Patents by Inventor Arne van der Gen

Arne van der Gen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing optically active cyanohydrin derivatives
    Patent number: 5493047
    Abstract: The invention relates to a method of preparing an optically active cyanohydrin carboxylic acid ester from an optically active cyanohydrin of opposite configuration, wherein said starting cyanohydrin is converted with a carboxylic acid in the presence of a dialkyl azodicarboxylate and a triarylphosphine.The invention also relates to a method of preparing an optically active cyanohydrin of opposite configuration by a subsequent solvolysis of the ester obtained under conservation of the configuration.
    Type: Grant
    Filed: December 6, 1993
    Date of Patent: February 20, 1996
    Assignee: Duphar International Research B.V.
    Inventors: Johannes Brussee, Arne Van Der Gen, Erwin G. J. C. Warmerdam, Chris G. Kruse
  • Method of preparing vicinal aminoalcohols
    Patent number: 5412119
    Abstract: The present invention is concerned with the preparation of N-substituted vicinal aminoalcohol derivatives from the corresponding hydroxyl-protected cyanohydrin derivatives by successive partial reduction, transimination using a primary amine, reduction of the resulting imine and optional removal of the hydroxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the starting cyanohydrin derivatives.The present invention is also concerned with certain new enantiomerically pure hydroxyl-protected vicinal aminoalcohols.
    Type: Grant
    Filed: February 1, 1993
    Date of Patent: May 2, 1995
    Assignee: Duphar International Research B.V.
    Inventors: Johannes Brussee, Arne van der Gen, Chris G. Kruse
  • Method of preparing optically active alcohols which consist substantially or entirely of one enantiomer
    Patent number: 5329023
    Abstract: The invention relates to a method of preparing optically active alcohols which consist substantially (at least 75% e.e.) or entirely of one enantiomer of formula 4 ##STR1## wherein R and A are as defined therein. The method comprises, which maintaining enantiomeric excess, converting an optically active cyanohydrin of formula 1 ##STR2## into optically active protected cyanohydrin of formula 2 ##STR3## converting the protected cyanohydrin of formula 2 into an optically active compound of formula 3 ##STR4## removing the protecting group B.
    Type: Grant
    Filed: June 15, 1992
    Date of Patent: July 12, 1994
    Assignee: Duphar International Research B.V.
    Inventors: Johannes Brussee, Arne Van Der Gen
  • Method for the preparation of erythro vicinal amino-alcohols
    Patent number: 5189219
    Abstract: The present invention is concerned with the preparation of erythro N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives by successive Grignard reaction, transimination using a primary amine, reduction of the resulting imine and removal of the hydroxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the cyanohydrin derivatives.
    Type: Grant
    Filed: December 19, 1991
    Date of Patent: February 23, 1993
    Assignee: Duphar International Research B.V.
    Inventors: Johannes Brussee, Arne van der Gen, Cornelis G. Kruse
  • Method for the preparation of erythro vicinyl amino-alcohols
    Patent number: RE35128
    Abstract: The present invention is concerned with the preparation of erythro N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives by successive Grignard reaction, transimination using a primary amine, reduction of the resulting imine and removal of the hydroxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the cyanohydrin derivatives.
    Type: Grant
    Filed: June 7, 1994
    Date of Patent: December 19, 1995
    Assignee: Duphar International Research B.V.
    Inventors: Johannes Brussee, Arne van der Gen, Cornelis G. Kruse