Patents by Inventor Arne E. Brandstrom
Arne E. Brandstrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5441968Abstract: The novel compounds of the formulas I and I' ##STR1## wherein F is in 5 or 6 position and ##STR2## wherein in both formulas R is the group --CH.sub.2 OCOOR.sup.1, wherein R.sup.1 is a straight or branched alkyl containing 1-6 carbon atoms or benzyl, or R.sup.1 is the group ##STR3## wherein n is 1-6 and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.Type: GrantFiled: October 8, 1993Date of Patent: August 15, 1995Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Gunnel E. Sunden
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Patent number: 5386032Abstract: The present invention relates to an improved method for the synthesis of omeprazole, comprising the steps of reacting 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-1H-benzimida zole with m-chloroperoxybenzoic acid in a methylene chloride solution at a substantially constant pH of about 8.0 to 8.6; extracting the reaction mixture with aqueous NaOH; separating the aqueous phase from the organic phase; and adding an alkyl formate to the aqueous phase, resulting in crystallization of omeprazole.Type: GrantFiled: May 25, 1993Date of Patent: January 31, 1995Assignee: Aktiebolaget AstraInventor: Arne E. Brandstrom
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Patent number: 5049674Abstract: The novel compounds of the formulas I and I' ##STR1## wherein F is in 5 or 6 position and ##STR2## wherein in both formulas R is the group --CH.sub.2 OCOOR.sup.1, wherein R.sup.1 is a straight or branched alkyl containing 1-6 carbon atoms or benzyl, or R.sup.1 is the group ##STR3## --(CH.sub.2).sub.n COOH or --(CH.sub.2).sub.n SO.sub.3 H wherein n is 1-6 and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.Type: GrantFiled: December 20, 1989Date of Patent: September 17, 1991Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Gunnel E. Sunden
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Patent number: 5039808Abstract: The novel compound 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimid azole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing the compound as active ingredient, and the use of the compound in medicine.Type: GrantFiled: December 20, 1990Date of Patent: August 13, 1991Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Gunnel E. Sunden
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Patent number: 5025024Abstract: The novel compound 4-fluoro-2-[[(4-methoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compound in medicine.Type: GrantFiled: December 20, 1989Date of Patent: June 18, 1991Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Gunnel E. Sunden
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Patent number: 5019584Abstract: 5-Chloro-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as an intermediate, pharmaceutical compositions containing such compound as active ingredient, and the use of the compound in medicine.Type: GrantFiled: December 20, 1989Date of Patent: May 28, 1991Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Carl I. Starke, Gunnel E. Sunden
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Patent number: 5008278Abstract: The novel compound 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridinyl) methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing the compound as active ingredient, and the use of the compound in medicine.Type: GrantFiled: December 20, 1989Date of Patent: April 16, 1991Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Gunnel E. Sunden
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Patent number: 4965269Abstract: The novel compounds of the formula I ##STR1## wherein Cl is in 5 or 6 position and whereby R is the group --CH.sub.2 OCOOR.sup.1, wherein R.sup.1 is a straight or branched alkyl containing 1-6 carbon atoms or benzyl,or R.sup.1 is the group --(CH.sub.2).sub.n ##STR2## --(CH.sub.2).sub.n COOH or --(CH.sub.2).sub.n SO.sub.3 H wherein n is 1-6 and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.Type: GrantFiled: December 20, 1989Date of Patent: October 23, 1990Assignee: AB HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Carl I. Starke, Gunnel E. Sunden
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Patent number: 4738974Abstract: Novel salts of omeprazole with Li.sup.+, Na.sup.+, K.sup.+, Mg.sup.2+, Ca.sup.2+, Ti.sup.4+, N.sup.+ (R.sup.1).sub.4 or ##STR1## as cation; processes for their preparation thereof, pharmaceutical compositions containing such salts and their use in medicine.Type: GrantFiled: April 21, 1986Date of Patent: April 19, 1988Assignee: Aktiebolaget HassleInventor: Arne E. Brandstrom
