Patents by Inventor Arnaud Comment
Arnaud Comment has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11925786Abstract: A system for drawing a solution is provided. The system includes a filter, a vacuum source, and an actuator. The filter has an input port, a first output port, a second output port, and a flow path defined in part by the input port and the second output port. The vacuum source is in fluid communication with the first output port and operative to apply a vacuum to the flow path. The actuator is operative to facilitate movement of the solution along the flow path.Type: GrantFiled: May 15, 2019Date of Patent: March 12, 2024Assignee: GE Precision Healthcare LLCInventors: Arnaud Comment, Rui Chen, Albert Chen, Galen Reed, Jonathan Murray
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Patent number: 10942237Abstract: A system for hyperpolarizing a substance is provided. The system includes a cryostat and a polarizer. The cryostat is operative to generate radicals within the substance by exposing the substance to electromagnetic radiation. The polarizer is operative to hyperpolarize the substance via the radicals. Once the substance is polarized, the radicals contained within the substance are quenched by adjusting a temperature of the substance to greater than or equal to a melting point of the substance. In embodiments, the polarizer may then rapidly freeze the substance.Type: GrantFiled: May 7, 2019Date of Patent: March 9, 2021Assignee: GE Precision Healthcare LLCInventors: Arnaud Comment, Albert Chen
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Publication number: 20200360603Abstract: A system for drawing a solution is provided. The system includes a filter, a vacuum source, and an actuator. The filter has an input port, a first output port, a second output port, and a flow path defined in part by the input port and the second output port. The vacuum source is in fluid communication with the first output port and operative to apply a vacuum to the flow path. The actuator is operative to facilitate movement of the solution along the flow path.Type: ApplicationFiled: May 15, 2019Publication date: November 19, 2020Applicant: GE Precision Healthcare LLCInventors: ARNAUD COMMENT, RUI CHEN, ALBERT CHEN, GALEN REED, JONATHAN MURRAY
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Publication number: 20200355773Abstract: A system for hyperpolarizing a substance is provided. The system includes a cryostat and a polarizer. The cryostat is operative to generate radicals within the substance by exposing the substance to electromagnetic radiation. The polarizer is operative to hyperpolarize the substance via the radicals. Once the substance is polarized, the radicals contained within the substance are quenched by adjusting a temperature of the substance to greater than or equal to a melting point of the substance. In embodiments, the polarizer may then rapidly freeze the substance.Type: ApplicationFiled: May 7, 2019Publication date: November 12, 2020Applicant: GE Precision Healthcare LLCInventors: ARNAUD COMMENT, ALBERT CHEN
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Patent number: 10520561Abstract: A system for hyperpolarizing a substance is provided. The system includes a cryostat, a polarizer, and a shuttle. The cryostat is operative to generate radicals within the substance by exposing the substance to electromagnetic radiation. The polarizer is operative to hyperpolarize the substance via the radicals, and to quench the radicals within the substance by adjusting a temperature of the substance after the substance has been hyperpolarized. The shuttle is operative to transport the substance while maintaining hyperpolarization of the substance.Type: GrantFiled: September 27, 2017Date of Patent: December 31, 2019Assignees: GENERAL ELECTRIC COMPANY, MEMORIAL SLOAN KETTERING CANCER CENTERInventors: Arnaud Comment, Albert P. Chen, Kayvan Rahimi Keshari
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Patent number: 10481222Abstract: A cooling system is provided. The cooling system is associated with a dynamic nuclear polarization system and configured to cool a sample to a temperature suitable for dynamic nuclear polarization to be carried out on the sample while the sample is in the cooling system. The cooling system includes a cryogenic chamber that includes a cryogenic fluid. The cooling system also includes a removable sample sleeve insertable within a portion of the cryogenic chamber. The removable sample sleeve is configured to define a sample path for the sample within the cryogenic chamber that is isolated from other parts of the cooling system.Type: GrantFiled: July 24, 2017Date of Patent: November 19, 2019Assignee: General Electric CompanyInventors: Ernst Wolfgang Stautner, Jan Henrik Ardenkjaer-Larsen, Patrick L. Padgett, Jonathan Alan Murray, Rui Chen, James Richard Trigger, Arnaud Comment, Albert Po-Fu Chen
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Publication number: 20190094316Abstract: A system for hyperpolarizing a substance is provided. The system includes a cryostat, a polarizer, and a shuttle. The cryostat is operative to generate radicals within the substance by exposing the substance to electromagnetic radiation. The polarizer is operative to hyperpolarize the substance via the radicals, and to quench the radicals within the substance by adjusting a temperature of the substance after the substance has been hyperpolarized. The shuttle is operative to transport the substance while maintaining hyperpolarization of the substance.Type: ApplicationFiled: September 27, 2017Publication date: March 28, 2019Applicants: GENERAL ELECTRIC COMPANY, MEMORIAL SLOAN KETTERING CANCER CENTERInventors: ARNAUD COMMENT, ALBERT P. CHEN, KAYVAN RAHIMI KESHARI
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Publication number: 20190025387Abstract: A cooling system is provided. The cooling system is associated with a dynamic nuclear polarization system and configured to cool a sample to a temperature suitable for dynamic nuclear polarization to be carried out on the sample while the sample is in the cooling system. The cooling system includes a cryogenic chamber that includes a cryogenic fluid. The cooling system also includes a removable sample sleeve insertable within a portion of the cryogenic chamber. The removable sample sleeve is configured to define a sample path for the sample within the cryogenic chamber that is isolated from other parts of the cooling system.Type: ApplicationFiled: July 24, 2017Publication date: January 24, 2019Inventors: Ernst Wolfang Stautner, Jan Henrik Ardenkjaer-Larsen, Patrick L. Padgett, Jonathan Alan Murray, Rui Chen, James Richard Trigger, Arnaud Comment, Albert Po-Fu Chen
