Patents by Inventor Arnold Hans

Arnold Hans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antigen Discovery for T Cell Receptors Isolated from Patient Tumors Recognizing Wild-Type Antigens and Potent Peptide Mimotopes
    Publication number: 20200392201
    Abstract: Compositions and methods are provided for peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.
    Type: Application
    Filed: August 3, 2020
    Publication date: December 17, 2020
    Inventors: MARVIN GEE, MARK M. DAVIS, ARNOLD HAN, KENAN CHRISTOPHER GARCIA
  • Antigen Discovery for T Cell Receptors Isolated from Patient Tumors Recognizing Wild-Type Antigens and Potent Peptide Mimotopes
    Publication number: 20200010527
    Abstract: Compositions and methods are provided for peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.
    Type: Application
    Filed: March 21, 2018
    Publication date: January 9, 2020
    Inventors: Marvin Gee, Mark M. Davis, Arnold Han, Kenan Christopher Garcia
  • Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
    Patent number: 10202640
    Abstract: Methods and oligonucleotide reagents for analyzing individual T cells are disclosed. In particular, the present disclosure provides methods for analyzing individual T cells using high-throughput multiplex amplification and deep sequencing of nucleic acids encoding T cell receptors (TCRs) and various other T cell phenotypic markers. The present disclosure further provides methods of reconstituting TCRs from individual T cells for functional studies, ligand discovery, or screening therapeutics.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: February 12, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark M. Davis, Jacob Glanville, Arnold Han
  • METHODS FOR DIAGNOSIS OF CELIAC DISEASE
    Publication number: 20160091491
    Abstract: A diagnostic test for celiac disease is disclosed. In particular, the invention relates to a method of diagnosing celiac disease by detecting activated, gut-bound CD8+ alpha-beta T lymphocytes and gamma-delta T lymphocytes in the peripheral blood of a subject who has consumed gluten for one to three days. This diagnostic test has a number of advantages over current tests for celiac test, including that the test is noninvasive, relatively inexpensive, and requires voluntary gluten ingestion over a short period of time.
    Type: Application
    Filed: April 28, 2014
    Publication date: March 31, 2016
    Inventors: Mark M. Davis, Arnold Han, Evan W. Newell
  • SINGLE CELL ANALYSIS OF T CELLS USING HIGH-THROUGHPUT MULTIPLEX AMPLIFICATION AND DEEP SEQUENCING
    Publication number: 20150337369
    Abstract: Methods and oligonucleotide reagents for analyzing individual T cells are disclosed. In particular, the present disclosure provides methods for analyzing individual T cells using high-throughput multiplex amplification and deep sequencing of nucleic acids encoding T cell receptors (TCRs) and various other T cell phenotypic markers. The present disclosure further provides methods of reconstituting TCRs from individual T cells for functional studies, ligand discovery, or screening therapeutics.
    Type: Application
    Filed: April 30, 2015
    Publication date: November 26, 2015
    Inventors: Mark M. Davis, Jacob Glanville, Arnold Han
  • Method of making circuit boards with locally enhanced wiring density
    Patent number: 5582745
    Abstract: A printed circuit board and a method for making same is disclosed whereby a very high wiring density is provided in those regions of the printed circuit board in which external components (e.g., semiconductor chips) are to be attached directly. An automated registration routine permits very precise registration and positioning in said regions.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: December 10, 1996
    Assignee: International Business Machines Corporation
    Inventors: Arnold Hans, Peter Lueck, Guenther Mohr, Theis ZurNieden