Abstract: A device for performing electrical measurements, for example electrical activity across a layer of epithelial cells are disclosed. The device comprises a cassette having first and second surfaces, the cassette configured to engage with a microtiter plate and comprising a plurality of electrodes extending from the first surface in the direction of the microtiter plate when the cassette is engaged with the microtiter plate; and a housing detachably attached to the second surface of the cassette, comprising one or more heat management elements, and a processor comprising a data acquisition module electrically connected to the electrodes and a data processing module. A method of in vitro method for measuring electrical properties of cells cultured in a microfluidic device, for example using the device is also described.