Patents by Inventor Arnold Fridland

Arnold Fridland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multidrug resistance associated proteins and uses thereof
    Patent number: 6759238
    Abstract: The present invention relates to multi-drug resistance, specifically to multi-drug resistant protein 4 (MRP4) and uses thereof. The present invention provides nucleic acid encoding MRP4, MRP4 protein, antibody reactive to MRP4 and discloses MRP4 as perhaps the first mammalian efflux pump described for nucleoside analogs. The present invention provides the first example of a role of MRP4 in drug resistance. Certain patients who develop drug resistance to anti-microbial therapy or anti-cancer therapy may develop cellular resistance mediated by MRP4. Accordingly, the present invention possesses both diagnostic and therapeutic utility as diagnostic kits, including drug assays and screens are contemplated, as well as pharmaceutical compositions and the corresponding methods of their respective use. For example, a diagnostic kit is disclosed that may be used in order to facilitate determination of patient susceptibility to MRP4 mediated drug resistance.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: July 6, 2004
    Assignee: St. Jude Children's Research Hospital
    Inventors: John Schuetz, Arnold Fridland
  • Bioassay for reverse transcriptase inhibitors
    Patent number: 5576177
    Abstract: The present invention relates generally to methods and kits for determining the bodily level of a reverse transcriptase inhibitor or, therapeutic compound or metabolite thereof used to treat retrovirus infection, particularly HIV 1 infection.
    Type: Grant
    Filed: March 9, 1994
    Date of Patent: November 19, 1996
    Assignee: St. Jude Children's Research Hospital
    Inventors: Arnold Fridland, Brian L. Robbins