Patents by Inventor Arnold Hoffman
Arnold Hoffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7858659Abstract: The invention provides methods and compositions for treatment of tumors comprising administering to subject bearing a tumor an effective amount of at least one agent that decreases the [GSH]2/[GSSG] ratio in the malignant cells of said tumor, wherein said at least one agent is administered continuously to said patient for a period of time within the range of from about 15 to about 75 hours.Type: GrantFiled: July 18, 2003Date of Patent: December 28, 2010Inventors: Arnold Hoffman, Lee M. Spetner, Michael Burke
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Publication number: 20080287541Abstract: The present invention relates to a kit for the treatment of cancer comprising (a) a container for containing a first compound (i) or a precursor thereof, said first compound or precursor being a compound that oxidizes glutathione (GSH); (b) a container for containing a second compound (ii) or a precursor thereof, said second compound or precursor being a compound that forms an adduct or conjugate with GSH; (c) a container for containing a third compound (iii) or a precursor thereof, said third compound or precursor being a compound that inhibits the rate-limiting enzyme of GSH biosynthesis, gamma-glutamylcysteine synthetase (GCS); and (d) a container for containing a fourth compound (iv) or a precursor thereof, said fourth compound or precursor being a compound that inhibits the enzyme responsible for the conversion of GSSG to GSH, glutathione reductase (GR).Type: ApplicationFiled: May 9, 2005Publication date: November 20, 2008Applicant: Redoxia Israel Ltd.Inventors: Arnold Hoffman, Lee M. Spetner, Michael Burke
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Patent number: 6697170Abstract: A method for producing a half-tone image faithfully representing a continuous-tne original includes a step of forming in the image a pattern of substantially continuous, substantially parallel lines at a frequency of between about 100 and 400 lines per inch, such that the width of the lines at a given point in the image varies in relation to the optical density of at least one color component at a corresponding point in the continuous-tone original. The method may be used for color separations with each separation produced by scanning at a different angle. The method may be implemented using photomechanical or electronic scanning techniques.Type: GrantFiled: December 18, 2000Date of Patent: February 24, 2004Inventors: Yoel Netz, Arnold Hoffman
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Publication number: 20040018987Abstract: The invention provides methods and compositions for treatment of tumors comprising administering to subject bearing a tumor an effective amount of at least one agent that decreases the [GSH]2/[GSSG] ratio in the malignant cells of said tumor, wherein said at least one agent is administered continuously to said patient for a period of time within the range of from about 15 to about 75 hours.Type: ApplicationFiled: July 18, 2003Publication date: January 29, 2004Inventors: Arnold Hoffman, Lee M. Spetner, Michael Burke
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Publication number: 20020005961Abstract: A method for producing a half-tone image faithfully representing a continuous-tone original includes a step of forming in the image a pattern of substantially continuous, substantially parallel lines at a frequency of between about 100 and 400 lines per inch, such that the width of the lines at a given point in the image varies in relation to the optical density of at least one color component at a corresponding point in the continuous-tone original. The method may be used for color separations with each separation produced by scanning at a different angle. The method may be implemented using photomechanical or electronic scanning techniques.Type: ApplicationFiled: December 18, 2000Publication date: January 17, 2002Applicant: ARNOLD HOFFMANInventors: Yoel Netz, Arnold Hoffman
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Patent number: 6163382Abstract: A method for producing a half-tone image faithfully representing a continuous-tone original includes a step of forming in the image a pattern of substantially continuous, substantially parallel lines at a frequency of between about 100 and 400 lines per inch, such that the width of the lines at a given point in the image varies in relation to the optical density of at least one color component at a corresponding point in the continous-tone original. The method may be used for color separations with each separation produced by scanning at a different angle. The method may be implemented using photomechanical or electronic scanning techniques.Type: GrantFiled: February 20, 1998Date of Patent: December 19, 2000Inventors: Yoel Netz, Arnold Hoffman
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Patent number: 5793500Abstract: A method for producing a half-tone image faithfully representing a continuous-tone original includes a step of forming in the image a pattern of substantially continuous, substantially parallel lines at a frequency of between about 100 and 400 lines per inch, such that the width of the lines at a given point in the image varies in relation to the optical density of at least one color component at a corresponding point in the continuous-tone original. The method may be used for color separations with each separation produced by scanning at a different angle. The method may be implemented using photomechanical or electronic scanning techniques.Type: GrantFiled: January 21, 1994Date of Patent: August 11, 1998Inventors: Yoel Netz, Arnold Hoffman