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Patent number: 10114088Abstract: A method for the preparation of a sample comprising highly polarized nuclear spins is proposed, comprising at least the following steps: a) provision of molecules with 1,2-dione structural units and/or molecules with 2,5-diene-1,4-dione structural units in the solid state; b) generation of radicals from these molecules by photo induced electron transfer by a first electromagnetic irradiation in the visible or ultraviolet frequency range in the solid state; c) dynamic nuclear polarization in the presence of a magnetic field in the solid state by applying a second electromagnetic irradiation with a frequency adapted to transfer spin polarization from the electrons to the nuclear spins leading to a highly polarized state thereof. Furthermore uses of correspondingly prepared samples for NMR, MRS and MRI experiments are proposed.Type: GrantFiled: March 14, 2013Date of Patent: October 30, 2018Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Tim Rolf Eichhorn, Christophe Roussel, Arnaud Comment
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Publication number: 20160033590Abstract: A method for the preparation of a sample comprising highly polarized nuclear spins is proposed, comprising at least the following steps: a) provision of molecules with 1,2-dione structural units and/or molecules with 2,5-diene-1,4-dione structural units in the solid state; b) generation of radicals from these molecules by photo induced electron transfer by a first electromagnetic irradiation in the visible or ultraviolet frequency range in the solid state; c) dynamic nuclear polarization in the presence of a magnetic field in the solid state by applying a second electromagnetic irradiation with a frequency adapted to transfer spin polarization from the electrons to the nuclear spins leading to a highly polarized state thereof. Furthermore uses of correspondingly prepared samples for NMR, MRS and MRI experiments are proposed.Type: ApplicationFiled: March 14, 2013Publication date: February 4, 2016Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Tim Rolf EICHHORN, Christophe ROUSSEL, Arnaud COMMENT
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Patent number: 8456162Abstract: A method for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements, includes creation of enhanced polarization of nuclei of a first kind within a sample in a magnetic field at cryogenic temperatures and transfer of the polarized sample to room temperature. The enhanced polarization of nuclei of the first kind is thereby transformed into long-lived states (LLS) of nuclei of a second kind and these LLS are sustained. The LLS is at least partially converted into observable magnetization and an NMR or MRI measurement is carried out. The method allows one to extend the time needed between hyperpolarized magnetization and NMR detection.Type: GrantFiled: April 30, 2010Date of Patent: June 4, 2013Assignees: Bruker BioSpin AG, Ecole Polytechnique Fédérale de Lausanne (EPFL)Inventors: Paul Romeo Vasos, Arnaud Comment, Riddhiman Sarkar, Sami Antoine Jannin, Geoffrey Bodenhausen
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Patent number: 8034027Abstract: An infusion pump comprising a substance and pushing fluid inlet, a substance outlet, a central chamber communicating with said inlet and said outlet, and injecting means for injecting a substance into a biological object, wherein the infusion pump further includes a pushing fluid outlet in communication with the central chamber in such a way as to allow a pushing fluid to exhaust the pump. The outlet of the infusion pump is advantageously connected to the proximal end of a catheter, the distal end being inserted into the biological object. A sensor, e.g., an optical device, is preferably placed at the outlet of the infusion pump and checks that the outlet is free of gas. The infusion pump is preferably remotely controlled so that it can be placed in limited access locations. It is also preferably computer controlled.Type: GrantFiled: May 12, 2008Date of Patent: October 11, 2011Assignee: Ecole Polytechnique Federale De Lausanne (EPPL)Inventors: Arnaud Comment, Jacques Van Der Klink
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Publication number: 20110001475Abstract: A method for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements, includes creation of enhanced polarization of nuclei of a first kind within a sample in a magnetic field at cryogenic temperatures and transfer of the polarised sample to room temperature. The enhanced polarization of nuclei of the first kind is thereby transformed into long-lived states (LLS) of nuclei of a second kind and these LLS are sustained. The LLS is at least partially converted into observable magnetisation and an NMR or MRI measurement is carried out. The method allows one to extend the time needed between hyperpolarised magnetisation and NMR detection.Type: ApplicationFiled: April 30, 2010Publication date: January 6, 2011Applicants: Bruker BioSpin AG, Ecole Polytechnique Fédérale de Lausanne (EPFL)Inventors: Paul Romeo Vasos, Arnaud Comment, Riddhiman Sarkar, Sami Antoine Jannin, Geoffrey Bodenhausen
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Publication number: 20080287875Abstract: An infusion pump comprising a substance and pushing fluid inlet, a substance outlet, a central chamber communicating with said inlet and said outlet, and injecting means for injecting a substance into a biological object, wherein the infusion pump further includes a pushing fluid outlet in communication with the central chamber in such a way as to allow a pushing fluid to exhaust the pump. The outlet of the infusion pump is advantageously connected to the proximal end of a catheter, the distal end being inserted into the biological object. A sensor, e.g., an optical device, is preferably placed at the outlet of the infusion pump and checks that the outlet is free of gas. The infusion pump is preferably remotely controlled so that it can be placed in limited access locations. It is also preferably computer controlled.Type: ApplicationFiled: May 12, 2008Publication date: November 20, 2008Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Arnaud COMMENT, Jacques VAN DER KLINK