Abstract: Thermal management systems and methods for manufacturing and using same are disclosed. Certain embodiments of the thermal management systems comprise configurations of corrugated, porous, or fibrous panels containing phase change materials within the interior of the panels. Liquid barrier layers are applied to the panels to at least keep the phase change materials from leaking out of the panels. The thermal management systems are passive systems which are able to maintain the temperature of pharmaceutical products placed within the systems within a predetermined temperature range over a predetermined period of time.