Abstract: Psychosis protecting (PP) nucleic acids and encoded PP peptides and related proteins, and antibodies, anti-idiotype antibodies, and fragments thereto, for treatment, diagnosis and/or research related to the protection from psychosis such as schizophrenia or related disorders, or symptoms thereof, and expression products, compositions and methods therefor, including treatment of schizophrenia and related disorders, as well as transgenic non-human mammals epxressing PP peptide or related protein encoding nucleic acids.

Abstract: Modification of the DNA encoding the enzyme tyrosine hydroxylase (TH) resulting in amino acid substitution in one of the first fifty five N-terminal residues, in particular replacing Ser-40 with Tyr or Leu, produced TH variants having substantially increased enzymatic activity upon transfection of suitable host cells. Cells transfected with the variant TH having enhanced enzymatic activity are useful for treating neurological or psychiatric disorders associated with deficient TH or dopamine, in particular Parkinson's disease, by grafting such cells into the brain.

Abstract: Modification of the DNA encoding the enzyme tyrosine hydroxylase (TH) resulting in amino acid substitution in one of the first fifty five N-terminal residues, in particular replacing Ser-40 with Tyr or Leu, produced TH variants having substantially increased enzymatic activity upon transfection of suitable host cells. Cells transfected with the variant TH having enhanced enzymatic activity are useful for treating neurological or psychiatric disorders associated with deficient TH or dopamine, in particular Parkinson's disease, by grafting such cells into the brain.