Abstract: A dissolution system includes a dissolution line and a bypass line. The dissolution line fluidly couples a biocontainer, a pump, a cartridge, an upstream filter, and a downstream filter in a circulation loop. The bypass line is in fluid communication with the dissolution line at an upstream junction and a downstream junction such that the bypass line is in parallel relationship with the cartridge. A flow control system is configured to control the flow of fluid through the cartridge such that the flow of fluid through at least one of the dissolution line and the bypass line is selectively controlled based upon a pressure in the dissolution line downstream of the cartridge between the cartridge and the biocontainer.