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Patent number: 4725691Abstract: Novel compounds of the formula IIIa ##STR1## wherein R.sup.1a, R.sup.2a, R.sup.3a and R.sup.4a are the same or different and are hydrogen, an alkyl, alkoxy optionally completely or predominantly substituted by fluorine or chlorine, halogen, --CN, --CF.sub.3, --NO.sub.2, --COR, --COOR, aryl, aryloxy or arylalkoxy group, or adjacent groups R.sup.1a, R.sup.2a, R.sup.3a and R.sup.4a together with the adjacent carbon atoms in the benzimidazole ring form a 5-, 6- or 7-membered monocyclic ring or a 9-, 10- or 11-membered bicyclic ring, which rings may be saturated or unsaturated and may contain 0-3 heteroatoms selected from N and O and which rings may be optionally substituted with 1-4 substitutents selected from alkyl groups with 1-3 carbon atoms, halogen preferably F or Cl, alkylene radicals containing 4-5 carbon atoms giving spiro compounds, or two or four of these substituents together form one or two oxy groups ##STR2## whereby if R.sup.1a, R.sup.2a, R.sup.3a and R.sup.Type: GrantFiled: September 30, 1986Date of Patent: February 16, 1988Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Bjorn Wallmark
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Patent number: 4689331Abstract: Novel compounds of the formula I ##STR1## and its salts; process for the preparation thereof, pharmaceutical compositions containing such compounds and their use in medicine to affect gastric acid secretion and provide gastrointestinal cytoprotection.Type: GrantFiled: October 18, 1985Date of Patent: August 25, 1987Assignee: Aktiebolaget HassleInventors: Kjell F. Ankner, Arne E. Brandstrom, Per L. Lindberg, Mats P. Nordberg, Bjorn M. G. Wallmark
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Patent number: 4636499Abstract: Novel compounds of the formula IIIa ##STR1## wherein R.sup.1a, R.sup.2a, R.sup.3a and R.sup.4a are the same or different and are hydrogen, an alkyl, alkoxy optionally completely or predominantly substituted by fluorine or chlorine, halogen, --CN, --CF.sub.3, --NO.sub.2, --COR, --COOR, aryl, aryloxy or arylalkoxy group, or adjacent groups R.sup.1a, R.sup.2a, R.sup.3a and R.sup.4a together with the adjacent carbon atoms in the benzimidazole ring form a 5-, 6- or 7-membered monocyclic ring or a 9-, 10- or 11-membered bicyclic ring, which rings may be saturated or unsaturated and may contain 0-3 heteroatoms selected from N and O and which rings may be optionally substituted with 1-4 substitutents selected from alkyl groups with 1-3 carbon atoms, halogen perferably F or Cl, alkylene radicals containing 4-5 carbon atoms giving spiro compounds, or two or four of these substituents together form one or two oxy groups ##STR2## whereby if R.sup.1a, R.sup.2a, R.sup.3a and R.sup.Type: GrantFiled: May 30, 1985Date of Patent: January 13, 1987Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Per L. Lindberg, Bjorn Wallmark
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Patent number: 4620008Abstract: Novel compounds of the formula ##STR1## wherein R is H or CH.sub.3, a process for their preparation, and their use as intermediates in the preparation of pharmaceutically useful compounds, e.g. substituted benzimidazoles containing a pyridine radical, i.a. omeprazole.Type: GrantFiled: February 1, 1985Date of Patent: October 28, 1986Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Bo R. Lamm
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Patent number: 4544750Abstract: Novel compounds of the formula ##STR1## wherein R is H or CH.sub.3, a process for their preparation, and their use as intermediates in the preparation of pharmaceutically useful compounds, e.g. substituted benzimidazoles containing a pyridine radical, i.a. omeprazole.Type: GrantFiled: August 26, 1983Date of Patent: October 1, 1985Assignee: Aktiebolaget HassleInventors: Arne E. Brandstrom, Bo R. Lamm
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Patent number: 4145442Abstract: Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R.sup.1 is alkyl or hydroxyalkyl, R.sup.2 is alkoxyalkyl or alkylthioalkyl, and R.sup.3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed, as are methods for their preparation.Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.Type: GrantFiled: August 31, 1976Date of Patent: March 20, 1979Assignee: Aktiebolaget HassleInventors: Peder B. Berntsson, Arne E. Brandstrom, Enar I. Carlsson, Stig A. I. Carlsson, Lars Ek, Benny R. Samuelsson, Sven E. Sjostrand, Gert C. Strandlund, Bengt A. H. Ablad