Abstract: In the case of a package (1) for single-dose films (2) containing active substances, comprising an upper packaging material element (3) and a lower packaging material element (4) which are connected together by a peripheral seal area or respectively sealing seam (5) such that a cavity (6) for holding the film (2) is formed, said cavity being enclosed on all sides, wherein the upper packaging material element (3) and the lower packaging material element (4) each have at least one cut (7, 8) in the region of the seal area or respectively, the sealing seam (5), said cuts being congruent, and at least one cut (7, 8) is crossed by a folding or bending line (10), the folding or bending line (10) is formed in a weakened manner.

Abstract: In the case of a package (1) for single-dose films (2) containing active substances, comprising an upper packaging material element (3) and a lower packaging material element (4) which are connected together by a peripheral seal area or respectively sealing seam (5) such that a cavity (6) for holding the film (2) is formed, said cavity being enclosed on all sides, wherein the upper packaging material element (3) and the lower packaging material element (4) each have at least one cut (7, 8) in the region of the seal area or respectively, the sealing seam (5), said cuts being congruent, and at least one cut (7, 8) is crossed by a folding or bending line (10), the folding or bending line (10) is formed in a weakened manner.

Abstract: The invention relates to a prosthesis comprising at least one artificial limb (6) of an extremity and a shank (2), connected to the artificial limb (6), comprising a proximal opening for accommodating an amputation stump. The aim of the invention is to reduce the weight of a prosthesis of the above kind and increase its wearing comfort. For this purpose, the shank (2) consists of a stable outer shank (3) constituting the connection to the artificial limb (6) and a flexible Inner shank (4). The outer shank (3) has a distal endpiece (6) and shell segments (7, 8) extending therefrom towards the proximal pats, forming a space (9) between them.

Abstract: The invention relates to nucleic acid molecules which encode fusion proteins which contain as components at least one effector module, a processing module and a targeting module. The nucleic acid molecules according to the invention preferably also encode a modulator module and/or an affinity module. The invention furthermore relates to vectors containing these nucleic acid molecules, hosts transformed with the vectors according to the invention, fusion proteins encoded by nucleic acids according to the invention or produced by the hosts according to the invention as well as to medicaments containing the polypeptides or vectors according to the invention. The invention thus also concerns corresponding processes, uses and kits.

Abstract: The invention relates to nucleic acid molecules which encode fusion proteins which contain as components at least one effector module, a processing module and a targeting module. The nucleic acid molecules according to the invention preferably also encode a modulator module and/or an affinity module. The invention furthermore relates to vectors containing these nucleic acid molecules, hosts transformed with the vectors according to the invention, fusion proteins encoded by nucleic acids according to the invention or produced by the hosts according to the invention as well as to medicaments containing the polypeptides or vectors according to the invention. These medicaments are particularly significant for the therapy of diseases associated with a pathological reproduction and/or increased activity of cell populations.

Abstract: The disclosure concerns a roll changing device for roll stands of a rolling mill or the like having a pair of working rolls and backing rolls assigned to each working roll in which the roll pairs, including their component bearing parts, can be moved as separate units into and out of the windows of the housings of the mill. A piston cylinder assembly provided for this purpose is arranged in front of the understructure for the support member of the lower backing roll.