature or humidity. The measurements are made using closely spaced sensors arranged in a linear array on a single probe, which may be used to take measurements at multiple levels within the product. Data from the sensors is transmitted to a data collection point via short range wireless digital communications. The sensors may be used to measure temperature and humidity at a single point. For example, when the sensors are used in pharmaceutical freeze drying, the location of a sublimation front may be calculated for each vial, and the freeze drying process may be controlled using the data.

Abstract: A compact freeze dryer removes a liquid from a bulk powder product. The freeze dryer utilizes a single cryogenic vessel for both (1) freezing the liquid contained in the bulk product, and (2) condensing vapor resulting from sublimating the frozen liquid. A vacuum pump is connected to the cryogenic vessel for drawing a vacuum in the cryogenic vessel and in a drying vessel. Vapor resulting from subliming the frozen liquid in the drying vessel is drawn into the cryogenic vessel and condensed.

Abstract: An arrangement for monitoring an aseptic manufacturing process includes product condition sensors capable of making closely spaced measurements of a product condition such as temperature or humidity. The measurements are made using closely spaced sensors arranged in a linear array on a single probe, which may be used to take measurements at multiple levels within the product. Data from the sensors is transmitted to a data collection point via short range wireless digital communications. The sensors may be used to measure temperature and humidity at a single point. For example, when the sensors are used in pharmaceutical freeze drying, the location of a sublimation front may be calculated for each vial, and the freeze drying process may be controlled using the data.

Abstract: An arrangement for monitoring an aseptic manufacturing process includes product condition sensors capable of making closely spaced measurements of a product condition such as temperature or humidity. The measurements are made using closely spaced sensors arranged in a linear array on a single probe, which may be used to take measurements at multiple levels within the product. Data from the sensors is transmitted to a data collection point via short range wireless digital communications. The sensors may be used to measure temperature and humidity at a single point. For example, when the sensors are used in pharmaceutical freeze drying, the location of a sublimation front may be calculated for each vial, and the freeze drying process may be controlled using the data.

Abstract: A freeze drying vessel (302) having a freeze drying chamber (304) that includes sloped horizontal shelves (352) that receive frozen particles (282). Each shelf is sloped relative to a horizontal axis (390) and arranged such that a downward slope between successive shelves alternates between first (392) and second (394) directions. At least one connecting member (374, 376, 378, 380, 382, 384, 386, 386, 388) is attached between pairs of shelves. At least one connecting member is attached to an associated vibration element (396, 398, 400, 402) located outside the drying chamber. Each vibration element vibrates a pair of shelves to cause the frozen particles to advance relative to an associated shelf and drop downward from shelf to shelf wherein the shelves heat the frozen particles to promote sublimation to form freeze dried product (284).

Abstract: In a system and method for controlling a freeze drying process, a diagnostics server (718) is connected for receiving time series data from a freeze drying system (710, 711). The diagnostics server uses a tuned freeze drying system mathematical model to analyze the time series data to predict a system event, and alter the freeze drying process. An analytics server (730) is connected for secure communication with the diagnostics server, and creates and tunes the freeze drying system mathematical model. An equipment provider service and diagnostic cloud (735) may apply learning algorithms to the time series data to enhance diagnostic tools and provide predictive maintenance and diagnostic services to the operator of the first production sites using the diagnostic tools.

Abstract: A freeze drying system (200) having a nozzle (30) operated at a setpoint pressure to generate fluid product drops (242) for freezing in a freezing chamber (244) of a freezing vessel (228). The freezing chamber includes an inner wall (250) that defines a cavity (254) and an outer wall (252) having an inlet (260) that extends from a location on the outer wall that is lower than an outlet (262). A cooling fluid flows through the inlet, cavity and outlet to form a freezing zone (280). A drying chamber (304) having sloped shelves (352) receives frozen particles (282) from the freezing chamber. A heating element (418) is associated with each shelf that heats the frozen particles to promote sublimation. Vibration elements (396, 398, 400, 402) located outside the drying chamber vibrate the shelves causing the frozen particles to move from shelf to shelf to form freeze dried product (284).

Abstract: A freeze drying vessel (302) having a freeze drying chamber (304) that includes sloped horizontal shelves (352) that receive frozen particles (282). Each shelf is sloped relative to a horizontal axis (390) and arranged such that a downward slope between successive shelves alternates between first (392) and second (394) directions. At least one connecting member (374, 376, 378, 380, 382, 384, 386, 386, 388) is attached between pairs of shelves. At least one connecting member is attached to an associated vibration element (396, 398, 400, 402) located outside the drying chamber. Each vibration element vibrates a pair of shelves to cause the frozen particles to advance relative to an associated shelf and drop downward from shelf to shelf wherein the shelves heat the frozen particles to promote sublimation to form freeze dried product (284).

Abstract: A freeze dryer processes a bulk material including a liquid, and produces a product including the freeze dried material borne on a substrate. The material is introduced in a freezing chamber as a droplet stream that impinges on the substrate. The liquid in the material is frozen after it contacts the substrate. The substrate bearing the material is transferred through a vacuum lock into a vacuum drying chamber where the frozen liquid sublimates under vacuum and applied heat.