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Patent number: 5283140Abstract: The invention provides a device for offset and similar printing from a continuous tone original to produce a halftone image on a photosensitive layer comprising means for screening the information via a first array of parallely extending lines of effective minimum optical density and a second array of parallely extending lines of effective maximum optical density, the arrays being interposed to form a composite array of substantially parallel, spaced-apart, alternating lines of effective maximum and minimum optical density, the lines delimiting therebetween zones of effective graduated optical density, the gradient inside each zone progressively varying from low optical density adjacent lines of the first array to high optical density adjacent lines of the second array, the spacing of lines of the first array being between about 100 and 400 lines per inch and wherein the resulting thickness of each reproduced line on a resulting developed photosensitive layer, generated by screening the information via the arType: GrantFiled: November 23, 1992Date of Patent: February 1, 1994Inventors: Yoel Netz, Arnold Hoffman
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Patent number: 5034767Abstract: A system for the development of exposed silver-halide films where the film moves emulsion-up on conveyor means, a viscous developer being applied to said film from a mechanism located above the moving film close to one end of the conveyor means, means being provided adjacent the other end to remove excess developer, means being provided for rinsing and fixing the developed film. The developer may be applied via a narrow slit at the bottom of a container, where the slit is essentially perpendicular to the direction of movement of the film. The uniformity of development layer may be attained by a roof-section above the moving film, the space being filled with developer.Type: GrantFiled: August 26, 1988Date of Patent: July 23, 1991Assignee: Hanetz International Inc.Inventors: Yoel Netz, Arnold Hoffman
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Patent number: 4598040Abstract: There is provided a developer for use in a one-step process for the development of exposed film resulting in an exposurewise pattern of silver particles which are large enough to be used as printing elements in ink-printing techniques, providing a wide range of densities in the developed film. The developer is based on a buffered system of a developing agent, a sulfinic acid salt of the type HO-R-SO.sub.2.M..times.H.sub.2 O where R is a hydrocarbyl group and M is a cation, and a formaldehyde source, with conventional adjuvants such as anti-fogging agents and the like. Instead of the sulfinic acid salt defined above there may be used any compound which upon dissociation in a aqueous medium results in the same active ionic species.Type: GrantFiled: September 12, 1983Date of Patent: July 1, 1986Inventors: Yoel Netz, Arnold Hoffman
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Patent number: 4373022Abstract: A radiation sensitive article formed with large and small grains of silver halide arranged for exposure to radiation and disposed so as to permit development of the large and small grains each under independent development conditions selected to provide image wise development thereof. A method for producing a high resolution high speed photographic image and apparatus for carrying out the method are also provided.Type: GrantFiled: December 27, 1979Date of Patent: February 8, 1983Assignee: Arnold HoffmanInventors: Arnold Hoffman, Shmuel Engelstein
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Patent number: 4193847Abstract: An electrode material is electrodeposited on a conductive substrate by contacting a first surface of the substrate with an electrolyte, establishing a vacuum at predetermined areas of the substrate opposite the surface containing the electrolyte, and causing a current flow in the areas of the conductive substrate where the vacuum has been established. Apparatus for carrying out the method is also disclosed.Type: GrantFiled: September 5, 1978Date of Patent: March 18, 1980Assignee: Polaroid CorporationInventors: Stanley M. Bloom, Arnold Hoffman, Kenneth S. Norland
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Patent number: 4185144Abstract: A cadmium patch laminar electrode, comprising a dispersion of particulate cadmium in a binder matrix on a conductive plastic substrate is prepared by contacting a zinc patch electrode comprising a dispersion of particulate zinc in a binder matrix on a conductive plastic substrate with an aqueous solution of a cadmium salt. The cadmium patch electrode can be used in a primary electrochemical cell such as that employing a manganese dioxide cathode and a cadmium chloride electrolyte.Type: GrantFiled: September 5, 1978Date of Patent: January 22, 1980Assignee: Polaroid CorporationInventors: Allan E. Ames, Stanley M. Bloom, Arnold Hoffman, Kenneth Norland
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Patent number: 4172184Abstract: A stable high capacity battery employs a lead foil having cadmium plated on at least one side thereof to a thickness of about 0.1 to 3 mils as the anode.Type: GrantFiled: September 5, 1978Date of Patent: October 23, 1979Assignee: Polaroid CorporationInventors: Stanley M. Bloom, Arnold Hoffman, Kenneth S. Norland
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Patent number: 4112205Abstract: A galvanic cell having a zinc anode which contains in the electrolyte as a corrosion inhibitor a chloride double salt containing mercuric ions and quaternary ions. The corrosion inhibitor may be represented by the formula:M Hg.sub.x Cl.sub.ywherein M is a quaternary ammonium cation, x is 1, 2 or 3, and y is 3 to 8.Type: GrantFiled: December 26, 1974Date of Patent: September 5, 1978Assignee: Polaroid CorporationInventors: John C. Charkoudian, Arnold Hoffman
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Patent number: 3953242Abstract: A galvanic cell, particularly a primary battery cell, having as the sole electrolyte a quaternary ammonium salt, particularly tetraalkyl ammonium chloride.Type: GrantFiled: October 26, 1973Date of Patent: April 27, 1976Assignee: Polaroid CorporationInventor: Arnold Hoffman
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Patent number: 3945849Abstract: A corrosion inhibitor for battery anodes, e.g., metals such as zinc, lead, and the like, in primary battery cells, comprises a quaternary ammonium salt, particularly, tetraalkyl ammonium chloride.Type: GrantFiled: June 26, 1970Date of Patent: March 23, 1976Assignee: Polaroid CorporationInventor: Arnold Hoffman