Patents by Inventor Arnold Hoffman

Arnold Hoffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7858659
    Abstract: The invention provides methods and compositions for treatment of tumors comprising administering to subject bearing a tumor an effective amount of at least one agent that decreases the [GSH]2/[GSSG] ratio in the malignant cells of said tumor, wherein said at least one agent is administered continuously to said patient for a period of time within the range of from about 15 to about 75 hours.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: December 28, 2010
    Inventors: Arnold Hoffman, Lee M. Spetner, Michael Burke
  • Publication number: 20080287541
    Abstract: The present invention relates to a kit for the treatment of cancer comprising (a) a container for containing a first compound (i) or a precursor thereof, said first compound or precursor being a compound that oxidizes glutathione (GSH); (b) a container for containing a second compound (ii) or a precursor thereof, said second compound or precursor being a compound that forms an adduct or conjugate with GSH; (c) a container for containing a third compound (iii) or a precursor thereof, said third compound or precursor being a compound that inhibits the rate-limiting enzyme of GSH biosynthesis, gamma-glutamylcysteine synthetase (GCS); and (d) a container for containing a fourth compound (iv) or a precursor thereof, said fourth compound or precursor being a compound that inhibits the enzyme responsible for the conversion of GSSG to GSH, glutathione reductase (GR).
    Type: Application
    Filed: May 9, 2005
    Publication date: November 20, 2008
    Applicant: Redoxia Israel Ltd.
    Inventors: Arnold Hoffman, Lee M. Spetner, Michael Burke
  • Patent number: 6697170
    Abstract: A method for producing a half-tone image faithfully representing a continuous-tne original includes a step of forming in the image a pattern of substantially continuous, substantially parallel lines at a frequency of between about 100 and 400 lines per inch, such that the width of the lines at a given point in the image varies in relation to the optical density of at least one color component at a corresponding point in the continuous-tone original. The method may be used for color separations with each separation produced by scanning at a different angle. The method may be implemented using photomechanical or electronic scanning techniques.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: February 24, 2004
    Inventors: Yoel Netz, Arnold Hoffman
  • Publication number: 20040018987
    Abstract: The invention provides methods and compositions for treatment of tumors comprising administering to subject bearing a tumor an effective amount of at least one agent that decreases the [GSH]2/[GSSG] ratio in the malignant cells of said tumor, wherein said at least one agent is administered continuously to said patient for a period of time within the range of from about 15 to about 75 hours.
    Type: Application
    Filed: July 18, 2003
    Publication date: January 29, 2004
    Inventors: Arnold Hoffman, Lee M. Spetner, Michael Burke
  • Publication number: 20020005961
    Abstract: A method for producing a half-tone image faithfully representing a continuous-tone original includes a step of forming in the image a pattern of substantially continuous, substantially parallel lines at a frequency of between about 100 and 400 lines per inch, such that the width of the lines at a given point in the image varies in relation to the optical density of at least one color component at a corresponding point in the continuous-tone original. The method may be used for color separations with each separation produced by scanning at a different angle. The method may be implemented using photomechanical or electronic scanning techniques.
    Type: Application
    Filed: December 18, 2000
    Publication date: January 17, 2002
    Applicant: ARNOLD HOFFMAN
    Inventors: Yoel Netz, Arnold Hoffman
  • Patent number: 6163382
    Abstract: A method for producing a half-tone image faithfully representing a continuous-tone original includes a step of forming in the image a pattern of substantially continuous, substantially parallel lines at a frequency of between about 100 and 400 lines per inch, such that the width of the lines at a given point in the image varies in relation to the optical density of at least one color component at a corresponding point in the continous-tone original. The method may be used for color separations with each separation produced by scanning at a different angle. The method may be implemented using photomechanical or electronic scanning techniques.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: December 19, 2000
    Inventors: Yoel Netz, Arnold Hoffman
  • Patent number: 5793500
    Abstract: A method for producing a half-tone image faithfully representing a continuous-tone original includes a step of forming in the image a pattern of substantially continuous, substantially parallel lines at a frequency of between about 100 and 400 lines per inch, such that the width of the lines at a given point in the image varies in relation to the optical density of at least one color component at a corresponding point in the continuous-tone original. The method may be used for color separations with each separation produced by scanning at a different angle. The method may be implemented using photomechanical or electronic scanning techniques.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: August 11, 1998
    Inventors: Yoel Netz, Arnold Hoffman
  • Patent number: 5283140
    Abstract: The invention provides a device for offset and similar printing from a continuous tone original to produce a halftone image on a photosensitive layer comprising means for screening the information via a first array of parallely extending lines of effective minimum optical density and a second array of parallely extending lines of effective maximum optical density, the arrays being interposed to form a composite array of substantially parallel, spaced-apart, alternating lines of effective maximum and minimum optical density, the lines delimiting therebetween zones of effective graduated optical density, the gradient inside each zone progressively varying from low optical density adjacent lines of the first array to high optical density adjacent lines of the second array, the spacing of lines of the first array being between about 100 and 400 lines per inch and wherein the resulting thickness of each reproduced line on a resulting developed photosensitive layer, generated by screening the information via the ar
    Type: Grant
    Filed: November 23, 1992
    Date of Patent: February 1, 1994
    Inventors: Yoel Netz, Arnold Hoffman
  • Patent number: 5034767
    Abstract: A system for the development of exposed silver-halide films where the film moves emulsion-up on conveyor means, a viscous developer being applied to said film from a mechanism located above the moving film close to one end of the conveyor means, means being provided adjacent the other end to remove excess developer, means being provided for rinsing and fixing the developed film. The developer may be applied via a narrow slit at the bottom of a container, where the slit is essentially perpendicular to the direction of movement of the film. The uniformity of development layer may be attained by a roof-section above the moving film, the space being filled with developer.
