Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: An electronic tuner generates a pulse train signal from an analog signal transduced from vibrations on a selected one of several strings of a musical instrument. The pulse train signal has a plurality of successive pulses, each of the pulses having a pulse width which may vary between successive pulses. Two of the pulses have a longest pulse width of all pulses in the pulse string are identified. The tuner then computes a current fundamental frequency on the selected string as a function of a ratio between a numerical count of the pulses occurring between these two pulses, the count including one of these pulses, and a sum of the pulse width of each of the pulses included in the count. The two of the pulses have a longest pulse width of all pulses in the pulse string. A difference signal is developed as a function of a difference between the current fundamental frequency and a known in-tune frequency associated with the selected string being tuned.

Abstract: A parity predict circuit for an M-level N'th power Galois arithmetic gate using binary logic elements and a method of the designing thereof is disclosed. The method involves an algorithm that the logic designer utilizes to visually analyze the output of the arithmetic gate using a heuristic technique to determine the procedure for intercoupling the outputs of the gate's 1 through m-1 levels of parity trees as inputs to the parity predict parity tree. This visual analysis obviates the laborious mathematical treatment of the arithmetic gate priorly utilized to design a parity predict network.