Abstract: In a system and method for controlling a freeze drying process, a diagnostics server (718) is connected for receiving time series data from a freeze drying system (710, 711). The diagnostics server uses a tuned freeze drying system mathematical model to analyze the time series data to predict a system event, and alter the freeze drying process. An analytics server (730) is connected for secure communication with the diagnostics server, and creates and tunes the freeze drying system mathematical model. An equipment provider service and diagnostic cloud (735) may apply learning algorithms to the time series data to enhance diagnostic tools and provide predictive maintenance and diagnostic services to the operator of the first production sites using the diagnostic tools.

Abstract: An arrangement for monitoring an aseptic manufacturing process includes product condition sensors capable of making closely spaced measurements of a product condition such as temperature or humidity. The measurements are made using closely spaced sensors arranged in a linear array on a single probe, which may be used to take measurements at multiple levels within the product. Data from the sensors is transmitted to a data collection point via short range wireless digital communications. The sensors may be used to measure temperature and humidity at a single point. For example, when the sensors are used in pharmaceutical freeze drying, the location of a sublimation front may be calculated for each vial, and the freeze drying process may be controlled using the data.

Abstract: An arrangement for monitoring a freeze drying process includes product condition sensors for product condition measurement within product vials. The product condition sensors are bimetal junctions deposited on a substrate using an ink jet printing process. The substrate may be a flexible film applied to an interior surface of the product vial, or may be the vial surface itself. The bimetal junction may be printed using a roll-roll inkjet printing process with metallic nanoparticle inks. Multiple closely-spaced bi-metal junctions are provided in each measurement vial. Data from the sensors is transmitted to a data collection point via short range wireless digital communications. The location of a sublimation front may be calculated for each measured vial, and the freeze drying process may be controlled using the data.

Abstract: A freeze dryer processes aseptic bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen to produce a frozen powder. The frozen powder is freeze dried in a vessel by dielectrically heating the frozen powder using electromagnetic radiation such as microwave radiation or infrared radiation, and the frozen powder is continuously agitated using a sterilizable apparatus such as a series of vibrating shelves to maintain even heating and to prevent agglomeration.

Abstract: An air conditioning control system includes a plurality of air vents in a space and a plurality of sensors configured to generate sensor input including an estimated temperature of at least one target surface of an occupant or object in the space. The system further includes one or more processors configured to execute a thermal control model to generate airflow parameters for each vent based on the sensor input, to control the estimated temperature to trend toward a respective target temperature for each target surface. The air vents may be installed in a vehicle, and the plurality of sensors may be installed in the vehicle or be installed in, or be an accessory of, a mobile computing device.

Abstract: An arrangement for monitoring a freeze drying process includes product condition sensors for product condition measurement within product vials. The product condition sensors are bimetal junctions deposited on a substrate using an ink jet printing process. The substrate may be a flexible film applied to an interior surface of the product vial, or may be the vial surface itself. The bimetal junction may be printed using a roll-roll inkjet printing process with metallic nanoparticle inks. Multiple closely-spaced bi-metal junctions are provided in each measurement vial. Data from the sensors is transmitted to a data collection point via short range wireless digital communications. The location of a sublimation front may be calculated for each measured vial, and the freeze drying process may be controlled using the data.

Abstract: A freeze dryer processes aseptic bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen to produce a frozen powder. The frozen powder is freeze dried in a vessel by dielectrically heating the frozen powder using electromagnetic radiation such as microwave radiation or infrared radiation, and the frozen powder is continuously agitated using a sterilizable apparatus such as a series of vibrating shelves to maintain even heating and to prevent agglomeration.

Abstract: A freeze dryer processes bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen. The resultant powder is freeze dried in a vessel, and the vessel contents is agitated to maintain product contact with heated vessel wall and to prevent agglomeration.

Abstract: An arrangement for monitoring an aseptic manufacturing process includes product condition sensors capable of making closely spaced measurements of a product condition such as temperature or humidity. The measurements are made using closely spaced sensors arranged in a linear array on a single probe, which may be used to take measurements at multiple levels within the product. Data from the sensors is transmitted to a data collection point via short range wireless digital communications. The sensors may be used to measure temperature and humidity at a single point. For example, when the sensors are used in pharmaceutical freeze drying, the location of a sublimation front may be calculated for each vial, and the freeze drying process may be controlled using the data.

Abstract: Embodiments of present disclosure relate to a control unit and method for dynamically controlling resolution of a display associated to an electronic device. In some embodiments, at least one of contextual parameters and non-contextual parameters is received, one or more portions of the display requiring resolution adjustment is determined based on the at least one of the contextual parameters and the non-contextual parameters, a resolution to be applied for each of the one or more portions of the display is evaluated based on the at least one of the contextual parameters and the non-contextual parameters, and the evaluated resolution of each of the one or more portions of the display is provided to a graphic controller of the electronic device for controlling the resolution of the display.

Abstract: Embodiments of the present disclosure disclose a method for authenticating access. The method comprises receiving a touch input from a user, where the touch input comprises selection of one or more nodes of a plurality of nodes displayed on a user interface of the system and sequence of selection of the one or more nodes. Then, method comprises determining an intensity of touch pressure on each of the selected one or more nodes. Next, the received touch input with a predefined touch input and the intensity of the touch pressure on each of the selected one or more nodes with corresponding predefined intensities of touch pressure is compared. Then, the method authenticates access to the system based on the comparison of the touch input and the comparison of the intensity of the touch pressure.