    Type: Grant
    Filed: August 26, 1988
    Date of Patent: July 23, 1991
    Assignee: Hanetz International Inc.
    Inventors: Yoel Netz, Arnold Hoffman
  • Patent number: 4598040
    Abstract: There is provided a developer for use in a one-step process for the development of exposed film resulting in an exposurewise pattern of silver particles which are large enough to be used as printing elements in ink-printing techniques, providing a wide range of densities in the developed film. The developer is based on a buffered system of a developing agent, a sulfinic acid salt of the type HO-R-SO.sub.2.M..times.H.sub.2 O where R is a hydrocarbyl group and M is a cation, and a formaldehyde source, with conventional adjuvants such as anti-fogging agents and the like. Instead of the sulfinic acid salt defined above there may be used any compound which upon dissociation in a aqueous medium results in the same active ionic species.
    Type: Grant
    Filed: September 12, 1983
    Date of Patent: July 1, 1986
    Inventors: Yoel Netz, Arnold Hoffman
  • Patent number: 4373022
    Abstract: A radiation sensitive article formed with large and small grains of silver halide arranged for exposure to radiation and disposed so as to permit development of the large and small grains each under independent development conditions selected to provide image wise development thereof. A method for producing a high resolution high speed photographic image and apparatus for carrying out the method are also provided.
    Type: Grant
    Filed: December 27, 1979
    Date of Patent: February 8, 1983
    Assignee: Arnold Hoffman
    Inventors: Arnold Hoffman, Shmuel Engelstein
  • Patent number: 4193847
    Abstract: An electrode material is electrodeposited on a conductive substrate by contacting a first surface of the substrate with an electrolyte, establishing a vacuum at predetermined areas of the substrate opposite the surface containing the electrolyte, and causing a current flow in the areas of the conductive substrate where the vacuum has been established. Apparatus for carrying out the method is also disclosed.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: March 18, 1980
    Assignee: Polaroid Corporation
    Inventors: Stanley M. Bloom, Arnold Hoffman, Kenneth S. Norland
  • Patent number: 4185144
    Abstract: A cadmium patch laminar electrode, comprising a dispersion of particulate cadmium in a binder matrix on a conductive plastic substrate is prepared by contacting a zinc patch electrode comprising a dispersion of particulate zinc in a binder matrix on a conductive plastic substrate with an aqueous solution of a cadmium salt. The cadmium patch electrode can be used in a primary electrochemical cell such as that employing a manganese dioxide cathode and a cadmium chloride electrolyte.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: January 22, 1980
    Assignee: Polaroid Corporation
    Inventors: Allan E. Ames, Stanley M. Bloom, Arnold Hoffman, Kenneth Norland
  • Patent number: 4172184
    Abstract: A stable high capacity battery employs a lead foil having cadmium plated on at least one side thereof to a thickness of about 0.1 to 3 mils as the anode.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: October 23, 1979
    Assignee: Polaroid Corporation
    Inventors: Stanley M. Bloom, Arnold Hoffman, Kenneth S. Norland
  • Patent number: 4112205
    Abstract: A galvanic cell having a zinc anode which contains in the electrolyte as a corrosion inhibitor a chloride double salt containing mercuric ions and quaternary ions. The corrosion inhibitor may be represented by the formula:M Hg.sub.x Cl.sub.ywherein M is a quaternary ammonium cation, x is 1, 2 or 3, and y is 3 to 8.
    Type: Grant
    Filed: December 26, 1974
    Date of Patent: September 5, 1978
    Assignee: Polaroid Corporation
    Inventors: John C. Charkoudian, Arnold Hoffman
  • Patent number: 3953242
    Abstract: A galvanic cell, particularly a primary battery cell, having as the sole electrolyte a quaternary ammonium salt, particularly tetraalkyl ammonium chloride.
    Type: Grant
    Filed: October 26, 1973
    Date of Patent: April 27, 1976
    Assignee: Polaroid Corporation
    Inventor: Arnold Hoffman
  • Patent number: 3945849
    Abstract: A corrosion inhibitor for battery anodes, e.g., metals such as zinc, lead, and the like, in primary battery cells, comprises a quaternary ammonium salt, particularly, tetraalkyl ammonium chloride.
    Type: Grant
    Filed: June 26, 1970
    Date of Patent: March 23, 1976
    Assignee: Polaroid Corporation
    Inventor: Arnold Hoffman