Abstract: Provided herein are methods of treating a neoplastic disease in a subject. In exemplary embodiments, the method comprises administering to the subject an aqueous solution comprising an anti-EGFRvIII agent using an administration system, wherein one or more of the components of the administration system, or parts thereof, which contact the aqueous solution substantially lack a polyvinyl chloride (PVC) and/or air. In exemplary aspects, the administration system is an infusion system comprising an infusion line, wherein at least part of the infusion line substantially lacks PVC. In exemplary aspects, the administration system comprises a container for containing the aqueous solution wherein less than about 5% of the volume of the container is air, when the container comprises the aqueous solution. Related kits are further provided herein.

Abstract: An approach for determining material compatibility for components of a drug delivery system is provided that includes using surface zeta-potential analytical method to evaluate surface interactions between a desired molecule and at least one material present within a given IV-bag system.

Abstract: The present disclosure provides solid protein formulations that are stable over a variety of temperatures for extended time periods. The present disclosure also provides methods of making and using these formulations.