Abstract: A method for testing an avionic computer having internal parameters of which only a subset of internal parameters is accessible to a test bench. The method includes connecting the avionic computer to the test bench, equipping the test bench with a test computer having software similar to software of the avionic computer, all of the internal parameters of which are accessible to the test bench, executing the software of the avionic computer in interaction with the test bench and executing the software of the test computer at the same time as the software of the avionic computer, and visualizing internal parameters belonging to the subset of internal parameters of the avionic computer and visualizing internal parameters of the test computer, corresponding to internal parameters of the avionic computer not belonging to the subset of internal parameters of the avionic computer, to check the conformity of operation of the software.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluorescent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluorescent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.

Abstract: A test bench for generating aerodynamic loads on an actuator to be tested includes a force actuator configured to generate at least one dynamic load, the test bench being configured to transmit the dynamic load produced by the force actuator to the actuator to be tested, and a controller for controlling the dynamic load generated by the force actuator depending on a pressure, measured by a pressure sensor, inside one of the chambers of the force actuator.

Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.

Abstract: An aircraft avionics computer is equipped with a current software version comprising a set of interconnected functions. A function to be updated of the set of functions, receives, as input, function outputs of a first subset of functions of the set of functions and provides an output linked to a first input of a switch. Developing a new version of the avionics computer software comprises connecting to the avionics computer an external computer of which software comprises a new version of the function to be updated; receiving, by the new function version, function outputs of the first subset of functions; dispatching the output of the function to be updated to a second switch input; controlling the switch such that in a normal mode of operation, the switch output corresponds to the first input and in a fine-tuning mode of operation, the switch output corresponds to the second input.

Abstract: Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I are disclosed.

Abstract: Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I are disclosed.

Abstract: A test bench for generating aerodynamic loads on an actuator to be tested includes a force actuator configured to generate at least one dynamic load, the test bench being configured to transmit the dynamic load produced by the force actuator to the actuator to be tested, and a controller for controlling the dynamic load generated by the force actuator depending on a pressure, measured by a pressure sensor, inside one of the chambers of the force actuator.

Abstract: The invention relates to fluorescent/fluorogenic probes of formula (I?) or (II?): wherein Z is chosen between: —NH2 and —OH, or in the fluorescence quencher group consisting of: —NO2; —N?N—R1; R1 being any organic group that does not obscure the corresponding azo bond; —NHCO-Pept.; Pept. being a peptide residue or any organic group that does not obscure the corresponding amide bond; —O-Glyc.; Glyc. being a oligoglycoside residue that does not obscure the corresponding glycosidic bond; —O—C(O)—R2; —O—P(O)(OR2)(OR2?) and —O—S(O)2—R2; R2 and R2? being independently a hydrogen atom or an organic group that does not obscure the corresponding ester bond; and ?Ra, Rb, Rc, Rd and Re being independently a hydrogen atom or any organic group that does not obscure the corresponding arylether bond so as not to prevent its possible cleavage by a myeloperoxidase activity.

Abstract: The invention relates to fluorescent/fluorogenic probes of formula (I?) or (II?): wherein Z is chosen between: —NH2 and —OH, or in the fluorescence quencher group consisting of: —NO2; —N?N—R1; R1 being any organic group that does not obscure the corresponding azo bond; —NHCO-Pept.; Pept. being a peptide residue or any organic group that does not obscure the corresponding amide bond; —O-Glyc.; Glyc. being a oligoglycoside residue that does not obscure the corresponding glycosidic bond; —O—C(O)—R2; —O—P(O)(OR2)(OR2?) and —O—S(O)2—R2; R2 and R2? being independently a hydrogen atom or an organic group that does not obscure the corresponding ester bond; and Ra, Rb, Rc, Rd and Re being independently a hydrogen atom or any organic group that does not obscure the corresponding arylether bond so as not to prevent its possible cleavage by a myeloperoxidase activity.