Abstract: In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. The mutant toxin may include a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to methods and compositions for use in culturing Clostridium difficile and in producing C. difficile toxins.

Abstract: A virtual router network (VRN) for performing real-time flow measurements (RTFM) is provided. The VRN effectively reduces the number of traffic metering points required thereby simplifying the aggregation and exportation of flow records to a collector. The collector may be service manager in a network management system. The metering points, in a preferred embodiment, are at virtual interfaces (VI) which are edge nodes in VRN. One of the virtual interfaces is selected as a master virtual interface and act as a collector and distributor of flow related information. In one aspect of the invention the VRN is used to provide, non-invasively, per-flow delay monitoring in a communication system.

Abstract: A method and apparatus for assessing a communications' network adherence to Service Level Agreements (SLAs) is presented. The apparatus includes a arrival curve parameter derivation and arrival curve parameter reporting means. A arrival curve parameter generator may be implemented either in hardware for a predefined response in fitting arrival curves to cumulative content arrival variations, or in software for flexibility in the content traffic considered for assessment. The arrival curve generator may be associated with a physical port, a line card, or a network node. Arrival curve parameters defining arrival curves are employed by a Network Management System (NMS) in conjunction with communications network node and communications network service curves in performing SLA conformance assessments.

Abstract: In a multi-service network, layer 2 traffic such as IP traffic according to the invention is carried over ATM SVCs or SPVCs. Methods of setting up such connections using the PNNI protocol are also discussed. Using enhancements to the standard ATM SPVC/SVC signaling messages, layer 3 IP routing processes on multi-services switches on opposite ends of the network allow traffic to flow transparently through an underlying layer 2 virtual connection. This provides a simple and efficient way to transport IP packets across an ATM network.

Abstract: A virtual router network (VRN) for performing real-time flow measurements (RTFM) is provided. The VRN effectively reduces the number of traffic metering points required thereby simplifying the aggregation and exportation of flow records to a collector. The collector may be service manager in a network management system. The metering points, in a preferred embodiment, are at virtual interfaces (VI) which are edge nodes in VRN. One of the virtual interfaces is selected as a master virtual interface and act as a collector and distributor of flow related information. In one aspect of the invention the VRN is used to provide, non-invasively, per-flow delay monitoring in a communication system.

Abstract: A methods of implementing event based distributed multicast flow accounting are presented. Multicast-enabled routers request, and aggregate traffic flow measurement information from downstream multicast-enabled routers participating in dependent multicast sub-trees. Records are kept by the multicast-enabled router regarding changes to the underlying multicast tree topology. The aggregate traffic flow measurements and topology information are reported to multicast-enabled routers upstream. Advantages are derived from the ability to accurately compute multicast content transport costs within a communications service provider's network.

Abstract: A method and apparatus for assessing a communications' network adherence to Service Level Agreements (SLAs) is presented. The apparatus includes a arrival curve parameter derivation and arrival curve parameter reporting means. A arrival curve parameter generator may be implemented either in hardware for a predefined response in fitting arrival curves to cumulative content arrival variations, or in software for flexibility in the content traffic considered for assessment. The arrival curve generator may be associated with a physical port, a line card, or a network node. Arrival curve parameters defining arrival curves are employed by a Network Management System (NMS) in conjunction with communications network node and communications network service curves in performing SLA conformance assessments.

Abstract: A method and system for displaying a node of a communication network on a network management map. The geographical location of the node is determined by a positioning device such as GPS (or equivalent) device and stored in the home information of the node. The node is displayed in a position on the network management map in accordance with the geographical location. The GPS device may be located in the node or merely used to determine the longitude and latitude positions of the node which are then stored in the longitude and latitude fields of the node.

Abstract: A communication network having a network management system with a backup server adapted to create backup schedule for new nodes or nodes leaving the system. The new nodes are added when the network manager informs the backup server of the new node or the removal of a node from the system and requests that a backup schedule be created therefor. The backup schedule created for the new node is based on current backup policy.

Abstract: In a multi-service network, layer 2 traffic such as IP traffic according to the invention is carried over ATM SVCs or SPVCs. Methods of setting up such connections using the PNNI protocol are also discussed. Using enhancements to the standard ATM SPVC/SVC signaling messages, layer 3 IP routing processes on multi-services switches on opposite ends of the network allow traffic to flow transparently through an underlying layer 2 virtual connection. This provides a simple and efficient way to transport IP packets across an ATM network.