Patents by Inventor Arnold E. Hampel

Arnold E. Hampel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hairpin ribozymes
    Patent number: 6221661
    Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a “hairpin” portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 24, 2001
    Assignees: The of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development Corporation
    Inventors: Arnold E. Hampel, Richard H. Tritz, Margaret F. Hicks
  • HIV targeted hairpin ribozymes
    Patent number: 5869339
    Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 9, 1999
    Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development Corporation
    Inventors: Arnold E. Hampel, Richard H. Tritz, Margaret F. Hicks
  • HIV targeted hairpin ribozymes
    Patent number: 5866701
    Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: February 2, 1999
    Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development Corporation
    Inventors: Arnold E. Hampel, Richard H. Tritz
  • HIV targeted ribozymes
    Patent number: 5858785
    Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 12, 1999
    Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development Corporation
    Inventors: Arnold E. Hampel, Richard H. Tritz
  • Hairpin ribozymes
    Patent number: 5856188
    Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 5, 1999
    Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development Corporation
    Inventors: Arnold E. Hampel, Richard H. Tritz, Margaret F. Hicks
  • SArMV and sCYMVI hairpin ribozymes
    Patent number: 5646031
    Abstract: A method for the identification by modeling of synthetic catalytic RNAs and ribozymes thereof are disclosed including a hairpin portion and binding sites for cleaving an RNA substrate at a site which has a GUA sequence following the site of cleavage. Synthetic catalytic RNA has been modeled from negative strands of satellite RNA from the group consisting of chicory yellow mottle virus (sCYMVI) and arabis mosaic virus (sArMV).
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: July 8, 1997
    Assignee: Northern Illinois University
    Inventors: Mary Beth DeYoung, Andrew M. Siwkowski, Arnold E. Hampel
  • HIV targeted hairpin ribozymes
    Patent number: 5527895
    Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst omprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
    Type: Grant
    Filed: November 16, 1993
    Date of Patent: June 18, 1996
    Assignee: The Board of Regents for Northern Illinois University of DeKalb
    Inventors: Arnold E. Hampel, Richard H. Tritz